Notes On Cystic Fibrosis ( Cf )

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Manuel Alberto Tello Garibay Biology 181 Tuesday/Thursday Cystic Fibrosis Cystic Fibrosis (CF) is a disorder that is passed down from parent to child, which primarily occurs in the Secretory gland, this is the part of the human body that produces mucus. This by all mean does not indicate that the parents are affected, but instead states that they are carriers of this disorder. This is the reason why CF is said to be a recessive trait as oppose to a dominant trait. The main affected areas of the human body by this disorder are the lungs, pancreas, liver, intestines, sinuses, and the female and male reproductive organs according to (Cystic Fibrosis… 2015). When an individual has Cystic Fibrosis the buildup of mucus occurs…show more content…
In addition to this disorder, like any other has certain aspect which define it and make it unique and distinguish it from the rest. For example what genes and chromosomes are linked because of this disorder? As previously stated CF is a recessive disorder, the main gene affected by this occurs in the mutation of the CFTR. The CFTR also known as cystic fibrosis transmembrane conductance regulator. (Cystic Fibrosis… 2015), helps conduct a channel which maneuvers a specific particle know as chloride ion therefore known as the chloride channel. The chloride has the responsibility to help establish a flow of water among tissues where is so happens to be that the formation of mucus is beginning to establish. The CFTR mutation creates a problem among the chloride channel because it prevents the proper flow of chloride ions and water, because of this creating a sticky and thick mucus buildup and as of a result from this the body cannot digest certain substances. The main location of this disorder appears to be on chromosome number 7 on the long arm of q and on band q31.2 (Knight… 2010). This gene is stated to be large since it has the capacity to contain about 180,000 base paired from which 1,480 amino acids are also a part of. The number of mutations associated with this disorder is stated to be 1,500 based on what has been detected on the CFTR protein. This mutation has five levels of mutation based on their
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