Our research involves creating peptoid coated flat sheet membranes that will hopefully help prove that peptoids can coat artificial lungs to reduce biofouling and potentially prolong the patient’s life. A large healthcare issue in the United States’ is the amount of time people spend on the transplant waiting list before they receive a transplant. Every year, thousands of people are added to the lung transplant waiting list while the rate at which transplants are received has remained constant. The availability of an artificial lung would help to solve this problem. However, exposure to biological fluids leads to biofouling. These effects must be reduced so that the artificial lung can last longer and be more effective. Peptoids have …show more content…
Therefore, we must find a way to prevent biofouling. A potential way of preventing these problems is to create a membrane coated with a material that would prevent bodily substances from attaching to it. As said in the journal by Neda Mahmoudi this type of material is known as a low-fouling material. To be a low-fouling substance, this substance must be hydrophilic and electrically neutral. Being hydrophilic means that the molecule attaches to water molecule more easily rather than rejecting them. This is important because our body is 70% water and we want the substance to interact freely with it. This would help trick the body into thinking that the device is part of the body and not a foreign entity. Being electrically neutral means that peptoids do not have a net positive or negative charge. Having an electrically neutral substance coating a membrane is important because a majority of the body’s cellular processes involve the transfer of ions, and if the material has a net charge, this charge could disrupt these processes. While there might be many types of molecules with these properties, peptoids are the easiest to attach to membranes and are very easy to make in the lab. The journal by Park (2011) explains the unique qualities of peptoids. Peptoids are similar to peptides, which are chains of amino acids. The side chains of peptoids are attached to what is known as the backbone amine
Three paper towels A, B, and C where tested on absorbency. This experiment was tested twice. Paper towel A was 26.5 by 28 centimeters. Paper towel B was 26.5 by 28 centimeters. Paper towel C was 15 by 28 centimeters. Scissors were obtained and each paper towel was cut to 13.5 by 15 centimeters. The weight of the three paper towels at this size was 0.9 grams dry for paper towel A, paper towel B weighed 0.8 grams dry, and paper towel C weighed 1.2 grams. Three beakers weighing 12.2 grams each were obtained. Each beaker was filled with 100ml of water with the outcome of them weighing 128.1 grams each. The weight of each paper towel dry was deducted from the weight of each paper towel. Paper towel A was left to soak for seven seconds.
Protection – 3 different barriers: Chemical Barriers (skin secretion and melanin) Physical/Mechanical Barriers – continuity of the
Healthy and functioning skin barrier is important protector against dehydration, penetration of various microorganisms, allergens, irritants, reactive oxygen species and radiation. The skin barrier may be specifically adjusted to allow penetration. For this reason daily skin care may increase skin regeneration, elasticity, smoothness, and thus temporarily change the skin condition.
When the organs fail the only option is a transplant. With lungs there is only a 50% rate of a five year survival rate after a lung transplantation involving the end-stage respiratory disease. With such a drastic survival rate a study was completed to determine if patients could have a better outcome. This study was done to help determine effective methods to enhance lung transplants before surgery; the Doctors placed the recipients on bi-level positive airway pressure ventilation (BIPAP.) “BIPAP is a noninvasive mode of ventilation administered through a tight-fitting mask to assist spontaneously breathing patients”
When determining which bacteria I wanted to use for this experiment I had to decide on E.coli bacteria which is gram negative and staphylococcus a gram positive bacterium. These were chosen because they are safe enough to grow in a college laboratory and were supplied by the technician. Gram negative bacteria has an outer membrane making it more resistant to antiseptics and antibiotics, it also makes it more fatal to the human host it is inhabiting. Whereas gram
For centuries, genetic diseases have raided the planet growing stronger and mutating faster every day. Scientists have been working hard to develop concoctions to reduce the crippling effects of these diseases; if not eradicate the harsh effects of these potentially deadly genetic conditions altogether. Among these numerous life threatening genetic diseases is cystic fibrosis (CF), an inherited lifelong condition that promotes the production of thick sticky mucus causing lung infections from the entrapment of various bacteria such as Pseudomonas aeruginosa.
blood, skin cells, semen, hair, saliva, and tissue. The use of organic materials, such as
In order to study the transfer of liquid across the plasma membrane, in this experiment a de-mineralized egg was examined. Upon receiving the eggs they had already previously been soaked in a vinegar solution for several days, dissolving the eggs shells thus leaving a thin semi-permeable membrane exposed, which is representative of the cells in our bodies.
Pulmonary Fibrosis is a serious disease that claims and terrorizes thousands of lives and families. Due to severity of the disease two Senators have decided to introduce an Act that is dedicated to this horrifying disease (the Pulmonary Fibrosis Research Enhancement Act (PFREA)). After the onset of symptoms of pulmonary fibrosis, a person has about 5 years of lifespan, that’s taking in consideration treatment that will be given to the patient. About 30 present of patient that receive treatment for pulmonary fibrosis with oral glucocorticoids will see improvement in their lung function. There are many studies that are being to find a cure for the disease or find a way to present it, unfortunately the studies are still on going
The amino acids bond together in bonds called peptide bonds. A chain of amino acids is called a polypeptide chain. The structure in which the amino acids are bonded determines the function of the protein. There are about twenty different amino acids, but there is a wide variety of possible combinations that amino acids can bond, therefore proteins have quite a lot of functions. Some things proteins are used for are the building of the muscles, tendons, organs, glands, nails, and hair. There are many more different functions for proteins. To detect proteins in test materials, there is an identifying agent called Biuret Solution which when mixed with the test material. It turns purple if it contains a protein. The darker the violet color, the more concentrated it is with protein.
They are made up of amino acids (consists of amino group, carboxyl group, hydrogen atom, and R group). Polypeptide bonds form between amino acids to form polypeptide chains. Amino acid sequence is primary protein structure. The secondary structure is the bonding pattern of the amino acids (e.g. helix, sheet, etc.). The tertiary structure consists of the domain, where the sheets or helixes fold on each other and become stable. The quaternary structure consists of several polypeptide chains that form advanced proteins such as human leukocyte
Surfactant is an essential component for the respiratory system to function properly. Knowing the physiology of surfactant in the alveoli is important to know when learning the structure of the air sacs and how they work. This experiment is designed to make the understanding of surfactant in the alveolar film easier to learn, because it's not very simple. Surfactant is a detergent-like substance produced by the Type II alveolar cells in the walls of the alveoli. Surfactant is produced to reduce the surface tension of the water molecules that primarily compose the walls of the alveoli. For this experiment, we will be using milk and food coloring to represent the water (milk) and gas (food coloring) in
Proteins are polymeric chains that are built from monomers called amino acids. All structural and functional properties of proteins derive from the chemical properties of the polypeptide chain. There are four levels of protein structural organization: primary, secondary, tertiary, and quaternary. Primary structure is defined as the linear sequence of amino acids in a polypeptide chain. The secondary structure refers to certain regular geometric figures of the chain. Tertiary structure results from long-range contacts within the chain. The quaternary structure is the organization of protein subunits, or two or more independent polypeptide chains.
Campbell and Farrell define proteins as polymers of amino acids that have been covalently joined through peptide bonds to form amino acid chains (61). A short amino acid chain comprising of thirty amino acids forms a peptide, and a longer chain of amino acids forms a polypeptide or a protein. Each of the amino acids making up a protein, has a fundamental design that comprises of a central carbon or alpha carbon that is bonded to a hydrogen element, an amino grouping, a carboxyl grouping, and a unique side chain or the R-group (Campbell and Farrell 61).
the skin will respond to the chemicals using cloned human tissue cells. The use of egg membrane