Rabies Virus Research Paper

The virus fuses with the cell’s plasma membrane. The capsid proteins are removed, releasing the viral proteins and RNA. Reverse transcriptase catalyzes the synthesis of a DNA strand complementary to the viral RNA. Reverse transcriptase catalyzes the synthesis of a second DNA strand complementary to the first. The double-stranded DNA is incorporated as a provirus into the cell’s DNA. Proviral genes are transcribed into RNA molecules, which serve as genomes for the next viral generation and as mRNAs for translation into viral proteins. The viral proteins include capsid proteins and reverse transcriptase (made in the cytosol) and envelope glycoproteins (made in the ER). Vesicles transport the glycoproteins from the ER to the cell’s plasma membrane. Capsids are assembled around viral genomes and reverse transcriptase molecules. New viruses bud off from the host cell.

Some viruses also have an outer bag of lipo-protein called an envelope. After a virus attaches to a living cell, it either enters the cell to release the genetic information, or, the virus injects the information through the cells outer lining. Thus changing the cells natural functions and forcing the cell to spend its energy to create copies of the virus. The cell will go on making copies of the virus until the cell is used up and dies. The virus then leaves the dead cell and invades a nearby cell and the process starts all over. There are five types of human herpes virus: Varicella zoster which causes chickenpox, Epstein Barr virus which causes infectious mononucleosis, cytomegalovirus which can cause cytomegalic inclusion disease in infants, and herpes simplex viruses 1 and 2.

RSV is caused by TLR3 activation. It initiates infections by binding to a cellular receptor and then the viral envelope fuses with the plasma membrane. The virus attaches the cell through the main protein, the G protein and fuses with the plasma membrane of the host cell through the F protein. After penetration, the nucleocapsid of the virus is released into the cytoplasm where replication occurs (3). The viral RNA is like a template for mRNA (3). The mRNA’s job is to translate the viral proteins and complementary RNA serves as a template for virion RNA

Step 1: How will you identify the “vital” cellular protein that the virus targets for degradation? (Hint: think proteomics). (3 pts.)

The battle of Verdun took place in Verdun in Northern France from the 21st of February to the 18th of December 1916. The battle was between the French Army and the German Army. The battle was mainly trench warfare and had a large number of casualties from both sides. The Commanding officer of the section of the German Army that was in france at the time, was “Eric Von Falkenhayn”. His views on the war was that Britain was the strongest of the Allied countries and the war could only be won by taking out their best allies Russia, France and Italy. He decided that taking out france would be the biggest blow on Britain, so they launched an offensive on the French Position on the “Western Front”. The Germans wanted to pick a position which would draw all the french soldiers into one spot to defend, they chose the Fortress of Verdun, because it was in the road of the Main German communication lines.

RSV enters a cell through fusion at the plasma membrane. Initiation emerges when the G protein of the RSV binds to a specific long unbranched polysaccharide of the

* Flaviviruses: share a common size (40-60nm), symmetry (enveloped, icosahedral nucleocapsid), nucleic acid (positive-sense, single stranded RNA approximately 10,000-11,000 bases), and appearance in the electron microscope. Therefore, images of West Nile virus are representative for this group of viruses.

Viruses are microscopic particles that invade and take over both eukaryotic and prokaryotic cells. They consist of two structures, which are the nucleic acid and capsid. The nucleic acid contains all genetic material in the form of DNA or RNA, and is enclosed in the capsid, which is the protein coating that helps the virus attach to and penetrate the host cell. In some cases, certain viruses have a membrane surrounding the capsid, called an envelope. This structure allows viruses to become more stealthy and protected. There are two cycles in which a virus can go into: lytic and lysogenic. The lytic cycle consists of the virus attaching to a cell, injecting its DNA, and creating more viruses, which proceed to destroy the host. On the other hand, the lysogenic cycle includes the virus attaching to the cell, injecting its DNA, which combines with the cell’s DNA in order for it to become provirus. Then, the provirus DNA may eventually switch to the lytic cycle and destroy the host.

When we hear the word virus, we usually think of something that makes us sick. A virus is an ultramicroscopic infectious organism that, having no independent metabolic activity, can replicate only within a cell of another host organism. A virus consists of a core of nucleic acid, either RNA or DNA, surrounded by a coating of antigenic protein and sometimes a lipid layer surrounds it as well. The viral genome provides the genetic code for replication, and the host cell provides the necessary energy and raw materials. To fight viruses, we use vaccines. While some may infect a broad range, other viruses can only infect certain kinds of cells. Vaccines are made of inactive, dead or weakened virus cells or protein antigens that can no longer infect

