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The Effects Of Psoriasis On The Development And Exacerbation Of Psoriasis

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Stress as an Influencing Factor in Psoriasis,
Psoriasis is a chronic, inflammatory skin disease with an approximate 2-3% prevalence in the general population. The etiology of psoriasis is not fully understood, but it appears to be multifactorial, involving both genetic and environmental influences. Among these factors, emotional stress is considered to play an important role in the onset and exacerbation of psoriasis.
Emotional stress may influence the development and exacerbation of psoriasis. The proportion of psoriasis patients who believe stress affects their skin condition (i.e., “stress responders”) is considerably high, ranging from 37% to 78%. Stress may worsen psoriasis severity and may even lengthen the time to disease clearance. Dysregulation of the hypothalamus-pituitary-adrenal and sympathetic adreno-medullary systems has been proposed as one possible underlying cause of stress-induced flares of psoriasis. While stress may be an exacerbating factor, psoriasis itself may contribute to significant adverse psychological sequelae. Breaking this stress cycle may be an important part of any therapeutic approach. Thus, stress reduction through psychotherapy and pharmacotherapy may be useful in treating psoriasis patients who are stress responders.
Significance of Stress in psoriasis,
Researchers examined 132 psoriasis patients whose psoriasis had completely cleared with anthralin therapy and were followed over 3 years. Fifty-one patients (39%) recalled specific

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