Background
Chest pain is a common presenting complaint to the emergency department of any hospital and, given that ischemic heart disease is considered the world 's biggest killer1, it is imperative to investigate such patients at length to exclude coronary artery disease (CAD). Physicians commonly rely on the measurement of cardiac biomarkers such as creatine kinase (CK) and its isoenzymes for such a differential diagnosis. Despite the determination of Troponin levels in the evaluation of myocardial ischemia, an elevated CK-MB can provide diagnostic uncertainty as it rises earlier than troponin in myocardial injury. Thus, it is important to remember the other causes of an elevated CK, and by extension it isoenzymes when investigating such
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These are known as macro-enzymes and carry a molecular weight of greater than 200 kDa3,4. Macro molecular forms of not only creatine kinase have been described but also that of lactate dehydrogenase, amylase and aspartate aminotransferase6. These molecules provide diagnostic challenges for physicians as they often lead to an interference in the biochemical assay for their respective enzymes, resulting in false positive diagnosis such as acute myocardial ischemia or even acute pancreatitis.
This discussion will focus on the macro-molecular forms of creatine kinase: macro-CK type 1 and macro-CK type 2. Macro-CK type 1 is a complex formed by one of the CK isoenzymes and immunoglobulin in an antigen - (auto) antibody reaction7. Most often, it 's components entail CK-BB and monoclonal IgG3. Its prevalence is estimated at 0.9-1.2% 3. Albeit, very rare, researchers have shown its association with various disorders including hypothyroidism, neoplasia, autoimmune conditions, myositis and cardiovascular disease8. Persuasively, Lee et al (1994) showed that more than 50% of his patients with macro CK type 1 had some form of myositis, whether it was autoimmune, malignancy associated or drug induced (PBrien, J.The Macroenzymes: A Clinical Review. Mayo Clinic Proceedings. 1993; 68(4):349-354.
7. Stein, W., Bohner, J., Krais, J.,
To determine if the patient’s chest pain is related to injury, you would look for ST-segment elevation. Myocardial injury represents a worsening stage of ischemia. If ST-segment elevation is greater than or equal to 1mm above the isoelectric line, it is significant and treatment needs to be prompt and effective to try to restore oxygen to the myocardium, and to avoid or limit infarction. The absence of serum cardiac markers confirms that infarction has not
It is found in skeletal muscles. Creatine phosphate can house high-energy phosphate bonds. There is an abundance of ATP while the muscle cell is at rest. The creatine kinase transfers the high-energy phosphate bonds of the ATP to the high-energy phosphate bonds of the creatine phosphate. Once the cell is ready to contract, creatine kinase removes the phosphate groups from creatine phosphate and transfers them to ADP to create ATP. ATP is used to drive the contraction since it is a quick energy source. A large amount of creatine kinase should not be present in the bloodstream unless there is a large-scale destruction of muscle cells. The Duchenne muscular dystrophy causes this phenomenon to occur where muscle cell membranes are destroyed spilling out the creatine kinase into the bloodstream.
African American male that is seen today for followup post hospital discharge. He is a 48-year-old gentleman with complicated cardiac history as well as neurological history including congestive heart failure. History of strokes 01/2017, possible sick sinus syndrome. He has an implanted pacemaker that was placed in 06/2017, as well as hypertension. He was taken to the Central Hospital on 09/01 with presentation of chest pain, noted to be around his pacemaker site. He identified being in seizure and suddenly felt chest pain with shortness of breath, and was offered nitro, he developed headaches and dyspnea post nitro treatment, of note is that the EKG that was obtained during that process, did not identify any pacemaker spike despite having a
3. What is the most common pathophysiologic precipitating event for ACS? What differentiates USA from MI?
In a normal human being the heart correctly functions by the blood first entering through the right atrium from the superior and inferior vena cava. This blood flow continues through the right atrioventricular valve into the right ventricle. The right ventricle contracts forcing the pulmonary valve to open leading blood flow through the pulmonary valve and into the pulmonary trunk. Blood is then distributed from the right and left pulmonary arteries to the lungs, where carbon dioxide is unloaded and oxygen is loaded into the blood. The blood is returned from the lungs to the left
In the novel, No Apparent Distress: A Doctor’s Coming-of-Age on the Front Lines of American Medicine by Dr. Rachel Pearson, the author, Dr. Pearson, encounters several patients and experiences several personal challenges that builds her role as a doctor and helps her realize the social injustices in the healthcare system. With the personal encounters she faces with her patients, her family and her peers, Dr. Pearson learns that there are several flaws in the healthcare system that is beyond the doctor’s power to fix. She also learns that the education she receives progressively builds as she meets new patients and learns about their individual cases. She begins to understand that the nature of her education is surprising because one cannot fully understand something unless they have experienced it. Consequently, Dr.
