Osteogenesis Imperfecta Essay

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Osteogenesis imperfecta Osteogenesis imperfecta is a group of genetic disorders that mainly affect the bones. The term "osteogenesis imperfecta" means imperfect bone formation. People that suffer from this condition have bones that break or fracture easily; also giving it its more well-known name “brittle bone disease”. These bone fractures often occur from mild trauma or even with no apparent cause. There are eight recognized forms of osteogenesis imperfecta, they range from type I to type VIII. The types can be differentiated by their signs and symptoms, although the main characteristic features overlap between each other. Type I is the mildest form while type II is the most severe form of Osteogenesis imperfecta; the other types of this …show more content…

It is similar to Type IV in terms of frequency of fractures and the degree of skeletal deformity o Large calluses in the largest bones at fracture or surgical procedure sites are the signature of this type o The calluses can also happen randomly

• Type VI:

o Extremely rare. It is moderate in severity and similar in appearance and symptoms to Type IV o Distinguished by a characteristic mineralization defect

• Type VII:

o It is common for leg bones, humerus and femur to be short o Short stature o Recessively Inherited

• Type VIII:

o Similar to Types II or III in appearance and symptoms except for white sclerae o Characterized by severe growth deficiency and extreme under-mineralization of the skeleton o Recessively Inherited

(Types of OI,

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