I. Overall Lung Function and Organization The human lung is a series of blind end tubes, hollow tubes that that allow for the conduction of air. The conduction of air starts from the nasal cavity or oral cavity, continues to flow through the trachea and bronchus and finally reaches the bronchioles that lead into the alveolus that allows for gas exchange to occur (Phalen et al. 1983). This system can be broken down into two different region; a conducting region and a region of gas exchange. The conduction portion of the respiratory system begins in the nasal cavity and the oral cavity and continues to the bronchioles. The transition from the bronchioles to the alveolar duct results in the transition from the conducting region of the respiratory …show more content…
A large fraction of the phosphatidylcholine components of surfactant is Dipalmitoylphosphatidylcholine, which account for 70-80% of the surfactant lipid layer (Holm et al. 1996). Holm et al. determined that Dipalmitoylphosphatidylcholine is a disaturated phospholipid that has a liquid crystal transition temperature of 41* C - 42*C and exists in a rigid gel phase at body temperature which decrease lung surface tension during expiration and compression of the alveoli. Dipalmitoylphosphatidylcholine is an extensive Phosphatidylglycerol is the second most abundant phospholipid present in surfactant, but along with cholesterol only account for 10 to 15 percent of the phospholipid components(Holm et al. 1996). Lipid synthesis of phosphatidycholine and phosphatidyl glycerol occurs at 24 week of fetal gestation. Alveolar epithiulium continues to develop and differentiate and increase production of surfactant lipid and proteins in order to allow for immediate reduciton in alveolar surface tension at the air-liquid interface. Full functionality of surfactant proteins and associated lipid components arises at 34 to 36 weeks of gestation. (Cite …show more content…
De novo synthesis of surfactant phospholipids are dependent on the amount of fatty acids available in circulation. During fetal development, the type II alveolar cells use intracellular stores of glycerol-3-phosphate for lipid synthesis. Type II Alveolar cells in the postpartum lung need to synthesize lipids and proteins to establish the reduction in surface tension needed to maintain a proper liquid-air barrier(Ridsdale et al. 2004). Glycogen appears to be the main source of carbons needed to develop the glycerol backbone within surfactant lipids. Ridsdale et al. (2004) states the metabolic demands required of type II alveolar cells during close term requires a build up of glycogen which could play the role of an energy source in surfactant lipid synthesis. Lamellar bodies contain Golgi apparatus, Endoplasmic Reticulum(ER), and mitochondria that is necessary for the production of the lipids and protein components of surfactant. The build up of glycogen changes the orientation of the type II alveolar cell organelles. In the presence of the glycogen, the golgi appartus, ER, and mitochondria are surround the glycogen. However glycogen region is where the lamellar bodies are present. Risdale et al. illustrates with Figure 2- C,D and E labeled with arrows pointing to the ER, the mitochondria labeled
RDS is caused by a defective or delayed production of surfactant in structurally immature lungs. Surfactant is a complex mixture of phospholipids and proteins secreted by the type
The presence of fluid in the alveolar space could potentially cause the lung capacity to be effected as well.
Tadpoles, like humans, start developing lungs at a young age. Tadpoles’ lungs start to develop just like humans. Like tadpoles, humans start out by breathing in water and after twenty-three weeks the lungs are fully developed and ready to breathe air. It takes tadpoles around “… 4 weeks for the gills to start getting grown over by skin, until they eventually disappear” (Life Cycle of a Frog, 2015). Since it does not take a tadpole’s lungs as long to develop, scientists are able to use tadpoles to study the effects the different drugs or molecules might have on human lungs while they are developing.
