Specific Aims
Although the worldwide incidence of Head and Neck Squamous cell carcinoma (HNSCC) has been steadily declining over the past 20 years, it is still the sixth most common cancer by incidence with about 50% of mortality. Traditionally, the most notable risk factors for HNSCC are alcohol consumption and various forms of tobacco use, the combination of the two having a significantly synergistic effect on carcinogenesis. More recently, human papillomavirus (HPV)-associated oropharyngeal cancers are increasing and becoming a significant problem, especially in the young population. The reasons are unclear although it has been postulated that an increased practice of oral sex may be a factor.
Due to the species-specificity of papillomavirus, no preclinical model is available to directly study HPV-associated infection and persistence. Recently, we have established a mouse papillomavirus (MmuPv1) oral infection model. Viral infection was detected at the human equivalent sites in the infected mice, and advanced dysplasia was identified in the infected tissues. This model holds the promise to mimic HPV-associated oropharyngeal cancers.
More evidence demonstrates that tumor microenvironment has played a role in tumor outgrowth and progression. Multiple host defense systems, including host immune system, constantly fight against the invader, and their efficacy is directly associated with the disease outcomes. To understand the molecular mechanism of viral-host interaction
Summary of article: In “Bridging the HPV Knowledge Gap,” Christina Demopoulos and two others talk about the importance of knowledge on HPV and how most patients are unaware of this virus and that is it on the oral health professionals to educate them. This virus is transmitted easily through a small cut or tear in the oral cavity and is associated with a variety of oral lesion, cances, and oropahygnel cancers. The article included a statistic that about 12,000 people between ages 15 and 24 are affected everyday by HPV and its only increasing. HPV causes more than 30,000 cancer cases a year which the average age diagnosis is 62, but ther is arise of cases in the adolescents. With that being said, it is put on oral health professional to discuss the ipmo ratio of HPV with patients, and they should become more familiar with HPV because there is an association between HPV and oropharyngeal cancers. One way to bridge the HPV knowledge gap is to do what NEvada is doing. Nevada has a Immunization program which promotes for better health and they hold a lot of information conferences. Overall,
Almost all cervical carcinomas are caused by Human papillomavirus (HPV). Cervical cancer can be a life-threating disease. However, over recent years the occurrence of cervical cancer has declined as well as the chance of dying from it. A huge contributing factor to this decline is the importance of a regular pap smear. A pap smear can find cervical pre-cancer before it turns into cancer. Recently, a vaccine for HPV, has been on the market, which provides close to a 100% protection against pre-cancer and general warts. HPV and cervical cancer are two disease that are closely related. However, each disease effects not only similar populations, but also different populations, as well as having its own signs and symptoms, detection procedures,
Human Papilloma Virus, more commonly known as HPV, is a sexually transmitted virus. It is spread from skin-to-skin contact with an infected person, typically during sexual encounters. It is the most common sexually transmitted disease in the United States. According to the Immunize Action Coalition, “most sexually active American men and woman will contract at least one type of HPV virus during their lifetime” (A Parent 's Guide to Preteen, 2013, p. 1). To put the numbers in perspective, it infects an estimated seventy-nine million Americans today with approximately fourteen million more people being affected additionally each year (Human
Don’t smoke or drink alcohol. Drinking too much alcohol may cause oral or throat cancer, and using alcohol and tobacco together increases the chance of these diseases.
Human papillomaviruses (HPV) are a group of more than 40 types of viruses that infect the genital areas, throats (recurrent respiratory papillomatosis), and mouths of males and females and is the number one most common sexually transmitted disease (Center for Disease Control and Prevention [CDC], 2009). It is spread by genital contact. It is most easily spread by vaginal and anal sex, but also through oral sex and even just genital-to-genital (skin-to-skin). In 90% of people that contract HPV, their own immune system
HPV stands for the human palliloma virus. It is estimated that there are around 100 different types of HPV. The HPV virus can cause lesions to develop on the soft palate, tonsils and tongue. It can also increase the risk of certain forms of cancer, including oral cancer and cervical cancer.
