preview

Sustained Release Analysis

Decent Essays

Time released supplements are dissolved slowly and deliver a steady amount of vitamins over a period of time. Sustained release has a longer half-life and produces stable levels of the vitamin throughout the day (Cascade, Kalali, & Weisler, 2008). They are enteric coated, which protects them from being digested in the stomach. They contain tiny pellets of the vitamin, each individually coated so that their contents are steadily released overtime (United States Pharmacopeia, 2012).

Extended release is designed to prolong absorption of vitamins with shorter half-lives. This allows for longer dosing intervals and decreases fluctuations in serum levels (Perucca, 2009). One example is extended release niacin which helps avoid side effects of flushing …show more content…

(2015). Sustained-release, extended-release, and other time-release formulations in neuropsychiatry. J of Clin Psychiatry. 76(8) e995-999. doi: 10.4088/JCP.15f10219.

Buchholcz, G., Kelemen, A., & Pintye-Hódi, K. (2014).Modified-release capsules containing sodium riboflavin 5'-phosphate. Drug Development And Industrial Pharmacy, 40(12): 1632-1636.

Cascade, E., Kalali, A. H., & Weisler, R. H. (2008). Short-acting versus Long-acting Medications for the Treatment of ADHD. Psychiatry (Edgmont), 5(8), 24–27.

Greenberg, S.M., et al. (1961). Human availability studies of five vitamins in sustained release form. The American Journal of Clinical Nutrition, 9(3): 324-330.

McCormack, P. & Keating, G. (2005). Prolonged-release nicotinic acid: a review of its use in the treatment of dyslipidaemia. Drugs, 65(18): 2719-2740.

Ooi, SY., et al (2016). Cellulose nanocrystals extracted from rice husks as a reinforcing material in gelatin hydrogels for use in controlled drug delivery systems. Industrial Crops and Products, 93, 227-234.
Perucca, E. (2009). Extended-Release Formulations of Antiepileptic Drugs: Rationale and Comparative Value. Epilepsy Currents, 9(6): 153-157. Doi:

Get Access