among other things, protein degradation through the ubiquitin-protease system (UPS) and the consolidation and reconsolidation of long-term fear memories. This research was necessary because, while research had been done linking protein degradation to synaptic plasticity, no study had been performed to analyze the role of UPS in the amygdala, where long-term fear memories are believed to be stored. Additionally, prior research had led to conflicting reports of the importance of protein degradation in consolidation
Fluorescent Protein was discovered to be responsible for Aequorea victoria's fluorescence under UV light (Niwa et al., 1996). Today, GFP is often used in protein tagging and has made it possible for scientists to study expression and track proteins in vivo. With the rising importance of GFP fusion proteins and other recombinant vectors, the metal affinity of Histidine helps to make the protein purification process easier (Lilius et al., 1991). His tags are commonly used to purify proteins through immobilized
immune function and frequently result in severe infections and in certain cases lead to death in children. In this regard, protein-energy malnutrition and Iron deficiency attract the greatest health concern. Protein–energy malnutrition leads to a reduction in phagocytic cells, secretory immunoglobulin A antibody response plus number and functions of T-cells. In developing world, protein deficiency in humans majorly contributes to mortality resulting from infectious diseases (35). Furthermore, epidemiological
Protein disorder in autophagy and its clinical importance: Autophagy is an intracellular reprocess route in eukaryotes whereby organelles and cytoplasm are sequestered in vesicles, which are subsequently release to the vacuole for breakdown. The process is build by various nutrient-responsive signaling cascades converging on the Autophagy-Related1 (ATG1)/ATG13 kinase complex. Synthesis of the ATG12-ATG5 and ATG8-phosphatidylethanolamine adducts, which are important for autophagy, still occurs in
Proteins are a special nutrient that play an essential role in athletic performance. Unlike carbohydrates and fats, proteins are not considered an immediate source of energy, but they are definitely considered a backup. They are the go to nutrient, “to help the body build and repair muscles, make red blood cells, maintain enzymes and hormones, and allow hair and fingernails to grow,” (Averbuch & Clark, pg.66). It is important that athletes understand the significance of a well-balanced diet with
Glycophorin A (GpA) is a protein found in the human membrane red blood cell. The GpA protein is obtained from the gene called glycophorin A (MNS blood group) or GpA. The GpA gene bears the antigenic determinants for the MN and Ss blood groups, and 40 related variants of the Miltenberger complex and several isoforms of Sta1. There are two classes of membrane glycoproteins, asialo and sialoglycoproteins (glycophorins). These glycoproteins are determined by the presence of sialic acid which is the negative
Proteins, carbohydrates, lipids, and nucleic acids are all essential macromolecules for basic biological functions within an organism’s body, and other everyday applications. They are used in chemical reactions to achieve many results, such as energy storage, DNA coding, waste management, and a number of other uses. However, most of the chemical reactions involving macromolecules rely heavily on the shape and structure of the molecule; such as the amount of monomers in the macromolecule. The process
Adetutu Okupe Bio 2107k Lab Report Hieu Nguyen Importance of food Labelling Abstract: The Food and Drug Administration recognizes the importance of food labelling as a vehicle for dietary messages and, thus, enforces stringent guidelines to maintain the integrity of the food label. As food labels await another upgrade to make them more effective and easier to understand, the Food and Drug Administration considers what information will be most useful for consumers to make healthy choices. The causal
The ING (INhibitor of Growth) family of genes and proteins (ING1–ING5) was identified in 1996, from PCR-mediated subtractive hybridization between a normal mammary epithelial cell strain and several transformed breast cancer cell-lines, followed by an in vivo functional screen for tumourigenesis1. The ING proteins target histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes to the H3K4me3 mark, altering histone acetylation and gene expression2. ING4 was identified by computational
In the fitness world, protein shakes, powders, breakfast bars and many other edible products are promoted for athletes. Athletes are told, “When you work out, your body’s muscles create tiny tears in order to expand and grow which causes your muscles to be sore. By consuming large amounts of protein you are helping to patch those tears” (Burson). This encourages athletes to eat anything and everything that includes large amounts of protein. This understanding of protein’s role in