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How Do Infections Cause Cancer?

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Infectious agents, such as bacteria and viruses, represent the third largest cause of cancer. Accounting for more than 20% of all cancers worldwide, cancers caused by infectious agents are more common in developing countries where access to medicine and antibiotics is more difficult. However, even in developed countries like the United States, infections still play a role in many common cancers, some which have proven difficult to treat.
Infections that are carcinogenic, such as Hepatitis C and HIV, all share similar characteristics. These hallmarks include their ability to induce persistent inflammation, which can lead to changes to immune cells, and their ability to suppress the immune response, which impedes the immune system’s ability to fight off cancerous cells. Another way some infections, especially viruses, can cause cancer is by directly changing the DNA of their host by inserting their own genomic material into cells. When this happens, innate cancer-fighting mechanisms, like apoptosis, can be hindered. This can lead to the uncontrolled …show more content…

Many viruses can cause persistent infections by establishing niches, making them extremely difficult to treat. An example is Human Immunodeficiency virus (HIV), which has been shown to increase a person’s odds of developing several different types of cancers, such as anal cancer, Hodgkin disease, lung cancer, and even skin cancer. HIV is known for establishing persistent infections and for its inability to be cured. Additionally, symptoms of HIV often emerge months after infections, which can lead to extensive damage of the immune system, a disease called Acquired Immunodeficiency Syndrome (AIDS). Because of this, having HIV greatly increases a person’s risk of getting several different types of cancer as the immune system cannot recognize and target cancerous

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