Nicotine Cell Proliferation And Invasion

What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three main subtypes, namely adenocarcinoma, squamous-cell carcinoma and large-cell carcinoma (Longo & Harrison, 2012). Lung cancers can be diagnosed by chest X-ray, computerised tomography (CT) scan, positron emission tomography-computerised tomography (PET-CT) scan, bronchoscopy and biopsy (Nhs.uk, 2015). Unfortunately, lung cancers are often diagnosed at the later stages. This is due to the unrecognisable symptoms and warning signs at the earlier stages. NSCLC are often diagnosed at stage IV which accounts for 30-40% of cases whereas 60% of SCLC is diagnosed at stage IV. Lung cancer usually originates from the cells lining the bronchi, bronchioles and alveoli. Carcinogens especially tobacco smoke will alter the gene expression of the normal human lung cells, resulting in cell mutation. The proto-oncogenes will be converted to mutated form, oncogenes. Mutation leads to the decreased expression of the tumour suppressor genes. This results in uncontrolled cell proliferation, cell

Lung Cancer, like any other type of cancer, is the uncontrollable growth of cells in the lung tissue. The main causes that contribute to lung cancer include inhaling carcinogens (basically, smoking), exposure to ionizing radiation, viral infections and even air pollution. These factors basically damage the tissues lining the bronchi in the lung, leading the cancer to develop further (Vaporciyan & Nesbitt JC, 2000). Primary lung cancers that develop in the epithelial tissues of the lung are known as carcinomas and claim the top spot in terms of leading cancer-related death causes. As of 2004, lung cancer

Cigarettes don’t only cause lung cancers but can also cause other problems to the heart and blood vessels. Some other cancers associated with smoking include larynx, esophagus, bladder, kidney, pancreas, stomach, and some other organs.

Smoking can bring about lung infection by harming your airways routes and the little air sacs (alveoli) found in your lungs. Smoking can bring about lethal infections, for example, pneumonia, lung growth and emphysema. Additionally smoking causes 83% of deaths from chronic obstructive pulmonary disease (COPD) and smoking causes 84% of deaths from lung cancer (NHS , 2017) . However, there is a considerable measure of terrible illnesses connected to smoking cigarettes. Illnesses like throat malignancy, mouth tumour, bladder growth, lung growth, constant bronchitis, emphysema, and coronary illness are altogether brought about by smoking. Also smoking is addictive. Nicotine is the addictive substance

Cancer is defined as a disease caused by an uncontrollable division of abnormal cells in a part of the body. Cancer can be caused by many variables in one’s environment and the variables that are more likely to cause cancer are often referred to carcinogens. Carcinogens are harmful factors that can increase one’s chance of developing a form of cancer. Carcinogens can be anything from ultra violet rays to dust particles from wood; tobacco is one of the most well-known carcinogens because it increases one’s chances of developing lung cancer by a stagger amount. The reason tobacco has the ability to make such an impact is because tobacco contains more than 70 carcinogens altogether. When it comes down to it, the carcinogens are all working together

Lung cancer can be caused by multiple factors and many factors can work together to cause someone to have lung cancer. Besides smoking, radon, secondhand smoke, the environment and someone’s occupation can all cause lung cancer. As we already know smoking is the number one cause of lung cancer cases worldwide and over forty-three million people just in the United States smoke cigarettes. There are more than fifty chemicals in tobacco smoke that are ingested each time someone smokes. Some of these chemicals include benzene (which can be found in pesticides and gasoline), Formaldehyde (which preserve dead bodies), pesticides (which are found on lawns and gardens) and Tobacco-specific N-nitrosamines (Martin, 2012). When a person inhales the chemicals in cigarettes, they inhale thousands of poisons, toxic metals, and

Although many people have heard about lung cancer, they don't know that there are two major types of lung cancer. The types of lung cancer are non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). NSCLC breaks down into three different types and approximately makes up 85-90% of the cancers that patients are diagnosed with. The first type of NSCLC is adenocarcinoma. This type of cancer is usually found in smokers however it is the most common lung cancer found in nonsmokers. This cancer typically attacks younger adults and targets women. This cancer tends to develop on the outside layers of the lungs and it can be found before it spreads throughout the body. The second type of NSCLC is squamous cell carcinoma. This cancer is linked to smoking and forms in the inner airways of

Cancer results from abnormal, unregulated cell growth which can create physiological impairments in body tissues (1). Two adverse characteristics of cancer cells include the ability to invade other tissues and the inability to die (2). Cells generally become cancerous due to changes in gene expression and subsequent errors in protein function (2). These faults in genes and physiology can be caused by mutations which can result from exposure to carcinogens. One of the most common substances associated with carcinogens (though not carcinogenic itself) that promotes cancerous growth is nicotine (3). Nicotine has been shown to stimulate growth, promote the creation of blood vessels (angiogenesis), and prevent cell death through nicotinic acetycholine receptors (nAChRs)(3). In mice, for example, nicotine increased levels of angiogenesis by altering mechanisms involved in a heightened response of the COX-2, prostacyclin, VEGFR-2, MMPs, uPA, and e-NOS protein activity (3). These increases in cell sensitivity to these particular factors stimulated by nicotine promoted cell growth and migration to other tissues (3).

