Sterigmatocystin (ST) is a carcinogenic polyketide [12] produced by species in several fungal genera. Microfungi capable of producing ST are common food, feed and indoor contaminants, and may also be plant and mammalian pathogens, thus having a large economic impact for the biotechnological, agricultural and food industry [12, 13]. Nanotechnology plays an important role in the fabrication of different nanoparticles that can exhibit novel antimicrobial properties [14]. The nano-scale of metals play roles in understanding the ability to manipulate biological processes which will be the central theme for present biomedical and biological issues that need a nanoscience or nanotechnology approach [15]. Shahverdi et al [14] …show more content…
Moreover, selenium has also been found to trigger the generation of ROS, with both elements capable of reacting with intracellular thiols and forming intermediates that cause oxidative stress as a consequence of the formation of superoxide radicals [21, 22]. Nanoparticles can contribute to functional damages of cell membrane or wall by disrupting the integrity of these important envelopes [23]. Selenium nanoparticles (SeNPs) have become the focus of intensive research owing to their wide range of applications in areas such as antioxidants [14, 24- 26], antibacterial activity [16] and anticancer [16, 27] applications. However, so far not much has been reported on the evaluation of antifungal activity of SeNPs. Studies of Shahverdi et al [14] have shown that antifungal formulations in the form of nanoparticles could be used as potential fungicidal material. It has been found that SeNPs exhibit low cytotoxicity compared with selenium compounds and possess excellent anticancer and therapeutic activities making them apt for medical applications [28, 29]. SeNPs have anticancer activity against kidney, breast, and lung [30, 31] and hence, can be used as chemopreventive and chemotherapeutic agents. On the other hand, SeNPs synthesized from a biological source possess a significant antimicrobial activity against pathogenic bacteria, microfungi and yeast [32].
The aim of this study was to investigate the complete inhibition of three toxigenic
These findings are significant because super-resistant bugs are already rampant in hospitals, and are only one mutation away from exploding into an epidemic of untold scale. Consequently, the researchers view quantum dots as a figurative platform technology, upon which more advanced methods can be tested against a wide range of infections, with a possible expansion into therapeutics on the
Selenium is an essential trace element found in the body that works in conjunction with other vitamins to support the powerful detoxification process. When combined with Vitamin E, Selenium can help prevent oxidative stress from occurring in the body which is crucial in the prevention of many diseases such as heart disease and cancer. According to Dr. Mandal (2015), "Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants." Selenium goes to work in the body as a powerful antioxidant, and it is required for the production of Glutathione, which is a key antioxidant in our bodies. Antioxidants are important in keeping the body healthy by fighting off the free radicals that our cells are exposed to on a daily basis.
The biological method of quantum dot synthesis using F. oxysporum has been proven to successfully synthesize highly photostable and luminescent QDs in an environmentally friendly manner. However, in order to increase the demand for biological methods of production, the yield of QDs synthesized by this method must be increased. This study considers several factors that affect QD synthesis by fungi and modifies them in F. oxysporum in order to increase QD yield. The fungus, F. oxysporum, was treated with osmolarity, pH, heat shock, and light intensity conditions and the resulting QD yields were compared to that of their controls, which were synthesized under the commonly used protocol for QD biosynthesis. Quantum dot yield was
[6]Fernandez-Gomez, Francisco J., Maria F. Galindo, Maria Gómez-Lázaro, Victor J. Yuste, Joan X. Comella, Norberto Aguirre, and Joaquín Jordán. "Abstract." National Center for Biotechnology Information. U.S. National Library of Medicine, 17 Jan. 2005. Web. 08 Oct. 2014.
The preparation of the selenide organometallic precursor, trioctylphosphine selenide, was done by dissolving 0.1 mol of a selendie shot in 100 ml of trioctylphosphine, therefore resulting in a 1M solution of trioctylphosphine selenide. Dimethylcadmium was used as the other organometallic precursor. The CdSe quantum dots were synthesized via the pyrolysis of dimethylcadmium and trioctylphosphine selenide in the co-ordinating trioctylphosphine oxide solvent. Precursors were injected at 350oC and dots were grown at 290oC. Selective size precipitation was performed with methanol to collect the quantum dots as powders, then quantum dots were redispersed in hexane. 5g of trioctylphosphine oxide was heated until it reached 190oC under a vacuum and
Research Theme: Building on the building blocks of life: Nanoscale materials for investigating biologically inspired and environmentally important systems.
Notwithstanding the immense progression in the cancer chemotherapy field, small-molecule drugs even though they were highly potent, were risky due to their non-specific toxicity due
In the year 2000, the National Institute of Health (NIH) started the National Nanotechnology Initiative (NNI) as a federal government program for facilitating and promoting the different nanoscience related research. In order to accomplish the target the NNI was launched as a broad program. The main aim behind of establishing the NNI was to coordinating and supporting the study, design, and exploration of nanomaterial. With extensive effort and support of NNI, the research related to health science was highly influenced and become revolutionized. Due to this impact the US government given the financial support to a good deal of research and development program and launched the interdisciplinary research. The new concept ‘Nanomedicine’ is also a result of merging the ‘Nanoscience and Nanotechnology’ discipline with ‘Medicine’. Similarly, the pharmaceutical scientist also adopted a terminology ‘Nanoscience’, and created the ‘Nanopharmaceuticals’ [1].
In many of the above studies easy entry of the nanoparticles was facilitated either by leaky BBB in the case of brain tumor or by the effect of TAT peptides, lactoferrin etc conjugated to the nanoparticles. 2c-j Herein we report the use of gold cluster of very small size to target the brain, in the early stages of disease, when the barrier is not much distorted.
Nanotechnology has become something of a buzzword in recent times. This is primarily due to it being a new and emerging science, but also because of its amazing applications and uses. Nanotechnology encompasses a varied array of subcategories in chemistry, biology, and physics. Generally, it includes all particles which are on the order of 1 billionth of a meter. [1]. As the particles involved are this small, it allows a variety of new technologies as well as new options for the treatment of diseases. Cancer is but one of these few diseases which nanotechnology has presented a new and refreshing chance to find a treatment. Cancer can be defined by anomalous and invasive
Center for Environmental Nanoscience and Risk (CENR), Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, United States
2.2. Oxygen binding Today scientists try to explore the chemistry basis behind the biological processes. As a result of this, new areas have evolved such as bioinorganic chemistry and bioorganic chemistry. In this section we will talk about an important concept in bioinorganic chemistry called “Metallobiomolecules”.
aElectrochemistry Research Group, Chemistry Department, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudia Arabia
In the past decades, the field of science and technology evolved, and flourished with many inventions and advancements. Everyday, our science community continues to come up with new ideas to improve the world, especially in nanotechnology industry. The technologies that scientists have developed have greatly impacted the world. New technological discoveries are constantly being made in this this field, and projects are underway that will soon be used in the future years. The expansion of nanotechnology will improve the lives of many citizens because scientists are currently implementing the findings into the environment, engine oil industry, and medical field.