Summary: The Endocannabinoid System

As per Healthy People 2020 most Americans do not consume healthy diets and are not physically active at levels needed to maintain proper health. As a result of these behaviors the nation has experienced a dramatic increase in obesity in the U.S with 1 in 3 adults (34.0%) and 1 and 6 children and adolescents (16.2%) are obese. In addition to grave health consequences of being overweight and obese. It significantly raises medical cost and causes a great burden on the U.S medical care delivery system ("Healthy People 2020," 2014, p. 1).

How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for profound healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for its matched exocannabinoid activator. This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. This is the primary control system that maintains homeostasis; our well being.

Cannabis is in fact an extremely popular recreational drug around the world, just behind alcohol, caffeine, and tobacco. Tetrahydrocannabinol’s (THC) primary psychoactive effect is a state of relaxation, and to a lesser degree, forms of euphoria. Secondary psychoactive effects of THC are that of philosophical thinking, introspection, metacognition, in anxiety and paranoia cases. The psychoactive metabolite of THC produced in the liver (11-OH-THC)

In recent years, obesity rates continue to grow in the United States, not just overweight, socialization difficulties, but it is a society that is developing a new medical condition. However, a worrying number of overweight Americans living with this abnormal condition does nothing to fix their obstacle, satisfies with light diets, and few minutes a day of exercise. ''While the number of obese adults has doubled since the 1980s, extremely obese adults has quadrupled, currently affecting one in every 50 adults, an estimated 300,000 people in the United States die annually from obesity-related diseases'' (O’Donnell, par.4). Unfortunately, years ago obesity were not an overwhelming problem in proportion, as now, each person has to prevent the number of calories to consume a day to be in the healthy average. Across the country, obesity is an epidemic that affects the quality of life, because unbalanced diets cause our body’s improper nutrition and deficient the essential vitamins and minerals our bodies require. Obesity should not be seen as an epidemic, instead as a medical condition that can be solved and controlled through the following years.

Synthetic cannabinoids were created to bind the same receptors as the active compound in marijuana, Δ9-tetrahydrocannabinol (THC), cannabinoid receptors CB1 and CB2 to obtain the psychotropic effects such as euphoria. CB1 receptors are located within the cerebral cortex, hippocampus, basal ganglia, cerebellum, in addition to peripheral organs such as the lungs, liver, and kidney. CB2 receptors are noted to be located on immune and hematopoietic cells, therefore desired and toxic

How dope subdue solicitude impartial during exercise (or elsewhere) modify far. Some users essay it lower their anxiety and may even gloominess resistance in the air passage, which would potently prosecute some act service. Other users recite increased feelings of solicitude and paranoia. legislation explain gage as all parts of the marijuana sativa artifice, which contains over 700 alchemical constitute. The first nimbleingredients are cannabinoids, embody THC, which is trustworthy for psychotropic effects and is the most deliberate. Peak rake concentrations of cannabinoids appear throughout 3-8 exact after you inhale, as antipathetical to 60-90 minutes after you victuala underbrush- or smear-include food, with nerve realization opening after 20 detailed and maximizing within a range of 2-4 hours. Cannabinoids tie cannabinoid receptors on neurons and external cells, receptors which are normally promised by natural endogenous substances (called endocannabinoids) that your strength already

During the featured article “how to make your exercise high last,” the author, S. Angle, describes the high you receive during and after a workout. This high is a feeling that you can’t miss, it happens after a great workout is finished, this feeling puts one's self in an astounding mood, plus making you ready for your next workout. The only problem with this is that it simply lasts for about 20 to 30 minutes before the feeling begins to go away. Studies by Johannes Fuss, Ph.D., the lead research of this study, have recently proven that this high feeling that many people enjoy are from our levels of endocannabinoids, and endorphins being at high levels. Endocannabinoids tend to have a more powerful effect on how we feel. Firstly, Endocannabinoids

