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Pertussis: Whooping Cough

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Pertussis, or more commonly known as ‘whooping cough’ is a highly contagious disease that is caused by a gram-negative coccobacillus bacterium Bordetella pertussis. Pertussis is an infection of the lining of the respiratory tract. This infection creates breathing difficulties, and in children it is often accompanied by a ‘whoop’ sound as the individual tries to inhale.
Features of B. pertussis and its laboratory identification
Pertussis is a reemerging disease whose number of incidences have significantly increased in the past 30 years, even in populations of people who have been vaccinated against the infection. (Van der Zee, A et al. 2015). The infection causes a severe respiratory infection that may become fatal, especially in young …show more content…

(Wood,
N. & McIntyre, P. 2008). Improving vaccines would not only help to reduce incidence rates but also reduce the necessity of comprehensive diagnostic testing.
Transmission of B. pertussis, incidence of disease and its clinical presentation
B. pertussis is a bacterium that infects the respiratory tract and is transmitted through small respiratory droplets that become airborne when an infected individual (both symptomatic and asymptomatic) coughs or sneezes (Trainor, E.A et al. 2015). Once infected, the incubation period for B. pertussis ranges from 4–21 days prior to presentation of clinical symptoms.
Pertussis is clinically classified into different stages: catarrhal, paroxysmal and convalescent
(Wang, K et al. 2014). Symptoms that are presented in the early stage of pertussis, catarrhal, are typically associated with the common cold: rhinorrhea, non-productive cough, and a low- grade fever. The severity of symptoms is typically dependent on the patient’s age. In infants, the symptoms in the paroxysmal stage involve paroxysmal coughing episodes and may be followed by post-tussive vomiting and apnea. Cyanosis can also be observed during …show more content…

Currently there are two types of vaccines available, dTPA (adolescent or adult formulation) pertussis vaccines, which contain smaller amounts of diphtheria toxoid and pertussis agents, and acellular vaccine
(Paediatric formulation) also known as DTPa that consist of selected components of the organism (WHO, 2010). Preventing severe pertussis in infants has been increasingly successful due to programmes using high standard pertussis vaccine to immunize infants
(WHO, 2010). Efficiency of DTPa vaccines that consist of three or more antigens have been described as 71-78% efficient in preventing milder symptoms of whooping cough and 84% for protection against severe disease (The Australian Immunisation Handbook, 2017).
Immunity however, appears to decline over time. The follow up of adults two years after being vaccinated with dTpa have shown a rapid decline in levels of pertussis antibodies.
Studies in older children have also shown a similar decline in vaccine effectiveness even prior to receiving the adolescent booster dose. The future of vaccination for B. pertussis relies on a vaccine that effectively reduces transmission and disease, which is an important

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