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Phosphatidylcholine

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I. Overall Lung Function and Organization The human lung is a series of blind end tubes, hollow tubes that that allow for the conduction of air. The conduction of air starts from the nasal cavity or oral cavity, continues to flow through the trachea and bronchus and finally reaches the bronchioles that lead into the alveolus that allows for gas exchange to occur (Phalen et al. 1983). This system can be broken down into two different region; a conducting region and a region of gas exchange. The conduction portion of the respiratory system begins in the nasal cavity and the oral cavity and continues to the bronchioles. The transition from the bronchioles to the alveolar duct results in the transition from the conducting region of the respiratory …show more content…

A large fraction of the phosphatidylcholine components of surfactant is Dipalmitoylphosphatidylcholine, which account for 70-80% of the surfactant lipid layer (Holm et al. 1996). Holm et al. determined that Dipalmitoylphosphatidylcholine is a disaturated phospholipid that has a liquid crystal transition temperature of 41* C - 42*C and exists in a rigid gel phase at body temperature which decrease lung surface tension during expiration and compression of the alveoli. Dipalmitoylphosphatidylcholine is an extensive Phosphatidylglycerol is the second most abundant phospholipid present in surfactant, but along with cholesterol only account for 10 to 15 percent of the phospholipid components(Holm et al. 1996). Lipid synthesis of phosphatidycholine and phosphatidyl glycerol occurs at 24 week of fetal gestation. Alveolar epithiulium continues to develop and differentiate and increase production of surfactant lipid and proteins in order to allow for immediate reduciton in alveolar surface tension at the air-liquid interface. Full functionality of surfactant proteins and associated lipid components arises at 34 to 36 weeks of gestation. (Cite …show more content…

De novo synthesis of surfactant phospholipids are dependent on the amount of fatty acids available in circulation. During fetal development, the type II alveolar cells use intracellular stores of glycerol-3-phosphate for lipid synthesis. Type II Alveolar cells in the postpartum lung need to synthesize lipids and proteins to establish the reduction in surface tension needed to maintain a proper liquid-air barrier(Ridsdale et al. 2004). Glycogen appears to be the main source of carbons needed to develop the glycerol backbone within surfactant lipids. Ridsdale et al. (2004) states the metabolic demands required of type II alveolar cells during close term requires a build up of glycogen which could play the role of an energy source in surfactant lipid synthesis. Lamellar bodies contain Golgi apparatus, Endoplasmic Reticulum(ER), and mitochondria that is necessary for the production of the lipids and protein components of surfactant. The build up of glycogen changes the orientation of the type II alveolar cell organelles. In the presence of the glycogen, the golgi appartus, ER, and mitochondria are surround the glycogen. However glycogen region is where the lamellar bodies are present. Risdale et al. illustrates with Figure 2- C,D and E labeled with arrows pointing to the ER, the mitochondria labeled

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