Genetics Of Asthma Research Paper

Cardiff scientists have recently found a link to the airway inflammation found in asthma patients. This inflammation

The ultimate goal of the workshop was to provide recommendations to the Institiute to fill in the gaps of the knowledge of lung disease genetics by applying different approaches.The workshop covered

About 10% of American children have asthma (Thakur et al., 2013). It is vital to understand what determinants cause childhood asthma to understand even with a low percentage, why it is still present. According to Williams et al., asthma is a health outcome which is a major impact on American youth (Williams et al., 2009). This health outcome not only impacts them throughout the years of being a child, but it has the potential of creating more serious health problems in the future. And without knowing what the causes are, it increases the rate asthma among children and prevents treatments from being implemented. It needs to be addressed by using results from prior studies in order to show how much of a problem childhood asthma is but also in finding and understanding the other underlying

I. Introduction: Looking at Asthma and breaking it down to fully understand the chronic disease.

However on the other hand whether genetics plays an important role in the development of asthma has been strongly accepted as numerous family and twin studies have been made. “Genome-wide linkage studies and case-control studies have identified 18 genomic regions and more than 100 genes associated with allergy and asthma in 11 different populations” (Subbarao, Mandhane, and Sears

Asthma is a chronic inflammatory lung disease that affects approximately 22 million people in the United States. Six million of those people are children, making it the most common chronic disease of children (“What is Asthma” and National 1). Asthma may be associated with morbidity, mortality, and diminished quality of life. Asthma is considered a long-term disease because there is currently no cure (Young). Further defining this disorder will be achieved by explaining the disease and symptoms, addressing how it is acquired, ways physicians diagnose it, and elaborating on treatments.

The good thing about asthma is that there are a lot of medications available to help treat asthma sufferers with acute onset of symptoms as well as help with the long term prognosis of patients. Asthma medications are classified into two groups, Controller and quick-relief. Controller medications are designed to help prevent asthma attacks. Their purpose is to try and reduce the chronic inflammation thus making the body less likely to react to triggers. Some of these include long-acting beta-agonists, Leukotriene modifiers, Mast cell stabilizers, Theophylline, and immunomodulators. Long-acting beta agonists are bronchodilators that assist in opening up your airways. These are normally aerolized medications. The bronchodilator causes the muscles

5) Asthma is chronic obstructive lung conditions that is condemned of triggers and attacks. Since we now know that asthma has many triggers and causes, well in response to coming in contact with its trigger the mast cells of the immune system, which are found in loose connective tissue, are responsible for releasing vasoactive which are action on vessels, chemical mediators, including histamine, bradykinin, leukotrienes, cytokines and prostaglandins. Chemotactic (produces specific cell movement) chemical mediators released from the mast cells cause neutrophils, lymphocytes and eosinophils to infiltrate the cells of the bronchial lining. These target the respiratory system and cause bronchoconstriction, vascular congestion, vasodilation, increases in capillary permeability, mucosal edema, impaired mucociliary action (removal of mucus and contaminants within the bronchial tree by movement of the cilia inside the bronchioles), and increased mucus production, which leads to an increase in airway resistance. These pathophysiologic factors produce the typical clinical presentation of asthma. (Allergic Asthma and Rhinitis Comorbidity, P.

Asthma is a lung disease characterized by variable and reversible airway obstruction, airway inflammation, and bronchial hyper-responsiveness. Causes recurring periods of wheezing, shortness of breath, chest tightness, and coughing; coughing normally occurs at night or early morning. Asthma affects people of all ages and mostly starts in childhood. In the United States, more than twenty-five million people are diagnosed with asthma and about seven million of these people are children.

To better understand the impact of asthma, a brief overview of the causes (aetiology) and disease progression (pathophysiology) must be shown. As common as asthma is, not much is known about its aetiology, according to findings presented by Subbaroa, Mandhane and Sears (2009, pg. 181-187) in a review from the Canadian

*Biology-Pre Dental Program, Department of Biology, School of Mathematics Science and Engineering, University of the Incarnate Word

Unfortunately, no one actually knows what causes asthma, and hasn’t yet figured out how to cure it. If someone in an individual’s family has asthma then they are more likely to have it.

Childhood asthma impacts scores of youngsters and their families. In fact, the bulk of kids develop respiratory illness before the age of

Asthma is a chronic non-contagious disease that according to the World Health Organization, affects nearly 235 million people throughout the world and is responsible for causing 250,000 deaths per year. In the United Sates, it affects more than 18 million adults and 7 million children. Asthma is characterized by hyperresponsiveness of the lungs to allergens, episodic bronchoconstriction, chronic inflammation of the airways, excessive mucous production, airway remodeling and reduced lung function. Together, these signs produce symptoms of breathlessness, coughing, chest tightness and wheezing attacks (Kudo et al. 2013). Some common risk factors include premature birth (Jaakkola 2006), low birth weight (Liu 2014), maternal cigarette smoking (Burke

The earliest of medical record references on respiratory complications was found in China in 2400 BC. The history of the discovery of asthma as an acute respiratory disorder came to light in 400 BC. The term ‘Asthma’ was first used by Hippocrates in his book ‘Corpus Hippocraticum’ where he also provided a definition for the medical term. A more elaborated explanation stating that asthma results due to the occurrence of obstruction in the bronchitis of the patients was put forth by the famous Greek medical practitioner, Galen in 130-200 BC.