3-7: The cells of the connective tissue pictured below in a cross section from the trachea are specialized for fat storage and do not form ground substance or fibers. On prepared slides, this type tissue appears somewhat like a fish net with white spaces connected together in a network. The cytoplasm and nucleus have been pushed to one side by a single, large, fat-filled
The Respiratory system is an integrated system of organs involved in the intake and exchange of oxygen and carbon dioxide between an organism and the environment. Your Respiratory system is made up of the organs in your body that help you breathe. The Respiratory system is the system of the body that deals with breathing. The trachea is a wind pipe. The trachea is a pipe shaped by rings of cartillage. A Bronchi are two tubes that carry air into the lungs. The Respiratory system consistes of many different organs. The organs are the lungs, trachea, bronchi, alveoli, diaphragm, nose, mouth, and pharynx. In the Respiratory system the right lung is larger and has more lobes that the left lung becuase the heart is normally located on the left side, and takes up space where the lung would had been. The functions of the Respiratory system is to supply the blood with oxygen in order for the blood to deliver oxygen to all parts of the body. The Respiratory system is also used for the of exchange gases. The importance of the Respiratory system is that it allows for the exchange of gases; meaning carbon dioxide and oxygen. These gas exchanges occur in the alveoli's and the capillaries. This gas exchange of gases is the Respiratory system's means of getting oxygen to the blood. The goal of breathing is to
Small air sacks called alveoli are at the tips of the bronchioles. When air reaches them, the oxygen concentration is high, which causes diffusion into red blood cells travelling through pulmonary capillaries (7). The red blood cells then distribute the new oxygen to the rest of the body. When they reach the alveoli again, they exchange carbon dioxide (a form of cell waste) for new oxygen, and repeat the process. The carbon dioxide is moved through the bronchioles, bronchi, and trachea in the form of exhalation.
Another group of patients which require challenging ventilation strategies are the preterm infants. The lungs of preterm infants have undeveloped distal airway structures, with a thick air/blood barrier and a small surface area for gas-exchange (Wallace et al., 2009). They are most likely to be surfactant deficient due to under-developed epithelial cells which lack the type II alveolar cells (Wallace et al., 2009). As a result, preterm infants often require respiratory support in the minutes following birth (Roupie et al., 1995).
In the alveolar walls are cells that secrete a fluid, which keeps the inner surface of the alveoli moist allowing gases to dissolve. This fluid, called a surfactant, in the alveoli also contains also prevents the thin walls of the alveoli from sticking to each other. The moist alveoli allows for efficient gas exchange as it allows the gases to diffuse in solution which is more efficient than just diffusing as a gas.
- The walls of the alveoli are made up of simple squamous epithelial tissue to allow quick diffusion
The respiratory system is the process responsible for the transportation and exchange of gases into and out of the human body. As we breath in, oxygen in the air containing oxygen is drawn into the lungs through a series of air pipes known as the airway and into the lungs. As air is drawn into the lungs and waste gas excreted, it passes through the airway, first through the mouth or nose and through the pharynx, larynx and windpipe – also known as the trachea. At this point it then enters the lungs through the bronchi before finally reaching the air sacs known as alveoli. Within the lungs, through a process known as diffusion, the oxygen is transferred to the blood stream through the alveoli (air ducts) where it is then transported inside
The placenta is a major source of fetal prostaglandins and its removal after birth allows for the lungs to expand and become metabolically active, where most prostaglandins are degraded. This, in combination with increased pulmonary oxygen tension, in healthy full-term infants, normally causes functional closure of the ductus arteriosus within 15 hours after birth.
The most serious of these being hyaline membrane disease (HMD), most commonly known as RDS or respiratory distress syndrome. Babies that suffer from this condition will tend to find it very difficult to breathe due to the increased surface tension and the ultimate lack of oxygen transported through the body can seriously impair and damage the functions of the brain and other organs of the baby. Surfactant deficiency’s can also sometimes be caused by mutations in a particular gene. An example of this is surfactant protein or SP-B deficiency. This particular dysfunction is hereditary and is caused by a gene mutation on chromes number two. Babies that suffer from tis condition rarely survive past a few months. However there are some procedures that can help babies who may have been born prematurely and have not manufactured enough surfactants to support regular functions. Surfactant replacement therapy and surfactant supplements are amongst the most popular treatments of these types of surfactant deficiencies in newly born
Preterm infants are born during the late cannalicular to early saccular stages of lung development, which corresponds to the period when respiratory bronchioles capable for gas exchange and type II alveolar
Air enters your lungs through a system of pipes called the bronchi. These pipes start from the bottom of the trachea as the left and right bronchi and branch many times throughout the lungs, until they eventually form little thin-walled air sacs or bubbles, known as the alveoli. The alveoli are where the important work of gas exchange takes place between the air and your blood. Covering each alveolus is a whole network of little blood vessel called capillaries, which are very small branches of the pulmonary arteries. It is important that the air in the alveoli and the blood in the capillaries are very close together, so that oxygen and carbon dioxide can move (or diffuse) between them. So, when you breathe in, air comes down the trachea and through the bronchi into