Lung cancer is a very common to be diagnosed with and harmful to anyone who is exposed to many resources around the world: smoking (first hand and second hand) and pollution. Any resource that is made up of chemicals that are exposed into the air that people breathe, give the risk of affecting others with lung cancer. However, since smoking is the most popular way to cause lung cancer, many people are exposed to it from either firsthand or second hand. First hand smoking is when the person being affected is indirect contact with the source that is giving off the toxins, while secondhand is when the one being affected is not directly connected to the main source. Either way the chemicals and toxins that come from harmful resources soon will build up and affect one’s normal body

Lung cancer occurs due to cells in a person’s lungs that multiple at a rapid pace, which form a malignant tumor. These tumors in the lungs take away important necessities such as oxygen, and nutrients; diminishes the ability of the tissue to properly function. One of the most type of common lung cancers is Adenocarcinoma, which make up to forty percent of these cases. Smoking is the primary reason for Americans to be diagnosed with lung cancer, with a cigarette containing more than 4,000 chemicals that have permanent damage to the lungs causing long term effects (Conrad 2016).

Everyone knows cancer is the second leading killer in the United States. As people, we try our best to adapt when we hear a loved one has cancer. The question, “Why?” or “How?” always seems to come across our minds when hearing the diagnosis. Learning these common causes and risk factors may reduce a person’s chances in getting cancer. The most common mainstream product sold to cause cancer is cigarettes. ”Dangerous chemicals are found in tobacco use such as nicotine, Benzene, and Menthol (wood alcohol). Radioactive materials are in the tobacco leaves used to make cigarettes and cigars. Studies have shown the connection between tobacco products and lung cancer. Did you know? Lung cancer is one of the most preventable diseases that exist.

With more than 1.61 million cases recognized annually lung carcinoma is that the leading cause behind cancer connected loss of life among men and second main cause in the back of loss of life in women worldwide [Jemal et al., 2011]. Morphologically the lung cancer is divided into small cell lung carcinoma (SCLC), non-small cell lung carcinoma (NSCLC) and adenocarcinoma (AC), with non-small cell carcinoma (NSCLC) accounting for 80% of all cases. [Brambilla et al., 2001]. The medical accomplishment in two decades has provided least effect on the treatment of the most cancers, the overall five year survival rate of NSCLC is roughly 15%.

Affecting more than 85% of lung cancer patients, there are more subtypes of non-small cell lung cancer. In non-small cell lung cancer (NSCLC), smoking causes about 90% of the lung cancers diagnosed. The risk mainly depends on how often and how much you smoked. Breathing in secondhand smoke raises the risk for developing lung cancer. Research shows that smoking marijuana may help the cancer cells grow even more. However, there is no direct link between smoking marijuana and developing lung cancer. Being constantly exposed to high levels of air pollution and drinking water that contains a high level of arsenic can increase your risk for lung cancer. Also, a history of radiation therapy to the lungs increases your risk for lung cancer (NLM). Early lung cancer may not show any symptoms, but some are: chest pain, cough that does not go away, coughing up blood, fatigue, shortness of breath, and wheezing. In later stages of NSCLC is: bone pain or tenderness (NLM). 39% of NSCLC occur in the small intestine. Obviously, non-small cell cancer mainly occurs in the digestive system and intestinal tracts of humans

Lung cancer takes the lives of many at a young age and the cause isn’t always clear as of how this disease was contracted. The most popular idea of what causes lung cancer since early times has been using tobacco. Tobacco contains nicotine which is a highly addictive drug that gives a temporary feeling of relaxation. When people get addicted to nicotine, it becomes incredibly difficult for the victims to stop smoking. According to Brody, Lung cancer has been shown to take the lives of more people compared to any other form of cancer and this is the case since lung cancer is associated with life style. New information regarding lung cancer has shown that about one-fourth of those victims who are diagnosed didn’t obtain it through first hand smoking. People can obtain this illness through an “unlucky” combination of genetics (Brody).

The presence of these components in the sputum may cause mutations in the smokers genes, which may lead to the formation to cancerous tumors. The risk of developing lung cancer is directly related to the number of cigarettes smoked (Schaadt, 1992).