# Since the mid to late 1950’s, Thalidomide has been a controversial drug. Since its introduction it has seen its highs and its lows. From devastating birth defects, to a treatment for some life threatening cancers, Thalidomide could be considered the Jeckel and Hyde of the pharmaceutical world. The question that the pharmaceutical world is asking itself now is weather the risk of the possible devastating birth defects that can happen is worth the possible life saving benefits that could be gained. Thalidomide has been the topic of debate since its uses as a treatment of certain cancers has been discovered.
# The drug was first introduced in the Europe. Thalidomide was prescribed to pregnant women to try and combat morning sickness.
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That is what scientists are trying to find out.
# After seeing the risks involved with Thalidomide, from birth defects to possible nerve damage, you might be asking yourself why anyone would ever consider taking such a drug. The answer to that question is that they would consider the drug as a last hope, or to prolong or add comfort in their final days. When a person is given no hope for a cure, any possibility becomes what could be the light at the end of a very dark tunnel. In some situations, conception is the last ting on their mind, so the possibility of birth defects is out of the question.
# Researches have found that Thalidomide can inhibit the growth of HIV in test tubes. (aegis, 2002) This is a glimmer of hope to a hopeless disease. Other benefits an HIV patient could get from Thalidomide are treatment of mouth ulcers and chronic wasting, two of the most debilitating symptoms of the disease. Trails for the drug have been limited and research is still in its early stages. Thalidomide is, by no means a cure for HIV or Aids, but it is, at this point, a very hopeful treatment.
# Imagine being a parent of a child with a life threatening form of cancer. The doctors have just told you your little girl has only six weeks to live. You start doing the things you think a parent on your situation should do, spending a much time as possible with your child. In your frantic search for a glimmer of hope in this, your darkest time, you come across
With the level of technology at where it is today there are many risks involved with many treatments. What the companies tend to do is advertise products and try to make the risks seem small. Every time you watch TV nowadays there is a commercial on there about a treatment that has
The main focus of this article is Richard Nares, a grieving father, who has become a hero in the eyes of many children fighting cancer. Nares has had a huge impact on two-year-old Sisi Johnson who has neuroblastoma. Sisi’s mother does not have a car and struggles to transport her daughter to and from chemotherapy as much as six times a week. Nares, who lost his son, Emilio, to cancer in 2000, has started a program called “Ride With Emilio”. This program provides transportation for low-income families with children battling cancer. The program has hundreds of patients who receive free rides to and from their cancer treatments. Nares met
Many Americans continue to believe that if a medication has been approved by the FDA it is safe for us to use, but the facts are many times they are not. You only have to look at all the medications that have been pulled from the market after many people lost their lives or had their health decay from these medications to know that nothing could be further from the truth. It helps to find a physician who will tell you to change your lifestyle rather than prescribe a pill that might have harmful side effects.
The importance behind this health issue is that major advances in medicine haven’t significantly improved survivor rates nor have medical advances reduced the number of cancer cases per year in children under 18 years of age (Curtin, Minino, Anderson, 2016).“Congressman McCaul is a father of five and knows that every parent’s worst nightmare is their children receiving a life-threatening cancer diagnosis. Growing up, his childhood best friend lost his battle to cancer. It wasn’t fair then and it isn’t fair now. Congressman McCaul founded the Childhood Cancer
The unregulated sales of Thalidomide also caused emotional distress and hardship for the future lives of mothers and their infants. The fatal drug 's side effects were displayed in pregnant women’s newborn babies. Infants affected with Thalidomide were born with limb reduction anomalies, congenital heart disease, ear malformations, and ocular abnormalities. The potential to live a long life was inhibited by the handicapped ailments each infant received. This created a lot of health expenses and difficulty obtaining an education. It is also very physically-challenging to perform everyday tasks causing many victims to often experience guilt and depression when realizing how unfortunate their circumstances
According to the Centers for Disease Control and Prevention (CDC), birth defects results in one of every 33 babies. Teratogens account for 4 out of 5% of birth defects when chemical and drugs are in the system. The use of this or even infections can cause abnormal fetal development.