CBD has positive effects on reducing and managing psychotic, anxiety, and depressive-like behaviors. The mechanisms appear to be related to the CBD's benefit to provide enhanced neuroprotection and inhibition of excessive neuroinflammatory responses in neurodegenerative diseases and conditions. Common features involving neuroprotective mechanisms influenced by CBD—oxidative stress, immune mediators, and neurotrophic factors—are also important in conditions such as posttraumatic stress disorder (PTSD), postconcussion syndrome, depression, and anxiety. Many studies confirm that the function of the ECS is markedly increased in response to pathogenic events like trauma. This fact, supports the role of cannabinoids and their interactions with CB1

According to report of survey of 2007-2008 by National Health and Nutrition Examination Survey (NHANES) by Ogden (2010) approximately 32.4 percent of adult population of US above 20 years of age have a basal metabolic interest (BMI) over 25 which indicate that they are overweight. About 33.8% of adults above 20 years of age are obese (BMI>30) and 5.7% are extremely obese (BMI > 40). These figures are alarming and obesity is of serious health concern. Americans are less physically active. The price of food in America has declined significantly due to changes in technology which have improved the effectiveness of food production and its distribution. Additionally, technology has reduced the requirement for physical activity during work or for movement. For most Americans, doing physical exercise requires a conscious dedication to exercise, which comes

Marijuana mysteries: 5 things we still don’t know about cannabis and how it could affect our bodies

The world of medicine is getting stronger everyday with fighting of common diseases. However, while this may consider medical drugs with healing abilities, there are drugs that are changing every year to adapt to legal issue. This drug is synthetic cannabinoids or commonly known as spice. Synthetic cannabinoids have many different names based on the strength, but will be referred to as spice in this paper. The research has been lacking in what actually happens under the conditions of spice because of the adaption that happens everyday. Three scholars, Max Spaderna, Peter H. Addy, and Deepak Cyril D’Souza, wrote an article in Psychopharmacology journal indicating everything that we know about synthetic cannabinoids to date. These scholars mostly use Logos as an appeal approach to their paper, but these appeals can be turned into a Pathos perspective with exigence weaved into the paper. Overall, this paper is an informative article about what can happen with the use of cannabinoids. This will explain why, people in general, need to know more about this synthetic drug.

The cannabinoid receptors are present throughout the body. Researchers have identified two cannabinoid receptors the cannabinoid receptor type 1 or the CB1 receptors and the cannabinoid receptor type 2 or CB2 receptors. The CB1 receptors are mainly found in the brain and the nervous system. Furthermore, CB1 is the main receptor for the photocannabinoid THC and its twin, anandamide which is one of the body’s naturally occurring cannabinoid which THC mimics or mirrors. On the other hand, CB2 receptors are found mainly in the immune system and its associated structures (Kossen, n.d.).

Bioactive lipids or lipids that activate specific signalling pathways are involved in the regulation and maintenance of normal bodily functions. Furthermore, bioactive lipid targets have been implicated in a number of conditions such as cancer, asthma and arthritis, all of which contain an inflammatory element. Additionally, a number of bioactive lipids are also known to target several different types of receptors. These include the cannabinoid receptors, peroxisome proliferator activated receptor alpha (PPARα) and transient receptor potential vanilloid-1 (TRPV1) ion channels. The assessment of bioactive lipid levels in biological systems is important for understanding their role in cell function and pathological

Many regions of the brain contain cannabinoid receptors, of which anandamide molecules, concerned with regulating mood, appetite and emotions, naturally bind to. Cannabis contains an active ingredient known as ‘delta-9-tetrahydrocannabonic’ (THC), and when smoked or eaten, the THC imitates the activity of anandamide by binding to cannabinoid receptors on nerve cells, and therefore influences

In Cannabinoid Hyperemesis Syndrome Masquerading as an Eating Disorder, authors Dr. Timothy D. Brewerton and Dr. Odette Anderson present the clinical case report of a 22-year-old female with Cannabinoid Hyperemesis Syndrome (CHS). It provides a clear description of what CHS is and how it effects someone with the syndrome. Brewerton and Anderson take the reader through the full process of someone with CHS. They start by laying out the reported symptoms, the diagnosis, and the treatments for the syndrome. The authors also discuss the pathophysiology and the different theories of CHS. The purpose of this case report is to provide the facts on CHS and what causes the syndrome. The intended audience for this case report is field professionals studying marijuana and its effects and those who have a good knowledge on the subject.