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Osteopontin Research Paper

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Osteopontin (OPN), an acidic bone-forming protein is widely present in human tissues and is secreted or synthesized by a wide variety of cell types including vascular cells. It has different physiological and pathological functions like cell migration, adhesion, and survival in many cell types [110-111]. This bone-matrix protein is also localized at inflammatory sites [112] to reduce inflammation and is involved in tissue remodeling [113] as well as modulation of VC [114-115] through reducing growth and formation of calcium crystals by binding hydroxyapatite and calcium ions [116]. OPN is also directly associated with conditions of injury and disease like atherosclerotic lesions [115, 117] containing calcium deposits [118] and coronary artery
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