The Influence Of PCI On The Human Body

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PCI causes mechanical damage, induces immune response and cascade inflammatory response, stimulates the proliferation of vascular smooth muscle cells and deposition of extracellular matrix, leading to neointimal thickening and restenosis. platelets, neutrophils, and monocytes play a central role in the initial inflammatory response after PCI,studies showed that Mac-1 and platelet mediated leukocyte adhesion play an important role in vascular inflammation and restenosis after coronary stent implantation. Platelets and fibrin are deposited on the vascular walls of the endothelium, and by a series of cell adhesion molecules they collect white blood cells into the damaged blood vessels. The initial platelet leukocyte binding and rolling through leukocyte receptor P- selectin glycoprotein ligand -1 (PSGL-1) and P- protein binding to platelet mediated, when the leukocyte integrin Mac-1 (CD11b / CD18) combined with platelet glycoprotein Ib alpha 53 or platelet glycoprotein IIb / IIIa binding protein fiber the original, leukocyte rolling stop and firmly attached to the adherent …show more content…

clinical studies in patients treated with PCI have demonstrated a significant increase in Mac-1 surface expression in neutrophils obtained in the coronary sinus of patients who have received PCI within the first 48 hours and high levels of Mac-1 are associated with an increased risk of late angiographic

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