Hereditary Hemochromatosis (HH)

Decent Essays
Register to read the introduction…Hereditary Hemochromatosis (HH) is a genetic disorder in which iron levels in the body build up over time. HH is often known as the iron overload disorder. Hereditary Hemochromatosis (HH) and Hemophilia have a number of similarities when both express an excess of iron build up in the body. In a review article published by the Journal of Clinical Pathology, they compared and contrasted the effects of iron on both the arthopathy of HH and HA, blood disorders that react poorly to the presence of excess ferrous iron…show more content…
During the study, rats, mice, rabbits, and monkeys were used in a variety of ways to run specific tests. In the beginning, female FVIII mice were used to compare characteristics of both rFVIIa and rFVIIa-FP. To compare their findings, all of the dosages were consistent throughout the trials. A total of thirty (30) animals were in placed in each lab group and three of the animals received vehicle to determine a baseline level. Blood samples were taken 2, 5, and 30 minutes and 1, 2, 4, 6, 16, 24, and 48 hours after injection. Some of the other animals that were used (per lab group): eight (8) Rats, three (3) rabbits, and two (2) monkeys. Blood samples from the rats were taken at 5, 15 and 30 min and 1, 2, 4, 8 and 24 hour (hr) increments. Samples of blood were harvested from the rabbits at 1, 5, 10 and 30 min, and 1, 2, 4, 8, 24, 48, 72, 96 and 168 hrs. Blood samples from the monkeys were drawn at 5 and 15 min, and 1, 2, 4, 8, 24, 48, 72, 96 and 120 hrs. This data was analyzed and tabulated into table…show more content…
Each treatment should be treated case-by-case to ensure that the patient is receiving the best possible care. Suggested treatments consist of regular infusions of DDAVP and/or clotting factor, first aid for minor cuts, physical therapy, fibrin sealants and clot-preserving medications. For Hemophilia C, clotting factor XI is available only in Europe and in the United States bleeding episodes are treated through plasma infusions. Clotting factor XI is not available in the United States because Factor XI concentrates are blood products with a concentrated form of Factor XI. Meanwhile, available only in certain areas of Europe, these blood concentrates are made through a series combining thousands of different blood donors. Therefore, the United States only keeps frozen plasma instead. Fibrin sealants work by applying the medication directly to the site of the wound, from there the Fibrin promotes clotting and healing. Clot-preserving medications can also be applied directly to the wound. However, this time the medication preserves the clot from breaking down and assists in ending the
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