The Genetics of Lung Cancer
Catherine Hayworth
BIO 355A/357A
June 14, 2012
Colorado Christian University
Cancer can be one of the hardest battles that one must face, whether that battle is lost or won, it changes the lives of everyone involved. Lung cancer is one of the most diagnosed cancers and it affects the lining of the lungs and the ability to breathe. Lung cancer is the number one killer of men and women than any other cancer worldwide. This cancer is mostly found in smokers and this is why professionals are targeting this population for testing for diagnosing early and possibly saving a life (www.ncb.nlm.nih.gov). Lung cancer refers to the malignancies that originate in the airways or pulmonary parenchyma. It is
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According to the National Human Genome Research Institute (NHGRI) the researchers identified a large region on human chromosome 6 that conferred greater lung cancer risk in families with many affected individuals. Subsequent painstaking analysis to pinpoint the source of the elevated risk now has paid off with the identification of the precise culprit, a gene called RGS17. Researchers conducted fine-mapping of the suspect region of chromosome 6 in members of families in which five or more individuals over multiple generations were diagnosed with lung cancer. The region contains approximately 100 genes. Precise computational analysis uncovered similar variants in the DNA sequence for members of the families with lung cancer. These variants, called single nucleotide polymorphisms (or SNPS) directed the researchers to the RGS17 gene. The conclusions of this analysis are that RGS17 plays a major role in lung cancer susceptibility, and individuals who carry the higher-risk version of this gene have an increased susceptibility to lung cancer when exposed to environmental risk factors, such as smoking. While the research showed that RGS17 is an important gene for lung cancer susceptibility in families with a high incidence of lung cancer, the researchers did not see any
Lung cancer is the most commonly diagnosed cancer in the world, according to the World Health Organisation. In the UK, it 's the second most-frequently occurring cancer among men (after prostate cancer), accounting for 1 in 7 new cases, and the third most-frequently diagnosed cancer in women (after breast and bowel cancer) accounting for about 1 in 9 new cases. However, numbers have dropped considerably in recent times, by about 16% in the last decade alone.
Lung cancer is the most common cancer-related cause of death among men and women. Lung cancer can be undetected for many years causing it to become more dangerous and possibly fatal. There is not cure for lung cancer or any cancer, but if detected in an early stage the lung cancer can be detected, treated, and hopefully terminated. There are many new and developing treatments being tested now that may save lives in the future. Through understanding what the lung cancer is, doctors can easily diagnose and assess cancer patients.
A common form of cancer that is very popular today is lung cancer. Lung cancer is a very dangerous form that can cause problems in simple body functions. These simple body functions are short breath and general fatigue. Lung cancer is commonly formed from smokers that has been exposed to that activity for numerous years. Lung cancer can also be spread by being exposed to asbestos or other pollutants. This form of cancer has many risk factors to it. These risk factors are high levels of air pollution, arsenic drinking water, and radon gas. Radon gas is a gas that is highly radioactive and is very sensitive to the body. Once radon is exposed to the body, it has a very high respiration rate which initially divide its radioactive cells- causing more significant damage to the body.
Lung Cancer, like any other type of cancer, is the uncontrollable growth of cells in the lung tissue. The main causes that contribute to lung cancer include inhaling carcinogens (basically, smoking), exposure to ionizing radiation, viral infections and even air pollution. These factors basically damage the tissues lining the bronchi in the lung, leading the cancer to develop further (Vaporciyan & Nesbitt JC, 2000). Primary lung cancers that develop in the epithelial tissues of the lung are known as carcinomas and claim the top spot in terms of leading cancer-related death causes. As of 2004, lung cancer
Lung cancer is a cancer (malignancy) that originates in the tissues of the lungs or the cells lining the airways. Lung cancer originates when normal lung cells become cancer cells, usually after a series of mutations, and begin to divide out of control.
The leading cause of cancer death for both men and women in the United States and worldwide is lung cancer. Lung cancer is responsible for thirty percent of cancer deaths in the United States. The deaths caused by breast cancer, colon cancer and prostate cancer combined do not add up to the deaths that lung cancer causes. In 2007, 158,683 people, 88,243 men and 70,354 women died from lung cancer in the United States (Eldridge, 2012). Out of the 158,683 people that died from lung cancer in 2007, 135,000 of them died of lung cancer caused by smoking cigarettes. The overall survival rate of those with lung cancer is at about fifteen percent.
