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Obstructive Sleep Apnea Study

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Obstructive sleep apnea is associated with cognitive decline and depression. This is the first study explicitly evaluating the impact of obstructive sleep apnea (OSA) on neurocognitive functions and changes in brain morphology in older adults with both depression and cognitive impairment. Under the mentorship of Dr. D.P Devanand, I prospectively screened OSA with the STOP-Bang questionnaire in patients enrolled into the Donepezil Treatment of Cognitive Impairment and Depression (DOTCODE) trial. High and low probability of OSA were defined as a STOP-Bang score of ≥5 (h-OSA) and of <5 (l-OSA), respectively. Baseline magnetic resonance imaging (MRI) was used to evaluate brain morphology. The initial 16 weeks of antidepressant treatment were part

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