Pathophysiology Of Multiple Sclerosis ( Ms )

Multiple sclerosis, also known as MS, is one of humankind’s most mysterious diseases. No one knows the exact cause and there is no exact treatment. Still multiple sclerosis has the ability to affect nearly 3 million people worldwide and at least 500,000 people in the United States (Boroch). This disease tends to be more common in individuals of northern European descent and women are more than twice as likely to develop multiple sclerosis as men. Of those 3 million people, most of them are between the ages of 20 and 50 years old (Dangond). Even though multiple sclerosis is a mystery disease, scientists are working to determine the exact cause and treatment.

Nearly 400,000 individuals in the United States are diagnosed with multiple sclerosis (MS). Multiple sclerosis is defined as “a potentially disabling disease of the brain and spinal cord”. (Multiple) Multiple sclerosis is classified as an autoimmune disorder in which the immune system attacks an element of itself, specifically the protective sheath (myelin) that covers nerve fibers and causes problems with communication between the elements of the central nervous system and the rest of the body. Multiple sclerosis can cause nerves to deteriorate over time or permanently damaging the nerves, which causes permanent damage to the body as nerves are unable

Multiple Sclerosis (MS) is a neurologic disease that affects the Central Nervous System (CNS) through cellular immune response and the demyelination of CNS white matter (McCance et al., 2014, pp. 630–633). The initial causes of MS are unknown however, it is believed that it could possibly be due to an immune response to an initiating infection or an autoimmune response to CNS antigens on the myelin itself (Brück, 2005) (Miljković and Spasojević, 2013). MS is a result of the degradation of the myelin sheath surrounding neurons and therefore disrupts the transmission of action potentials along these cells. MS can display itself in the form of symptoms ranging from muscle weakness to trouble with sensation and coordination (NHS, 2016). The degradation of myelin leads the body to attempt to remyelinate the neurons, a process that in turn leads to the thickening of the cell by glial cells and this causes lesions to form (Chari, 2007). It is this thickening (sclerae) from which the disease gets its name. Sufferers of MS can either have a relapsing type of MS, in which there are episodes that lead to the worsening of symptoms for a period of time, or a progressive type of MS where symptoms gradually progress and worsen (McCance et al., 2014, pp. 630–633).

Multiple sclerosis is a chronic, progressive neurological disease affecting all aspects of life: physical, cognitive, emotional, and social (Abma). It is known as an autoimmune disease, Where the body’s immune system turns against the body and destroys the protective covering that surrounds nerve cells. This damage to the nerve cells causes many problems for the patient including weakness, muscle stiffness, poor coordination and balance, tingling, numbness, tremors, blurred vision, slurred speech, and memory and concentration problems (Bren)

Multiple sclerosis, or MS, is a disease of the central nervous system. The central nervous system is made up of the brain and spinal cord. Both have nerve fibers that are wrapped in a myelin sheath. In MS, the myelin sheath becomes inflamed and gradually is destroyed. With the destruction of the myelin sheath comes an array of symptoms that may include numbness or tingling, balance problems, weakness, muscle spasms, and blurred vision.

Multiple Sclerosis is a disease that attacks the myelin coating over the nerve receptors in your brain and spinal cord. Myelin is a fatty material that coats and protects the nerves in your brain. These nerves send signals to the rest of your body enabling

Multiple Sclerosis, commonly known as MS is an autoimmune disease of the central nervous system. Scientists have been studying MS since the 19th century. In MS, the body’s immune system produces cells and antibodies that attack myelin in your brain which is essential for the nerves in your brain and spinal cord to conduct electricity to perform its function. The attack on myelin results in vison loss, paralysis, numbness, muscle weakness, difficulty walking, stiffness, spasms, and bladder and bowel problems. MS has varying degrees of severity and affects people between the ages of 20-50, mostly women. Although there are treatments, there is no cause and cure yet.

