Presence Of Increased Stiffness Of The Common Carotid Artery And Endothelial Dysfunction

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Study Design: Case-Control Study
Title: Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: A prospective study
Journal: The Lancet
Numerous epidemiological studies infer that cardiovascular complications have a directly proportional relationship with obesity in children. The study I chose however, has gone deeper by observing arterial changes as well as its relationship to cardiovascular risk in children who are obese. One of the reasons this study design was chosen by the author comes from a 55-year cohort study which evaluated the morbidity and mortality from cardiovascular diseases in adults who were overweight in their adolescent years. The study showed that of the adults evaluated, the adults with obesity in their adolescent years had an increased risk of morbidity and mortality from cardio vascular disease, regardless of their weight classification as an adult. What these studies did not observe however, were the pathological changes that take place in the cardiovascular system, and even more specifically how obesity-associated artherogenesis develops during the adolescent years. Fortunately, with the development of new technology, different echo tracking procedures could be used to observe the pathological function of the carotid and brachial arteries and children. These new echo tracking techniques are noninvasive and can be used to determine if overweight children show early pathological
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