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Rheumatoid Arthritis Research Paper

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Rheumatoid arthritis (RA) is a chronic, complex and systemic inflammatory disorder that affects up to 1% of the population (1-2). It’s an autoimmune disease of unknown etiology. RA is associated with progressive joint destruction, systemic complications and early morbidity. The disease is characteristic of inflammation of the synovium, autoantibody production, cartilage and bone destruction and other systemic consequences, many of which include cardiovascular events. Although structural changes can be visualized by conventional imaging techniques, joint damage is rarely apparent in early stages of disease, but rather accumulates over time (3). Various immune modulators and signalling pathways are involved in the pathophysiology of RA. The influx

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