Hutchinson Gilford Progeria Essay

Hutchinson-Gilford Progeria Syndrome other wise known as “Progeria”, or “HGPS”, is a very rare, and fatal genetic disorder characterized by an appearance of accelerated aging in young children. The rate of aging is accelerated up to seven times that of a normal life span in first 13 years of life. Progeria comes from the Greek word (πρό), “pro” meaning premature and (γῆρας), “gerias” meaning old age. While there are different forms of Progeria, the most sever form of progeria is formally known as Hutchinson-Gilford Progeria Syndrome, which was named after the doctors in England: in 1886 by Dr. Jonathan Hutchinson who described the syndrome, and by Dr. Hastings Gilford who independently discovered it in 1904 (Jameson).

Edward’s Syndrome is the second most common of the trisomy disorders, following Trisomy 21 (Down syndrome), but does not happen very often in developing fetuses. It occurs once in every 5,000 live-born infants, and most of these infants are female. Many times, the fetus that is affected with this disorder will not make it the full nine months. Other times, if the infant is born with the disorder they will only live for about a month or less. This disorder is seen more often when older women are pregnant, rather than young mothers. 10 percent of individuals with trisomy 18 will live past the first month, and some can even live into their twenties with severe developmental conditions and disabilities. The actual

Once called the “leprechaun’s disease”, Hutchinson-Gilford Progeria Syndrome was first described in 1886 by the English surgeon Jonathan Hutchinson and by Hastings Gilford in 1904. The main reason why it took so long to find the gene for Childhood Progeria is that it only affects about one baby in every four million to eight million in the world.

People with Progeria are very short in stature and have thin limbs, prominent joints, and hip dislocations (Werner).

Francis Howard Greenway was born on the 20 November 1777 and lived near Bristol, England. He was an only child and lived with his mother and father.

Robert Guthrie, MD, Ph.D. was born on June 28, 1916 in Marionville, MO and died on June 23, 1995 in Seattle, WA, at the age of 78. He was survived by his wife, Margaret, of 53 years and their six children. Dr. Guthrie attended the University of Minnesota where he earned his Medical Degree in 1942 and his Ph.D. in bacteriology four years later. In the earlier part of his career, Dr. Guthrie was a cancer scientist at the Roswell Park Cancer Institute in Buffalo, NY. In 1947, during his time working in Buffalo, Dr. Guthrie and his wife gave birth to their second son, John, who was born with a mental handicap. According to research, Dr. Guthrie had been motivated by his sons’ condition to pursue research solely focused on the prevention of mental retardation. Furthermore, in 1958, when his niece was born and diagnosed with Phenylketonuria, also known as PKU,

There are many ways to help children with progeria and their families. Whether you choose to donate time or money, everything you do is appreciated. Money donated can go to organizations such as the Progeria Research Foundation. This money will go to help fund research and help families manage with medical bills. Volunteering your time and meeting children with progeria is something more people are able to and allows you to meet and connect with these children.

Progeria, also known as Hutchinson Gilford Progeria Syndrome, and Progeria syndrome, is an extremely rare genetic disease wherein symptoms resembling aspects of aging are manifested at a very early age. The Progeria come from the Greek words “pro” meaning “before” and “gēras” meaning “old age”. The disorder has a very low incident rate, occurring in an estimated 1 per 8 million live births. Those born with Progeria typically live to their mid teens and early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited. Although the term Progeria applies strictly to all diseases characterized by premature aging symptoms, and is often used as

Some ways to detect Progeria are genetic tests of the patient’s blood and clinical exams. Furthermore, the major signs begin developing when the child is around eighteen to twenty-four months old and he will experience accelerated aging even though he was born looking normal. One major symptom is hair loss. Patients are born with hair texture and color, but around six months to two years, the hair begins to fall out. Then, from two to three years, they are usually bald, but might have some thin, light hair. Loss of eyelashes and eyebrows are also experienced. Along with hair loss, these children grow slowly resulting in a shrunken physique and minimal weight gain. For males, their approximate height and weight are 40 inches and 25 pounds; but females are about 32 inches and 20 pounds. In When Good Things Happen to Bad People, doctors have stated these kids will "grow to be very short," and "would never grow much beyond three feet."( Kusher 1-2) Moreover, there are distinctive physical traits in the face and body. "By the second year of life, there is also under development (hypoplasia) of the facial bones and the lower jaw." ("Hutchinson-Gilford Progeria") Also, "the face appears disproportionately small in comparison to the head, and bones of the front and the sides of the skull (cranium) are unusually prominent." ("Hutchinson-Gilford Progeria") Some other characteristics observed in the face are a thin

Percy Aldridge Grainger was born on the 8th of July 1882, in Brighton, Melbourne. As an only child of John and Rosa Grainger he began learning music at the age of 5 with his mother Rosa. Grainger’s music studies many aspects of life and artistic persona, making him a unique Australian musician. He had a diverse musical career including pianist, composer, folklore collector, musical arranger, ‘free musician’ and inventor, making him one of Australia’s greatest musicians of all time. Whilst living in Australia Grainger came before the public eye as a pianist at a concert at Melbourne’s Masonic Hall during 1894. His life intention was to communicate every feature of his life to the public and soon after his creative achievement was seen

Signs and symptoms according to Medline Plus: mottling, excessive crying, irritability, excessive sucking, poor feeding, poor weight gain, hyperactive reflexes, trembling, increased muscle tone, raid breathing, vomiting, diarrhea, seizures, sleep problems

I infer several conclusions from Smith’s definition and analysis of sympathy. First, sympathy is a mode of perception. The “eye of the mind” or the imagination perceives the situation witch elicits primary sentiments and secondary agreeable or disagreeable sentiments which are the basis of moral judgement. Secondly, I conclude from Smith’s propositions that the mind is a passive recipient, therefore moral knowledge is a by-product of external stimuli. In other words our external sense stimuli provoke a change in our minds, from which our imaginations produce sentiments by which we judge the propriety or merit of another’s conduct.

Progeria is a rare, fatal, genetic condition that comes from the Greek word progeros meaning prematurely old. In the greek language, the word ‘pro’ means before and the word ‘geras’ means old age. Another name for progeria is Hutchinson-Gilford Progeria Syndrome. Hutchinson-Gilford Progeria Syndrome (HGPS) was first described in 1886 by Dr. Jonathan Hutchinson and also in 1897 by Dr. Hastings Gilford in 1897 – both in England.

Hutchinson-Gilford progeria syndrome is a genetic disorder that causes the appearance of young children to intensely and rapidly age and have illnesses that are typically associated with the elderly. Progeria is caused by a mutated gene called the LMNA and this gene produces a protein called lamin-a. Lamin-a is an important protein because it is what’s responsible for creating the shapes of the nucleus in cells. It’s also responsible for supporting the nuclear envelope, which is the membrane that surrounds the nucleus. Progeria is caused because of the creation of an abnormal version of the lamin-a protein.

The signs and symptoms of DiGeorge syndrome vary from mild to severe. Symptoms can differ depending on how highly the affected areas are and the severity of those defects. Some signs of symptoms can be noticed at birth, while others are not noticeable until late childhood. Some symptoms caused by DiGeorge syndrome affect facial appearance, such as low set ears, underdeveloped chin, small