Cervical cancer is the leading cause of cancerous death, in women, since 1950. Approximately 200,000 cervical cancer patients die each year in developing countries. Strains like HPV 16 and 18 cause about 70% of cervical cancer in women– one of the top causes of death in the world (WebMD, 2010, p.1). In the Unites States, about 10,000 women acquire the disease and 3,700 die annually Human Papilloma Virus (HPV) is directly associated as a cause of cervical cancer. This virus affects the skin and genital area and, in some cases, it can also infect the throat and mouth. Since the HPV is passed from one person to another through skin-to-skin or sexual contact, sexually active people are more prone to this virus. Merck
Human papilloma virus, or HPV, is a sexually transmitted infection, and the more sex partners someone has, the bigger their risk. Now, a study out this week shows there’s a silent epidemic of HPV-related cancers among men. In fact, the study found that men are more likely to be infected with cancer-causing oral HPV strains than women, suggesting there are more throat cancers in men than cervical cancer in women.
From 1998 to 2003, the incidence rates for HPV-associated cancers of the tonsils and tongue increased 3.0% per year, while non-HPV cancers of the mouth and throat decreased during this time (Ramqvist and Dalianis, 2010).
Human Papillomavirus (HPV) is a double -stranded deoxyribonucleic acid (DNA) virus that only infects humans with an attraction to both cutaneous and mucosal surfaces such as the cervix, anus, tonsil, and oropharynx (Clark, 2013). HPV is a type of oncogenic virus that goes into the cells and can cause several diseases. Over the years, research has surfaced connecting genital HPV to several types of cancer. There are over a hundred strains of HPV but the most high risk strains, 16 and 18, have been shown to cause vulvar, vaginal, anal, and the most concerning, cervical cancer (Chan, Ng, & Wong, 2012). Genital HPV
Human Papilloma Virus (HPV) accounts for the third most prevalent cancer in females worldwide,15 as it is the most common sexually transmitted infection (STI).2 There are more than 100 subtypes of HPV; 16 of those subtypes are known to be high-risk.15 HPV is a crucial precursor to cervical cancer in 99.8% of those affected,2 with subtypes 16 and 18 being the most common types.15
Though no exact cause for oral cancers is known, the American Cancer Society says that smoking or use of other tobacco products, heavy drinking and human papillomavirus infections have been shown to increase the risk of developing oral cancer. The use of alcohol and tobacco together increases the risk of oral cancer more than for people who don’t use alcohol or tobacco. Stopping the use of alcohol and tobacco products is the first step in decreasing your chances of developing oral cancer. Seeing your dentist regularly can help to detect any problems while they’re in the early stages.
Oral cancer in the mouth, head, and neck are half of the time caused by oral sex. Scientist have studied that the more you have oral sex the better your chances are to having oral cancer. Statistics have shown that “an individual who has six or more lifetime partners – on whom they’ve performed oral sex – has an eightfold increase in risk compared to someone who has never performed oral sex(Oral Sex). In our world today oral sex seems like a casual thing that happens with teens and young adults. Parents and doctors
As with most diseases, prevention is the best approach and even though there is no definite answer to why cancer develops, there are several risk factors that may suggest that oral cancer is probable. The use of tobacco and alcohol increase the risk of developing oral cancer as so does the incident of contracting a HPV infection, which is the Human Papillomavirus (Hill, Deitz, & Sax, 2014, p. para 6). According to recent studies, HPV is becoming the leading factor in patients with oral cancer. Patients should be assessed and screened for alcohol and tobacco abuse as well as the possibility of exposure to the HPV virus to determine their risk for oral cancer. Some other risk factors that may not be apparent are the exposure to the sun for prolonged periods of time without an effective sunscreen agent and a history of previous oral cancer (Hill, Deitz, & Sax, 2014). A comprehensive assessment should be performed to measure the probability of this patient developing oral cancer.
Blot1,WJ & McLaughlin, JK & Winn, DM & Austin, DF & Greenberg, RS & Preston-Martin, S & Bernstein, L & Schoenberg, JB & Stemhagen, A & Fraumeni, JF(1988), “Smoking and Drinking in Relation to Oral and Pharyngeal Cancer”, Cancer Res., Vol. 48.