Muslim immigrants have arrived to the United States of America from every nuke and corner of the sphere. The population is diverse in their own ways but each one of them bears similar reasons: Some desire to escape an old way of life, others to find a new one. Some wanted to escape violence, others the fetters of penury, or simple lack of opportunity. They have arrived with fervent hope, and often nothing more. The initial response received by them was largely varied. These new Americans found a vast new land hungry for their labor. But some, unfamiliar with these newcomers’ customs and religions, treated the new Americans as outsiders and believed they could never be real Americans. And with the events like the Gulf War and the World Trade Center bombing outpoured anti-Islamic sentiments in the 1990s. These sentiments intensified with the heinous and abominable attacks of September 11th. Muslims were being labeled as “extremists”, “jihadists”, “fanatics”, “fundamentalists” etc. They were being feared, discriminated and even harassed.

The protective capsid helps the virus escape detection and destruction during the invasion of the host. When the virus reaches the target cell, biochemical reactions between the capsid and cell wall allow the virus to latch on and inject its genome into the cell’s interior. Once inside, the viral genetic material insinuates itself into the host’s DNA or RNA. In an efficient feat of natural bioengineering, the host cell’s genetic machinery now does the rest of the work for the virus. The cell, which had already been making copies of its own genome, now also replicates that of the virus. Coded within the viral material is the blueprint for making more copies of the viral genome. Further instructions command the production of capsids and directions for assembly of new viruses. After the host cell becomes engorged with viruses, it explodes, sending the new

Sidney Hook said, “Everyone who remembers his own education remembers teachers, not methods and techniques. The teacher is the heart of the educational system.” Mr. Fitzpatrick an experienced teacher and Mr. Meyer a brand new teacher were both influenced by their teachers to help them realize their passion to teach. Mr. Fitzpatrick was my U.S. History teacher my freshman year of high school and I remembered when he taught anyone could tell how much he loved history and how every year he brings joy to so many students by hosting Disco Daze. Disco Daze allows anyone who participates to go back in time for a little while and truly experience what it was like living in the 70s. It was a truly memorable experience as a student and I still look forward to it as a senior. Mr. Meyer reaches out to students through his coaching. Many athletes look up to him and every time they are around him they are smiling and laughing. It is his first year teaching and he already has students who look up to him as a role model. Comparing the years of experience they have can show the similarities and differences between how they talk about their teaching styles, their inspiration that made them decide to be a teacher, and the memorable experiences they have had as a teacher.

Rabies is a highly infectious viral disease that can easily ruin and eventually end the lives of both humans and animals alike. Rabies comes in two forms for animals. It comes in the form of paralytic rabies, which is the kind that puts you in paralysis right from the beginning, skipping the symptoms of agitation and excitability. Rabies also appears in the form of furious rabies, which is completely different in the way that it makes the victim restless, vicious and agitated. When humans get rabies, their symptoms start out with simple headaches and fevers and later progresses to terrible things such as becoming hydrophobic because of painful throat spasms and paralysis. A definite diagnosis of rabies needs lab analysis of

The HIV-1 virion is approximately 120 nm in diameter, roughly spherical, and is composed of two copies of a single stranded positive sense RNA enclosed by a capsid (24). The HIV-1 genome is less than 10 kb and encodes for more than nine different gene products. It encodes for 3 major structural protein genes: gag (group-specific antigen), pol (DNA polymerase), and env (Envelope), which code for major structural proteins and essential enzymes. Gag generates the mature Gag protein matrix (MA or p17), capsid (CA or p24), nucleocapsid (NC or p7), and p6, which encompass proteins for the basic infrastructure of the virus such as the inner core of the viral particle (25). Pol encodes for reverse transcriptase (RT), which enables the virus to reproduce, integrase (IN), which is necessary to integrate the viral double stranded DNA into the host genome, RNAse H, and HIV protease, which are all encapsulated in the core of the inner particle formed by the viral capsid protein p24 (25). Env encodes for glycoproteins of the outer membrane such as outer gp120 (which enables the virus to attach and fuse to cells of the host), and transmembrane gp41 that anchors the glycoprotein complex to the surface of the virion (25). Between the core and the envelope is the HIV matrix proteins which are composed of the viral protein p17 (23). HIV-1 also encodes for proteins with important regulatory elements (tat (Trans-Activator of Transcription) and rev

Because rabies is transmitted through saliva, the disease is usually brought about into the body by a bite of an animal already infected with the lyssa virus (rabies). Rabies then deposits itself into the tissue of the host (person/animal who has the virus in them), infecting the host and later multiplying. From there, the virus travels from the nerves to the muscles, then to the brain and spinal cord (Easmon paragraphs 8-9). At this point, the virus is multiplying rapidly and soon the brain is extremely affected, which causes it to malfunction and the part of the brain that controls breathing shuts down (Buncombe paragraph 8).