3.6 Community detection Figure 9. Community detection on the drug side-effect network using walktrap community detection algorithm. There were 61 communities detected in the network with the largest community consists of 35 drugs and smallest ones consist of only two drugs.
As a result of using walktrap community detection algorithm, there were 61 communities detected altogether. The biggest community consists of 35 drugs and the smallest ones consist of two drugs.
4 Discussion
4.1 Improvement in Shiny GUI
Due to my limited skills and experience in programming, Shiny GUI was not yet completed according to original plan. A lot of improvements and additions can be made on the existing coding. For future studies that would like to
…show more content…
4.3 Network analysis
In the results section, five drugs with highest centrality value and five drugs with lowest centrality value were presented in tables with the corresponding first-level ATC code. However, all three centrality measures (degree, betweenness, and closeness) did not show a fixed pattern. Drugs that acquire high centrality value do not necessarily be identified with top seven ATC code (N, C, J, S, D, A, R) and vice versa, except for ATC code for drugs with the highest five closeness centrality value happened to be in the top group. This could suggest there is possibility of drug interactions from various therapeutic classes.
From Figure 7, majority of drugs lie on the left side of distribution, i.e. low degrees, and this could imply that drug interactions were likely to be evenly distributed in the drug side-effect network. Justification of this matter can be inferred from the network itself, where there was one massive component with 356 drugs (out of 424 drugs). Drugs with the highest and lowest degree are carteolol and ginkgo respectively. Therefore, in the region with a lot of overlapping nodes in Figure 5, carteolol is difficult to be spotted due to high number of adjacent edges connected to it. For ginkgo, it possesses a low degree centrality value since ginkgo is connected only to hydroxychloroquine by Group 2 interaction (i.e. drugs with similar structures or targets).
Since methadone has the
Medication has also become increasingly complex. There has been a massive increase in the number and variety of medications available. In addition, many medications have different routes of delivery, variable actions (long acting, short
breakdown of drugd within the body and the characteristic interactions of a drug in terms of its
Pharmacology made easy was the third required ATI assignment. ATI defined the word pharmacology as the study of drugs and their effect on the human body. A medicine’s therapeutic effect is stated to be it’s good outcome and the side effects are the negative results from it. There are twelve drug categories divided according to the human’s body system. These are neurological, musculoskeletal, respiratory, endocrine, pain/inflammation, cardiovascular, hematologic, gastrointestinal, reproductive and urinary, and the immune drug category. Medicines in the same category may share the same therapeutic and side effects. Additionally to the above information, this unit explained that there are trade and generic names of drugs. Trade name is the commercial
All medications are distinctive. A few medications are seen as social medications. Different medications can make a man higher than the snow-topped tops of the Himalayas. On the whole, medications are expanding in notoriety. Unlike a quarter century ago, there are more drug users in the world today.
Prescription medication is an important part of healthcare and a must have for patients because it helps manage a lot of symptoms and diseases. It can help kill bacteria causing patients to feel ill, it can also reduce pain and suffering for others. However, most mediations have some type of adverse side effects as it is made from chemicals processes or extracts from herbal plants. There are contraindications and cautions to every medication in which we have to be aware of when prescribing the medication; there is also drug to drug interactions that may occur. To help prevent medication errors we can use online resources to look for any drug to drug interactions and contraindication/adverse effects. We also need to stress the importance
Ng, Rick. Drugs: From Discovery to Approval. 3rd ed. Hoboken, NJ: John Wiley & Sons, 2015.
But on the contrary, based on limited evidence of case control studies, the author of pharmacokinetic drug interactions profile of PPIs stated that omeprazole has a considerable potential for drug interaction than Lansoprazole5. This claim is based on the fact that omeprazole has been available longer than other PPIs5 such as Lansoprazole. This is also consistent with the pharmacological study done on Lansoprazole, which concluded that the properties of Lansoprazole differ greatly from Omeprazole with respect to their pharmacological properties and chemical structures8. For example, Lansoprazole acquires a trifluoroethoxy group8 as a result of the addition of fluorine, which appears to improve its pharmacological activity than to Omeprazole. Therefore, since omeprazole is first discovery of PPIs is considered to have more drug interactions, after refining its properties lead to the discovery of Lansoprazole acquires a better pharmacological
Communities are all about groups of individuals who share something in common. This makes going on the internet seem like an odd way to find more communities, form new ones, or strengthen pre-existing ones. The internet however is full of communities. Communities can be based upon religion, location, ethnicity, an interest, or a personal matter. The internet itself is “a global distributed data communications network” (Kirmayer, Raikhel, & Rahimi, 2013, p. 166). This is what makes the internet so full of communities because communication is the key to putting multiple individuals with commonalities into communication, which is the basis of any community. Online communities differ from communities that exists off the web in a couple of
Bryant, B., & Knights, K. (2014). Pharmacology for Health Professionals (4th ed.). Chatswood, NSW: Elsevier Health Sciences.
In the world today there are hundreds of thousands of different kinds of medications. For many, the sheer number can be overwhelming, and categorizing them can be even more so. However, drugs can be sorted into 3 categories based on their uses. The 3 types of medications are drugs used for mental health, physical health, and those drugs that are used illegally. In this case, I will not be considering the abuse of prescription drugs, because, although illegal, they were originally used to improve mental or physical health.
Figure 4.1 describes the distribution of the primary targets of drugs in the BNF, with human targets being the highest at 71%, followed by non-human targets at 17%, and non-specific targets at 12%. Analysis of the molecular target distribution of drugs with known human targets in the BNF reveals that receptors make up the highest group of drug targets, as shown in Figure 4.2. 59% of the human drug targets are receptors, and 33% of these are GPCRs. Enzymes are the second largest group of molecular targets in the human genome, making up 22% of all human drug targets.
Thus, by combining my passions of biochemistry and serving others, I know that I can make the most change as a pharmaceutical researcher. The chemistry and biochemistry behind the body and medicine has always fascinated me. The complexities of every medication or vitamin in combination with any health defect serves as a puzzle too interesting to leave unsolved. I realize these changes that need to be made fall under a political scope more than the microscope of biochemistry. However, I think that by approaching the development of these drugs with the idea of lower prices in mind will make an unfathomable difference in so many
Pharmaceutical sciences combine a broad range of scientific rules that are critical to the discovery and development of new therapies and drugs, and so in that saying, knowing this kind of information can help people around the world greatly in the future.
Drug research is connected to a range of academic studies such as biology, pharmacology, medicinal chemistry and toxicology. Pharmaceutical researchers can design novel therapeutic drugs based on these studies above. The invention of new drug can be divided by function into two stages: drug discovery and drug development. Drug discovery is the process by which a new drug candidate is found and identified. Distinctively, bringing a new drug candidate to the market through clinical trials is called drug development. The first part of this essay provides an overview of drug discovery and pre-clinical research and development
ISSN: 2277- 7695 TPI 2014; 3(7): 08-12 © 2013 TPI www.thepharmajournal.com Received: 14-08-2014 Accepted: 28-08-2014 Rizwan Raheem Ahmed Professor, Department of Business Administration & Commerce Indus University, Pakistan