Obstructive sleep apnea is associated with cognitive decline and depression. This is the first study explicitly evaluating the impact of obstructive sleep apnea (OSA) on neurocognitive functions and changes in brain morphology in older adults with both depression and cognitive impairment. Under the mentorship of Dr. D.P Devanand, I prospectively screened OSA with the STOP-Bang questionnaire in patients enrolled into the Donepezil Treatment of Cognitive Impairment and Depression (DOTCODE) trial. High and low probability of OSA were defined as a STOP-Bang score of ≥5 (h-OSA) and of <5 (l-OSA), respectively. Baseline magnetic resonance imaging (MRI) was used to evaluate brain morphology. The initial 16 weeks of antidepressant treatment were part
A Sleep Apnea Procedure Could Be The Best Way To Treat Your Condition For Restful Sleep And Improved Health
Obstructive sleep apnea (OSA) is a major health problem, as more than 22 million adults in the U.S suffer from OSA.1 The prevalence of moderate to severe OSA in older adults aged 65 and over is twice as high as that in middle-aged adults.2 Unfortunately, estimates suggest that 85% of individuals with moderate to severe OSA remain undiagnosed.3 Individuals with untreated moderate to severe OSA are at a greater risk for depression (DEP), mild cognitive impairment (MCI), and dementia compared to individuals with no OSA. In OSA, repetitive intracranial blood flow surges during apneic episodes cause disturbances in microvascular functions, resulting in hypoperfusion4-6 and poor cerebral vasomotor reactivity.7-9 Hypoxemia promotes the development of cerebral small vessel disease (C-SVD).10-13 Repeated rapid alternations between hypoxia and reoxygenation cause oxidative stress,14,15 which alters blood-brain barrier functions and leads to the formation of C-SVD.16-18 The consequences of C-SVD are 1) disruption of neuronal activity in regions involved in the regulation of mood and cognition 11,19,20 and 2) reduction of prefrontal and frontal lobe vascular perfusion,10,21-23 which causes neuronal metabolic deficiencies that may lead to synaptic loss and neuronal damage.24,25 The progression of C-SVD is now known to be associated with new-onset depression,26 MCI,27,28 and an increased risk for dementia.27,29,30 Based on this supporting evidence, we hypothesize that C-SVD may mediate
The two most common causes of sleep disorder is central and obstructive sleep apnea. Central sleep apnea is when our breathing is interrupted throughout the night because your brain fails to signal the muscles to breathe. Obstructive sleep apnea occurs with blocked airways and your struggle to breathe triggers coughing or snoring – in actuality your body is grasping for air.
Studies have shown that daytime drowsiness, reduced alertness, and diminished intellectual performance is the result of poor sleep quality and shortened duration of sleep (Badran, Yassin, Fox, Laher, & Ayas, 2015). Moreover, it has been documented that disturbances in sleep and shortened duration of sleep can have negative effects on quality of life (Badran et al., 2015; CDC, 2013). Furthermore, without exception, sleep is vital for the brain and body to relax and repair itself for the purpose of functioning adequately (Jackson, Redline, & Emmons, 2015). Several epidemiologic research studies have linked untreated sleep-disordered breathing to several negative health and safety repercussions, including the increase threat of diabetes, depression,
Obstructive sleep apnea (OSA) is a sleep–breathing disorder characterized by momentary episodes of either complete breathing cessation for periods of ten seconds or more (apnea) or significant reductions in breathing amplitude (hypopnea) caused by a collapsed or obstructed airway; these two conditions can lead to hypoxemia (low levels of oxygen in blood) and hypercapnia (high levels of carbon dioxide in blood). Patients are categorized as having mild, moderate or severe OSA depending on the apnea/hypopnea index (AHI), which is defined as the total numbers of apnea/hypopnea episodes per hour of sleep. In normal individuals the index is usually 5 or lower, 5-15 in mild, 15-30 in moderate and 30 or more in severe OSA patients (1, 2). In patients with mild OSA the oxyhemoglobin saturation drops to 95% and can drop below 80% in severe cases. Obstruction of the airways results in greater breathing effort and fluctuations in intrathoracic pressure, resulting in arousal, sleep interruption and reopening of the airway (3).
Sleep apnea can be a scary and misunderstood problem for many people. The team at Duffield Dentistry can help you get the answers you need to feel safe and secure. Below we have answered some of the questions we most commonly hear regarding sleep apnea and its treatment. If you still have questions or concerns after browsing this page, feel free to contact us. We will be happy to help you or your loved one get the care you need.