After reviewing the article it is clear that more needs to be done to create transparency in the study of drugs and public awareness. As a doctor in Canada Dr. Navindra has a right to access and study information so he can provide due diligence to his patients. If the study found that this drug was harmful to pregnant mothers,
In general, with every pregnancy there is a 3-5% chance of having a baby with a birth defect. If a woman takes Thalidomide during her first trimester of pregnancy, the chance of her giving birth to a child with a birth defect increased to a 20%+ chance and the fetal and infant death rate is estimated to be 40% or more due to severe birth defects. (Thalidomide Side Effects on Babies). A portion of the children who suffer from birth defects caused by Thalidomide also suffer from developmental disabilities such as autism. Thalidomide victim survivors still suffer from these symptoms today. How does Thalidomide create all of these issues? The answer is science. The placenta is a very important organ that develops in the womb during pregnancy. The placenta nourishes the baby through through the umbilical cord and gets rid of all waste. The placenta is the first line of defense for the baby. It is a barrier that many harmful substances do not have the ability to cross. Before a pharmaceutical is offered to
This past summer, I, along with my mother and father, travelled to St. Jude Children’s Research Hospital in Memphis, Tennessee. My mom had been invited to participate in the St. Jude For Life Study because when she was around six to eight years old, she had a form of leukemia called Acute Lymphoblastic Leukemia. This particular study is to help all present and future St. Jude patients and help to research for a cure. While there, I saw first-hand how cancer can affect a family. You can just see all of the stress, the worry, the exhaustion, the tiredness, the fear, and the tears on the families’ and the patients’ faces.
Although the FDA approved the use of Zofran only for the treatment of nausea and vomiting in cancer patients, GSK promoted the drug to physicians as a viable treatment option for pregnant women experiencing severe nausea. This would later prove ill-advised.
In the late 1950s, the Thalidomide drug was used in Europe to treat morning sickness in pregnant women among other things. This study involved manufacturing company providing samples of this drug to physicians and compensating them to study the benefits and results of this drug. Although allegedly this drug did not cause any harm to the mother the fetus suffered severe damage as a result. There were thousands of children born with
As established in the National Cancer Institute, “Cancer is the leading cause of death worldwide for children and adolescents in America, accounting for more than 91,250 children that lose their lives to this disease” (National Cancer Institute). Cancer is not considered a terminal illness, but more of a chronic illness because of the intense treatment that the individual has to endure. As a result of this treatment the chances of survival for children suffering from pediatric cancer has increased around 80 percent. The increment in the survival rate has made it possible for many parents to not have to go through the acceptance that they are about to lose their child to a terminal illness, but have coping strategies that will make them adapt to the fear of the reoccurrence of that illness. This illness has a great impact on the patient as well as the family because not only do they have to adapt to this illness physically, but also mentally. Research has shown that there are both short term and long term effects that come into effect when the child is both in treatment and also years after the treatment. The type of cancers that these adolescents have to endure range from leukemia, brain tumors and other cancerous tumors that have appeared in recent medical studies. These tumors can either be benignant, an acute case that is non-cancerous or malignant, a cancerous case that will need intense treatment over an extended period of time.While many would say there is more of a
Why it is important in our society to know what teratogen is, and some ways to prevent this birth defect in our society. Teratogen is a agent that disturbs the development of an embryo. Well, what exactly causes these disturbances in the embryo? By taking medicine during pregnancy, medicine prescribe to new mothers can cause abnormality in pregnancy. Although many women take medications during pregnancy, the medicine prescribe can be harmful. A example may be a woman during pregnancy comes across morning sickness; therefore, she may ask her doctor to prescribe medicine to treat her morning sickness. A common medicine to take during the 60's was thalidomide. However, over the years researchers found that thalidomide caused partial absence
chemicals. Many women, who took diethylstilbestrol (DES) to prevent miscarriages, increased the risk for breat cancer in their children.
David Salsburg of Pfizer Central Research has noted that of 19 chemicals known to cause cancer in humans when ingested, only seven caused cancer in mice and rats using the standards set by the National Cancer Institute. This justifies that many substances that appeared safe in animal studies and received approval from the U.S. Food and Drug Administration for use in humans later proved dangerous to people. The drug milrinone, which raises cardiac output, increased survival of rats with artificially induced heart failure; humans with severe chronic heart failure taking this drug had a 30 percent increase in fatalities. Also, the antiviral drug fialuridine seemed safe in animal trials yet caused liver failure in seven of 15 humans taking the drug (five of these patients died as a result of the medication, and the other two received liver transplants). Scientists and the populous that do not agree with