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Outline Of Case And Pathophysiology Of Asthma

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Asthma Case Study:
Team Nucleus
Elizabeth Holmes
Alison Husted
Pavithra Jaisankar
Alexandra Keidel
Uma Sankararaman
Violeta Pantaleon
Deirdre Rogers
Kirsten Ross
The Johns Hopkins University School of Nursing

Principles of Pathophysiology
Dr. Olsen/ Dr. Renda
NR 110.312
October 9, 2014

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I. Overview of Case and Pathophysiology Pathogenesis
Asthma is a chronic inflammatory disorder of the bronchial mucosa and hyperreactive bronchial tubes. Its etiology has been linked to both genetic and environmental factors. Several genes, including those that influence the production of proteins and cells involved in the immune response (such as interleukins, eosinophils, mast cells) have been linked with asthma. A decreased number of T-regulatory cells is also associated with asthma. Environmental factors linked with asthma include exposure to allergens, urban residence, and smoking (or exposure to secondary smoke). Recurrent respiratory tract viral infections may also contribute to the development of asthma. Decreased exposure to certain infectious organisms during early childhood, and the consequent underdevelopment of the immune response, can also lead to the development of asthma--this is known as the hygiene hypothesis (McCance & Huether, 2014, p. 1263-4).
The innate and adaptive immune response start with exposure to an antigen in the epithelium of

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