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Apnea is frightening for parents as breathing stops suddenly and a baby may become limp and blue. Breathing usually restarts after a few moments and gentle stimulation of a baby, stroking their face or moving them slightly, can encourage a quick recovery unless the child is otherwise ill with pneumonia or heart failure. Before a baby leaves the hospital, discuss with the medical team if you wish to monitor your baby’s breathing with a pulse oximeter or apnea monitor. Monitoring your baby might be a wise precaution and you can request information about resuscitation techniques if your child does not breathe after stimulation. Some parents might choose to complete a CPR course before leaving the hospital.
Thank you very much for referring Neil along for further investigation of likely obstructive sleep apnoea. As you are aware, his wife who I work with at Warringal has been noticing witnessed apnoeas for many years now and has talked Neil into coming along today. Neil in himself sleeps reasonably well and is currently going to bed at around 10.00pm. He will awake between 2.00am and 4.00am and be awake for a short amount of time but will then fall back to sleep until about 7.30am or 8.00am. He wakes reasonably refreshed but of note does have some drowsiness in the afternoon. He will occasionally have an afternoon nap and quite regularly falls asleep on the couch at night. He has been retired for the last 18 months, but prior to that, he
Sleep apnea is a common disorder in which the patient has pauses in breathing or shallow
Sleep apnea is a chronic disorder where breathing repeatedly stops and starts during sleep. It leads to snoring, fatigue and interruptions of oxygen flowing through the body. The need for life insurance varies with age, responsibilities and your health. Life insurance policies become valuable financial resources for maintaining a standard of life. Policies are designed to provide a fixed amount of money according the policy terms and conditions to helping families avoid hardships. Life insurance policies can include the insurer’s ability to draw against the face value of the policy in the event of an illness. In the case of having sleep apnea, the insurer becomes the beneficiary of the policy value. There are also instances, where the policy also functions as a secondary health coverage, should the primarily carrier deny the medical claim.
Obesity is established as one of the leading risk factors for development of both type 2 diabetes and obstructive sleep Apnea(OSA). Obesity is medically defined as a complex disorder involving an excessive amount of body fat. Clearly, this isn’t just a cosmetic concern. The Body Mass Index (BMI) numerical range is 30.0-34.9 is consider obese (1) 35.0-39.9 obese (2), finally 40.0 above is extreme obesity (3). When it comes to Obesity it normally does not have just one underlining issue. Other factors are cardiovascular disease, and hypertension. Most likely a patient will develop a serious sleeping disorder, one called obstructive sleep apnea(OSA). This causes breathing to repeatedly stop and start during sleep. The throat muscles intermittently relax and block the airway during sleeping. Several signs of sleep apnea exist for example; loud snoring, shorter sleeping duration, poor quality of sleep, high blood pressure, morning headaches, decrease libido, weight gain, and even death due to lack of air. Polysomnography is medically performed to evaluate the presence of OSA and its severity.
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is an independent risk factor for depression and cognitive impairment/dementia. Herein we reviewed studies in the literature pertinent to the effects of OSA on the cerebral microvascular and neurovascular systems and present a model to describe the key pathophysiological mechanisms that may underlie the associations, including hypoperfusion, endothelial dysfunction, and neuroinflammation. Intermittent hypoxia plays a critical role in initiating and amplifying these pathological processes. Hypoperfusion and impaired cerebral vasomotor reactivity lead to the development or progression of cerebral small vessel disease (C-SVD). Hypoxemia exacerbates these processes,
This study investigated the positive correlation between obstructive sleep apnea (OSA) with an increased rate of postoperative complications including (1) postoperative hypoxemia, (2) intensive care unit (ICU) transfers, and (3) prolonged length of hospital stay in noncardiac surgical patients. OSA patients commonly express cardiac disease, have an increased risk for postoperative morbidity, and OSA is considered an independent risk factor for patient mortality. This study is significant because there remains a substantial number of patients that arrive for surgery without preceding diagnosis, while there continues to be no standardized diagnostic tool readily available to diagnose OSA within the preoperative area. Kaw et al. demonstrates that there is a increase in many postoperative complications within this at risk patient population.
I remember about a few months ago I had a dream about my second oldest sister boyfriend(Rodrick), he had borrowed my oldest sister(Cindy) car because he had to go somewhere and Cindy lend her car to him. In the dream I was standing in the kitchen n my mom house beside the sink looking through the window that overlooks the back yard in the corner off my eyes I see my sister I thought it was driving down the drive way fast then crashes her car into the tree the door opens that’s when I notice it was Rodrick, my dream ends. I walk into the kitchen and I see my sister there and I tell her what I had dreamed of and she said it was crazy because she was going to let him borrow her car today but he had change his mind. Scientifically I think him crashing