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Literature Review On Infliximab

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Literature review, showed that Infliximab in patients with moderate to severe UC, is an effective treatment. This effectiveness was confirmed by increasing in clinical response and remission rate on induction and maintenance therapy, compared to placebo. In addition, it was found that infliximab, reduced the need for surgery and hospitalization, in severe acute and refractory UC patients. The findings also showed that, remission is achieved faster in patients who have used Infliximab early stage of disease than patients who began Infliximab treatment later [15]. 3.2 Outcomes- Health status The utility value for each health state, extracted from Arseneaus ‘study that conducted with time trade off method. The utility value for the remission, …show more content…

According to the World Health Organization (WHO) guidelines for choosing cost –effective intervention, an intervention with ICER value less than one GDP per capita, would be considered very cost- effective, between one to three times of GDP per capita, will be cost- effective and more than three times of GDP per capita, considered as not cos -effective(38). Therefore, by considering ICER value of analysis as 50.6 GDP per capita, infliximab treatment is not cost–effective option in comparison with conventional treatments. According to the Published literature on sensitivity analysis in this case, ICER value would be affected by some factors such as: Patient’s weight, time horizon, treatment effect, and utility value [20, 21, 37]. In this study, we performed a one-way sensitivity analysis via change in price of infliximab, as we believe cost of infliximab is the most important factor that affects ICER value. Our result indicated, by 90% decrease in price of infliximab, the ICER value will be less than 3 time of GDP per capita and infliximab could be cost-effective treatment

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