Levifloxacin Case Study

Amoxicillin can interact with medications such as Diuretics, oral contraceptives, Probenecid, Tetracyclines, and Warfarin (Woo, 2012).

Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections.

Last QDRR in 5/30/17 indicates that patient is free from poly-pharmacy but he is not free of potential drug interaction:

Relevant interactions: Diuretics - hypokalemia, predisposing patient to digitalis toxicity. Antacids - decreased absorption of oral digoxin.

Here’s a list of medications that are known to interact with this drug. There may be others not listed. If you have any questions, ask your

The use of strong cytochrome P450 3A4 inhibitors (e.g., ritonavir) with Symbicort may cause increased systemic corticosteroids. Formoterol, a component of Symbicort, can produce significant cardiovascular effects, such as flattening of the T-wave, prolongation of the QTc interval, and ST depression. In addition, because of the action of formoterol on the vascular system, taking with monoamine oxidase inhibitors and tricyclic antidepressants should be cautioned. Furthermore, beta-blockers, including eye drops may not only produce severe bronchospasm in patients with asthma, but may block the pulmonary effect of the beta-agonists, such as formoterol as well. Finally, caution is recommended when administered concomitantly with non-potassium-sparing

Zohydro offers a hydrocodone extended release formulation (12 hrs effect) without acetaminophen and its adverse effects as liver toxicity and possible ototoxicity. On the other hand, due to its high hydrocodone dose in just one pill could be very dangerous especially

Among SSRIs, paroxetine, fluvoxamine, and fluoxetine are mainly metabolized by CYP2D6. Sertraline, citalopram, and escitalopram are mainly metabolized by CYP2C19. There are CPIC guidelines for fluvoxamine and paroxetine regarding CYP2D6, also for citalopram, escitalopram, sertraline regarding CYP2C19. These guidelines suggest the reduction of the dose or alteration of medication if the patient has a poor metabolizer phenotype. Since this patient is a poor metabolizer for both CYP2D6 and CYP2C19, patients may experience side effects from relevant SSRIs due to higher plasma concentration, we may need to avoid using the above SSRIs. Additionally, she tried paroxetine, fluoxetine, and sertraline in the past which were all not successful, we would like to avoid those as well.

It also helps with the prevention of PCP in HIV-positive patients, but should be used cautiously due to the incidence of adverse reactions. This drug is also active against many strains of gram-positive pathogens including: Streptococcus pneumoniae, Staphylococcus aureus, Group A beta-hemolytic streptococci, Nocardia, Enterococcus. It also has activity against many gram-negative pathogens, such as: Acinetobacter, Enterobacter, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Shigella, Xanthomonas maltophilia, and Haemophilus influenzae, including ampicillin-resistant

Make sure to take at same time every day. Can cause loss of appetite. Can cause thyroid problems, need to monitor thyroid levels. Can cause unexplained weight loss.

The health issues listed here are just a glance at what this drug can do to one’s health.

Medications that can cause interactions include anticoagulants, probenecid, bisphosphonates, angiotensin-converting enzyme (ACE) inhibitors, anticoagulants (Warfarin), antiplatelet medicines (Clopidogrel), aspirin, corticosteroids (Prednisone), heparin, other NSAIDs (Ibuprofen), Rivaroxaban, or Selective Serotonin Reuptake Inhibitors (SSRIs) (Fluoxetine) due to the risk of stomach bleeding may be increased. Bisphosphonates (Alendronate), Cyclosporine, Hydantoins (Phenytoin), Lithium, Methotrexate, Quinolones (Ciprofloxacin), Sulfonamides (Sulfamethoxazole), and Sulfonylureas (Glipizide) side effects may be increased by Naproxen. The effectiveness of Angiotensin-converting enzyme (ACE) inhibitors (Enalapril), Beta-blockers (Propranolol), or diuretics (Furosemide, Hydrochlorothiazide) may be decreased by Naproxen (Lexi-Comp,

Adverse reactions to drugs are common and almost any drug can cause an adverse reaction.

Adverse reactions to this medication are migraine, speech disorders, rhinitis, sinusitis, hyperglycemia, elevated liver function, elevated serum creatinine level, pancytopenia, bronchitis, dyspnea, toxic epidermal necrolysis, anaphylaxis, elevated creatine kinase, generalized pain, and infection. Nursing considerations with this medication is to have the patient swallow the whole tablet and not to chew. Watch for aspiration while watching the patient take the medication. Educate the patient about the medication and inform them to notify a physician if bleeding

Other side effects include cloudy urine, proteinuria, irregular heartbeats, and chest pain. Angioedema involving the extremities, face, lips, mucous membranes, tongue, glottis or larynx has been seen in patients treated with ACE inhibitors, including captopril (Capoten, 2014). If these effects happen nurses should be ready to administer epinephrine to reduce swelling. Other adverse effect according to Karch (2014) include, “CV: Tachycardia, angina pectoris, heart failure, MI, Raynouds syndrome, hypotension in salt-or volume depleted patients.”