“Multiple sclerosis (MS) is a disease in which your immune system attacks the protective sheath (myelin) that covers your nerves” (Mayo Clinic). The immune system is a defensive system that protects your body from diseases and illnesses such as parasites and bacteria (Science Museum). Not only does your immune system defend the human body but also the immune system can work against the body, which is known as autoimmune disease. Since the immune system is working against your body to attack the myelin, this creates an opportunity for multiple sclerosis to invade the nerves in the central nervous system (CNS). The myelin within the body acts like insulation to protect and coat the nervous system (National Multiple Sclerosis Society). Once the myelin is eroded, the nerves become exposed which then causes signals to and from the brain to become distorted or irrupted causing a wide range of symptoms to occur (National Multiple Sclerosis Society). The effect of the myelin eroding is an irreversible process (Mayo Clinic). “The damaged myelin forms scar tissue (sclerosis), which

Multiple sclerosis, also known as MS, is an autoimmune and inflammatory disease that is very painful for both the patient and care giver. In the disease, there is inflammation and neurodegeneration acting at the same time. There is currently no known primary cause of multiple sclerosis. The disease is however characterized by damaged fatty myelin sheaths around the axons of the brain and the spinal cord. Myelin is a mixture of proteins and phospholipids that protects many nerve fibers enabling speed at which impulses are conducted. It is pathologically characterized as the presence of glial scars all over in the central nervous system. The disease was discovered by the French neurologist Jean-Martin Charcot in 1868 when he examined the brain

Multiple sclerosis, commonly known as MS, is an auto-immune disease. An auto-immune disease is one in which the body attacks itself. In this particular disease, the central nervous system is being attacked. Specifically, the myelin sheath, or the fatty substance that coats and protects nerve fibers in the brain and spinal cord, is attacked. The attacks cause scar tissue, which makes it difficult for signals to travel between the brain and body. Eventually, the nerves may deteriorate, which is a process that is completely irreversible [5]. See the figure below for more detail.

Multiple Sclerosis is an autoimmune disorder which is characterized by multiple areas of scarring to nerve fibers of the CNS. It often affects people between 20 to 40 years. Currently there are about 1.1 million people suffering from multiple sclerosis. Like most of the autoimmune diseases females are more affected than males in this disease. Multiple Sclerosis effects the central nervous system (brain and spinal cord). The disease commences with a discrete attack known as CIS (clinically isolated syndrome), which may attack any area of the CNS but mostly attacks either the brain stem, optic nerve or spinal cord.

Multiple sclerosis (MS) is autoimmune, inflammatory disease involving the central nervous system (CNS). This disease is a result of the immune system attacking myelin proteins. Usually affecting younger people between the ages of 20 and 50 years, multiple sclerosis slowly destroys the myelin sheath that are located in the CNS causing them to eventually create scleroses, or hardened lesions. Symptoms of multiple sclerosis can be different, but visual, sensory, and motor signs are usually affected with this disease. Some early symptoms care problems like blurred or double vision, numbness, loss of balance, and weakness in arms or legs, as well as fatigue, muscle spasms, speech problems. Approximately 400,000 people in the United States and 2.5 million people worldwide are affected by multiple sclerosis (Hersh and Fox, 2014). Educating ones self about multiple sclerosis is important because it has many unanswered questions. There are many theories and treatments that may seem like they work, but there is no cure or definite reason why MS happens. Multiple sclerosis is also a disease that affects many people and is very hard to treat.

Multiple Sclerosis, also known as “MS” is a chronic condition where the immune system begins to destroy the myelin sheath that covers the nerves in the body and affects the brain and spinal cord (Mayo Clinic Staff, 2014). The myelin sheath is used for protection of the nerves in which these nerves aid to transport nerve impulses all over the body (Ruto, 2013). Once the body’s immune system attacks the myelin sheath, it begins to disintegrate which affects the conductivity of the nerve impulse and impedes the message transmission from the brain to the rest of the body (Ruto, 2013). In turn, the impulses are changed which results in problems in the muscle such as weakness, imbalance and spasms and the body could end up

Multiple sclerosis (MS) is a chronic, often disabling disorder, affecting the central nervous system. The symptoms of MS may be mild, such as numbness in the limbs, or severe, such as paralysis or loss of vision. The progress of symptoms and their severity are currently unpredictable and vary from individual to individual. To date, the new treatments available and the progress of science are giving new hope to people affected by this First you need to specify the characteristics of this disease. In multiple sclerosis we are witnessing an immune system attack against the central nervous system.

Multiple Sclerosis (MS), is considered to be "a immune-mediated disease" (nationalmssociety.org). This means within the Central Nervous System (CNS), the immune system mistakenly attacks myelin – The "fatty substance that surrounds and insulates the nerve fibers" (nationalmssociety.org) – as well as nerve fibers themselves. When the myelin and nerve fibers are damaged, the myelin interferes with nerve conduction. The symptoms of MS relate to this interruption of signaling between