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Lansoprazole

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Introduction

The stomach naturally produces acid, which is mainly responsible for food digestion and destruction of any foreign pathogen or bacteria ingested with food. Acid is secreted by stimulating the partial cells located in the inner lining of the stomach to release acid in response to a stimulant of food ingested, sight of food, smell, or taste. This acid secretion renders the stomach pH to be very low, this strong acid is an irritant to the stomach. In protection of the stomach, a mucus layer is present to shield the lining of the stomach from damage caused by the acid. When this protective mucus layer is damaged, ulcers are formed and even to the point of perforation of stomach (hole that causes a bleed in the stomach).

This damage …show more content…

But on the contrary, based on limited evidence of case control studies, the author of pharmacokinetic drug interactions profile of PPIs stated that omeprazole has a considerable potential for drug interaction than Lansoprazole5. This claim is based on the fact that omeprazole has been available longer than other PPIs5 such as Lansoprazole. This is also consistent with the pharmacological study done on Lansoprazole, which concluded that the properties of Lansoprazole differ greatly from Omeprazole with respect to their pharmacological properties and chemical structures8. For example, Lansoprazole acquires a trifluoroethoxy group8 as a result of the addition of fluorine, which appears to improve its pharmacological activity than to Omeprazole. Therefore, since omeprazole is first discovery of PPIs is considered to have more drug interactions, after refining its properties lead to the discovery of Lansoprazole acquires a better pharmacological …show more content…

This is based on case control studies mentioned in the article on long-term use of PPIs. In other words, patients who are chronically using PPIs must watch their intake of PPIs to prevent long-term adverse effects leading to osteoporosis causing bone fractures. The correlation was shown as a result of a high variable effect of acid suppression on calcium absorption.

Researchers tried to investigate the difference between proton pump inhibitors and found consistent common pharmacology between all drugs in this class4 (Omeprazole, Esosenoprazole, Lansoprazole, Pantorapzole, and Rabeprazole) that were compared in this study. In this article relating to the clinical and pharmacological basis stated that Lansoprazole is equipotent to Omeprazole as well as Pantoprazole. This finding is still very consistent with previous articles supporting the similar potencies and effectiveness of

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