Noyan, T., Gozlukaya, O., & Cankaya, S. (2013). The Evaluation of Cardiac TroponinI Assays Measured Radiometer AQT90 Flex and ReLIA Analyze
Chest pain is posed as life threatening-has many definitions ranging from either stabbing, dull, crushing or burning. In certain cases, pain travels up the neck, the jaw, can radiate to the back or down one or both arms. Many different problems can cause chest pain and it can be difficult to determine the exact cause of chest pain (Burman et al’, 2011). Patients’ experiencing chest pain is symptoms consistent with, myocardial ischemia and is a common reason for presenting to ED (Pub Med Central, 2010).
The EKG is read by a doctor or specialist, such as an internist, family medicine doctor, electrophysiologist, cardiologist, anesthesiologist, or surgeon. The doctor will look at the pattern of spikes and dips on your EKG to check the electrical activity in different parts of your heart. The spikes and dips are grouped into different sections that show how your heart is working
The case I chose was published in The Baltimore Sun. The title of the article is, Prosecutors: No Charges against Baltimore officer who used Taser on teen. This article is about a 19 year-old teen named George Vonn King Jr. who died from cardiac arrest. The article states that Mr. King was tased several times by police, before going into cardiac arrest (George). This incident took place at the “MedStar Good Samaritan hospital” in Baltimore MD, where Mr. King was admitted as a patient. Mr. King suffered from Meningitis which causes seizures, along with aggressive behavior. When King was asked by hospital staff to move to the intensive care unit, he became aggressive, which may have been because of the medication he received (George). Hospital
Chest pain is a frequent cause of emergency department presentation. Many times, chest pain can be an indicator of myocardial infarction. Yearly, about 600,000 people die of heart disease in the United States, with a total of about 700,000 having a myocardial infarction. The leading source of death for both men and women is heart disease ("Heart disease facts," 2014). Managing the challenging clinical problems of those presenting with chest pain can be demanding. While clinical judgment is imperative in managing these patients, rapid treatment protocols to evaluate risk
Objective The objective of this experiment is to study the effect of varying temperatures on the enzyme catalase by measuring the oxygen production as it breaks down hydrogen peroxide. Introduction Enzymes are used in our daily lives in many ways. From industry to agriculture, enzymes play a necessary role in everything from bread to laundry soap.
With attention to her heart issues, I checked her capillary refill on both fingers and toes for perfusion, her pulse (62 bpm) and her blood pressure (120/58). Additionally, when she was getting up I had her sit for a minute before standing to decrease the likelihood of orthostatic hypotension.
Various contributing mechanisms have been identified, including the negative inotropic effects of different circulating factors, especially cytokines (TNFα, IL-1β and IL-6), lysozyme c and endothelin-1, disturbances of intracellular calcium trafficking within cardiac myocytes, alterations of myocardial microvascular blood flow, mitochondrial abnormalities and autonomic dysfunction [71-73]. There are various effects which may be responsible for the toxic actions of peroxynitrite on the heart, including myocardial cell death, either by caspase-3-dependent apoptosis [74], or PARP mediated necrosis [75]. A direct correlation linking the degree of myocardial PARP activation and the severity of cardiac functional alterations has been established in humans with septic shock [76]. Myocardial contractility can also be impaired by peroxynitrite due to disturbance in regulatory mechanism of intracellular calcium through the inactivation of SERCA2A [77], by altering different myofibrillar proteins including actin, myosin [78] and alpha-actinin [79], by interrupting myofibrillar energetics through inactivation of the myofibrillar isoform of creatine kinase [80] and by activating matrix metalloproteinases [81], which promotes contractile failure by cleaving key sarcomeric proteins including troponin and myosin light chain
Blood tests will be done to assess troponin I, troponin T, creatine kinase (CK) and myoglobin which are classified as cardiac serum markers (Cardiac Emergencies, n.d.).