Lung cancer is a tumor that affects either one or both of the lungs.A primary cancer begins in the lungs and a secondary cancer begins in another place in the body and makes its way up towards the lungs. Lung cancer is the 5th most common cancer. In Australia 59% of males were diagnosed were as 41% of Australian females were diagnosed.
Today we will be focusing the genes that cause Lung Cancer. There are actually multiple genes that can lead to lung cancer, however, one of the most common ones is the EGFR gene. The EGFR gene is going to be the gene we are going to talk about today. I know we are getting very narrow, but after all, I have four minutes to explain the cure for lung cancer. It is just to0 vast of a subject. That is why we are going into detail for a specific area of lung cancer. This is all about targeted Therapy. So what is this EGFR gene. EGFR stands for Epidermal growth factor receptor. It is composed of C22H23N3O4. It has a molar mass of 393.436 g/mol. It is located on Chromosome 7 of our cells, with a specific position of 7p11.2. It is responsible for controlling the rate in which cells grow and divide. When this gene is turned on, it signals cells to grow and divide. When it is turned off, cells do not grow and divide. It is programmed to turn and off at a consistent rate. When this gene is born wrong, mutated, or damaged, it constantly turns on. This causes cells to grow and divide at rapid rates without dying. These cells that grow are cancer cells. As more and more of these cells grow, it forms a tumor. We already know what those
Lung cancer is a type of cancer is found in men and women lung cancer have something to do with your lungs. Your lungs which help pump oxygen into your body and also release carbon out of your body which helps you live because you need oxygen. Lung cancer is a common cancer in ages 60 and up it can also be found in any age but is most commonly in 60 year olds and older. Lung cancer is the leading cause of cancer deaths in the U.S. in both men and women. Lung cancer is also one of the most preventable kinds of cancer, but smoking is mainly the leading cause of lung cancer.
Lung Cancer is one of the most common type of cancer that is affecting a lot of people in the present days. Smoking Cigarette is known as the principal risk factor for development of lung cancer, but there are other causes as well. People usually look for various information regarding this over the internet which is also filled with some misconceptions regarding this disease. Here is a list of some common myths regarding lung cancer that require to be busted for better knowledge:
Lung cancer has been the most common cancer in the world for several decades. The 2012 International Agency for Research on Cancer (IARC) estimate was 1.8 million new cases which constituted 12.9% of the total number of new cancers diagnosed worldwide. Fifty eight percent of which occurred in the less developed regions. Lung cancer remains the most common cancer in men worldwide (1.2 million, 16.7% of the total) with the highest estimated age-adjusted incidence rates in
Risk factors that increase the chances of developing lung cancer include smoking, exposure to secondhand smoke, exposure to radon gas, exposure to asbestos or other chemicals, and family history of lung cancer.1 Above all others, cigarette smoking is the most strongly correlated and preventable risk factor in lung cancer development.1,2 Approximately 80-90% of the deaths from lung cancer are the result of smoking, accounting for 90% of the lung cancer deaths in men and 80% of the deaths in women.1,2 Cancer cells are formed by DNA-mutating
Lung cancer is a disgusting disease that many have died from. It is the largest single cause of cancer deaths in America. It causes more deaths than colon, breast and pancreatic cancer combined. People shouldn’t have to suffer from this disease. We have to prevent any more cases of lung cancer.
The American Cancer Society (2015), reports that smoking accounts for 30% of all cancer deaths in the United States, including about 80% of all lung cancer deaths. “Lung cancer is the leading cause of cancer deaths in both men and women’’ and is one of the hardest cancers to treat. Cigarettes, cigars, pipes, and smokeless tobacco all cause cancer. Not only does smoking cause lung cancer but it causes other cancers as well. Smoking can also cause many other lung diseases that are just as bad as lung cancer including COPD and emphysema.
Lung cancer is the uncontrolled growth of abnormal cells in one or both lungs. The abnormal cells divide and grow into tumors. The tumor intrudes mostly in the air passages. 7.6 million people die of cancer worldwide each year, but 1,370,000 people die because of lung cancer (Medicalnewstoday). In the United States, 158,080 people are estimated to get lung cancer in 2017. Men are more likely to develop lung cancer than women. African American men are 28% more prone to getting lung cancer than white men and African American women develop lung cancer equally as white women, despite the fact they can smoke fewer cigarettes. (American Lung Association).