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The Importance Of Ratio

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Consistently, partial transection of spinal cord in our study leads to a significant increase in total white blood cells, neutrophils, and also N/L ratio, 3 days after SCI. SCI induces immune suppression and numerous organ dysfunction, such as bladder dysfunction, and seriously increases susceptibility to post-trauma infection . Therefore consistent with our results, administration of systemic antibiotics is recommended postoperatively. The value of neutrophil-to-lymphocyte ratio (N/L ratio) predict systemic inflammation, and also have significant correlation with stress (Zahed and Karimi Mahali 2015; Fawaz et al. 2017). N/L ratio is an easily measured and inexpensive index of subclinical inflammation. Additionally, it is characteristic …show more content…

2003), and inducing of differentiation as in the case of immature oligodendroctyes into myelin-forming oligodendrocytes (Gu et al. 1997). Selenite , as an oral form of selenium, reduces oxidation-induced apoptosis, via blocking of the serine/threonine kinase ASK1 and its downstream pathway SEK1- JNK (Yoon et al. 2002; Savaskan et al. 2003). There is some evidence that selenium regulates the inflammatory response, via several complex pathways (Duntas 2009), and as an extremely important component of the antioxidant enzyme system, may have a vital role in modulating the immunological parameters (Duntas 2006). The capacity of selenium as an anti-inflammatory component is related to its effect on immune cells, and especially on the macrophage signal transduction pathways (Duntas 2009). The other important anti-inflammatory mechanism of selenium is regulated via its effect on monocyte adhesion to endothelial cells and their infiltration toward tissues. Monocytes stick to the endothelium and are converted into macrophages, as the main effectors of innate immunity in inflammation (Cao et al. 2002). The monocytes adhesion to the endothelium is mediated by L-selectin, which simplify the neutrophil migration, during inflammatory response- mediated by different ligands. As oral

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