Human Kidney Function
Renee King
TA: Oliver
Biology 3U03
November 24, 2016
Treatment with water, caffeine, alcohol, and gatorade and the effects on urine output, pH, Na+ excretion, and solid excretion were tested at 30 minute intervals for 2 hours. It was found that urine production for each treatment group increased after 30 minutes, increased further after 60 minutes, and then began to decrease. Mean increases in urine production were only significant for Gatorade in the first 90 minutes (an increase of 40% at 30-60 minutes, and a decrease of 73% at 60-90 minutes) and for caffeine over 60-90min (a 48% decrease). The average pH for each treatment group became more acidic by 90-120 minutes. Mean differences over each time
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A decrease in solute concentration caused by consuming water inhibits ADH and causes the distal tubule and collecting duct to become impermeable to sodium and causes the concentration to increase in the urine (VanPutte et al., 2014). Once the volume load is excreted (327.01mg/kg of sodium), sodium concentration becomes normalized and decreases. Caffeine inhibits the reabsorption of sodium by inhibiting ADH, thereby stimulating an increased Na+ and water excretion, as water is drawn into the tubule due to the high Na+ concentration along its osmotic gradient. Since alcohol also inhibits ADH, it will also cause Na+ to be excreted. The two follow a very similar trend, but the mean differences in sodium excretion are not significant. A study done by Maughan et al. (1994) showed that urine osmolality was highest in individuals over the first hour after consumption, and then began to fall as the body begins to restore water and electrolyte balance. These drinks cause a direct consumption of electrolytes. This is reflective of the pattern seen in Gatorade treatment groups, where Na+ concentrations increased by 82% by 60-90 minutes and then began to drop. The significant difference in the total sodium excreted by the water treatment groups may be due to the small consumption of each of the other three treatments, as mentioned above, which don’t have as large of an affect unless consumed in …show more content…
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The patient in “The Red Hat Hikers” scenario is suffering from hyponatremia. Hyponatremia is defined as a serum sodium level of less than 136mEq/L. Sodium is an electrolyte that is found predominately in the extracellular fluid, and it is the chief regulator of water in the body. Sodium is also important for muscle contraction, nerve impulses, acid-base balance and chemical reactions that occur inside the cell (McCance & Huether, 2014). Normal sodium levels in the body are maintained by the kidneys and the hormone aldosterone. Aldosterone is secreted by the adrenal cortex at the completion of the renin-angiotensin-aldosterone system, and it helps stimulate the proximal tubules of the kidneys to reabsorb sodium and water. The anti-diuretic hormone (ADH) also indirectly affects sodium levels because it regulates water balance in the body (McCance & Huether, 2014).
(Graham, 1998) This shows the importance of caffeine in endurance sports such as cycling, running, and soccer which require a great deal of physical stamina in order to compete successfully. Studies also show that caffeine has very little affect on athletes requiring quick burst of energy such as sprinters and swimmers. Also caffeine has been known to decrease fatigue in athletes, which plays a physical as well as psychological role in the performance of an athlete.
The purpose of the experiment was to help us better understand how water, Coke and Gatorade effected the renal system. The goal was to test and see if my hypothesis were correct regarding the urine specific gravity, urine flow rate, and presents of reagents using the Labstix. My hypothesis for this experiment was that the Gatorade drinkers will have the highest urine flow rate and that non-drinkers would have the highest urine specific gravity. Water is hypo-osmotic and coke contains a high amount of sugar making it hyperosmotic relative to plasma. Gatorade consists of large amounts of electrolytes making it iso-osmatic relative to the plasma. Based on these characteristics of the consumed substances, we are able to study the hormonal effects on the average UFR and USG.
Caffeine is a natural central nervous system stimulant. It is considered a drug that if is overly consumed can be dangerous for one’s body. Caffeine is a temporary energy booster that improves mood and alertness for most people, mainly athletes. It can be an eye-opener in the morning, could be drunk or eaten on practice brakes, and for some, it just became a habit that they cannot go through a day without a cup of coffee before exiting their doorways. Furthermore, it requires good health and stamina for athletes to perform throughout the game, particularly the one in teams,
It is evident that healthy adults running a marathon that replaces with only free water will run into pathophysiology challenges that will affect performance. Adequate fluid intake is crucial for prolonged, strenuous exercises to maintain adequate hydration, thermoregulation, maintain plasma volume and avoid dehydration (Duvillard et al, 2004). Although athletes are prone to hydrate as much as they can during extensive marathons, research shows that fluid replacement with only free water or even hypotonic beverages can be detrimental.
iii. the mechanisms by which a single session of vigorous exercise affects the diuresis produced by the water load (subject C).
Considering a diagnosis of dehydration, along with the fact that Joe seems to be consuming a lot of caffeine, a diuretic that causes fluid loss, the student may suggest testing Na, Ca, and other electrolyte levels in the blood, as well as levels of caffeine or other metabolites in the blood and urine. This latter information may help the student determine or at least estimate Joe’s caffeine intake.
Thesis: Caffeine can have many different effects on the body depending on the amount of consumption.
An independent samples t-test was conducted to examine the difference between experimental conditions on test performance. The results indicated a significant difference between participants who consumed the caffeinated beverage and participants who did not, with participants in the caffeinated group (M = 7.64, SD = 2.41) performing worse than participants in the non-caffeinated group (M = 9.81, SD = 3.16), t (97) = 2.14, p < .05.
Avoid drinking caffeinated drinks such as coffee, tea, energy drinks and colas. These fluids can contribute to bladder irritation.
Caffeine is a very popular stimulant among athletes because most believe that it provides energy, increases alertness, and quickens reaction time. When in beverage form,
As well, sport drinks have the ability to provide a subject with an increased amount of endurance for their exercise. One reason why sport drinks have this capability is due to the carbohydrates found in the beverages. These carbohydrates exist as either of two sugars, sucrose and glucose-fructose, which provide the energy for the body that makes sport drinks better to use during exercise than water (Tsintzas 155). Carbohydrate consumption allows athletes to work harder for longer periods of time and to feel better while doing the exercises. A recent study determined that runners who had only water to drink lost speed during the race compared to those who had sport drinks. Also, performance time was faster in runners who consumed the sport drinks as opposed to water. It was only during the final 17.2 kilometres of the race that the performance times began to differ and the runners who drank the sport drinks ran faster (Tsintzas 156). Furthermore, the exercise intensity was higher towards the end of the race from those runners who had the sport drinks. As with most performance enhancing implements, sport drinks have potential drawbacks.
Dehydration is the primary reason for various health issues. Elevated utilization of coffee and alcohol just adds to the problem. Can you recall the last time you had six to eight glasses of water during the day?
So in other to get the answer to this question, and exactly happens in your body after you consume one of the drinks, researchers from the Mayo Clinic researcher Anna Svatikova and her colleagues recruited 25 volunteers, made a experiments
Dehydration is the most common fluid and electrolyte imbalance in the elderly, which can be avoided easily. The author has seen many elderly patients has been admitted to the hospital with issues related to dehydration. As the age increase the thirst threshold deprives resulting in a reduced Glomerular filtration rate by 50-63% from the age of 30-80%. The risk of dehydration is exacerbated by co-morbidities, poly-pharmacy overdose, physical and mental disability (Sahota et al., 2014). Dehydrated elderly people (serum osmolality >135) had 40% higher risk of 8years mortality and doubled the risk of increased new disability over 4years compared to well-hydrated older people (Stookey et al., 2004). Some of the studies