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RTX Response Paper

Decent Essays

We performed a retrospective chart review of clinical data already collected in the process of treatment of pediatric patients at our institution. Records of patients between the ages of 0-18 years who received RTX infusions for a diagnosis of steroid dependent or steroid resistant nephrotic syndrome or glomerulonephritis between August 1, 2009 and December 31, 2012 were reviewed. We collected data on the disease status (like renal histology, duration of nephrotic syndrome, number of relapses) and treatment status (like immunosuppressive treatments used before RTX, number of courses of RTX) of the patients. RTX response was measured at 1, 3, 6, 12, 18 and 24 months post RTX therapy in terms of proteinuria, spot urine protein/creatinine ratio (Up/Uc) or creatinine clearance. Complete blood counts, lipid profile and serum albumin levels were monitored regularly. Rituximab Therapy …show more content…

When treated with more than a single dose, patients were administered one dose per week. To minimize infusion reactions, patients received intravenous methylprednisolone, oral acetaminophen and diphenhydramine 30 min prior to RTX infusions. All patients were closely monitored for at least 24 h after RTX infusion for observation of infusion reactions. Immunosuppressive agents and/or oral prednisolone used at the time of rituximab treatment were continued until clinical response was demonstrated in the form of remission or decreased

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