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Ldb Case Study

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Four studies focused on determining a link between CVD risk, LDL particle size and number (LDL-P), and total cholesterol content within the body. For the first study completed by Toth et al11, CVD incidence was compared to LDL-P thresholds by analyzing the frequency of CVD events during a six-month period. The researchers considered the baseline LDL measurement as the day in which the most recent LDL-P value was gathered prior to a CVD event, referring to it as the index date, and the researchers assessed outcomes throughout the entire study period. CVD events were verified utilizing the ICD-9 diagnosis codes and the study ended if the patient lost their health plan eligibility, data was no longer available, or the patient died at…show more content…
After gathering data, it was determined that less patients in the LDL-P group suffered from a CVD event during each of the three follow ups with a total relative risk reduction of 25%. A major limitation of this study is that it focused on patients that were all on a large US commercial health plan and thus excluded those that were on different health plans, did not have insurance, or were outside of the US but could have had pertinent results that could tie into the study. Additionally, the study did not consider certain risk factors such as race or family history that could have impacted the rate of CVD events during the course of the study. Lastly, the researchers of this study did not assess patient adherence to the various lipid lowering medications which could have altered the results if medications were changed or doses were altered.11 The second study completed by Mora et al12, known as the Multi-Ethnic Study of Atherosclerosis and completed as a multi-center cohort through the National Heart, Lung and Blood Institute (NHLBI), gathered data on carotid intima-media thickness and lipoprotein measurements to compare small and large LDL particles to the thickness of the carotid intima-media to determine cardiovascular risk based on particle size. The methods started with gathering carotid atherosclerosis measurements that were interpreted through
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