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Support Vasopressors Failure System

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The interventions should be focused on supporting the failing system and include the following: “(1) fluid replacement, (2) airway management, (3) antibiotic therapy, and (4) use of vasopressor” (Latto, 2008, p. 197). Fluid replacement is necessary to expand the blood and plasma volume in order to provide the adequate tissue perfusion and oxygen delivery to the organs. Vasopressors (dopamine, norepinephrine, epinephrine vasopressin) should be used in case the fluid replacement therapy fails to maintain adequate arterial pressure (Latto, 2008). The target central venous pressure should be more than 8 mmHG, the target central venous oxygen saturation should be over 70%. Wide-spectrum antibiotic should be administered as soon as the blood cultures are taken in order to treat the cause of the disease. Serum lactate level should be measured and treated with fluids “if greater than 1.5 times the upper limit of normal” (Latto, 2008, p. 198). Lactate is a byproduct of anaerobic cell metabolism and is one of the indicators of inadequate tissue oxygenation related to sepsis. Moreover, the glucose level, hematocrit and hemoglobin should be closely monitored. …show more content…

Ibuprofen: antiinflammatory and antipyretic actions; COX-1 and COX-2 inhibitor, nephrotoxicity and GI bleeding are the major side effects (Skidmore-Roth, 2013). Greisman & Mackowiak (2002) stated, “Ibuprofen did not improve survival in patients with sepsis, even though the drug did have a salutary effect on core temperature and metabolic rate” (p. 243). Considering the patient’s risk for renal failure, ibuprofen is not recommended. Moreover, if activated protein C treatment is considered, ibuprofen is contraindicated, since it might increase the risk for internal bleeding. Therefore, acetaminophen is the drug of choice for

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