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Synthesis Of Obesity

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Many studies have been carried out to determine the genetic base of obesity. As result, mono and polygenic obesity have been revealed by scientists with the polygenic form stated as the most common. More than 100 and 200 genes respectively in human and mice have been identified to be related with obesity. As example, a defect in the gene coding for leptin, a hormone involved in regulation of appetite, abnormalities enzyme prohormone convertase that convert the hormone proopiomelanocortin (POMC) into neuropeptides, can deregulate energy metabolism. Genome wide scans in different ethnic populations have identified major obesity loci on chromosomes 2, 5, 10, 11 and 20 [9]. Recent genetic studies have identified several different causative mutations
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