The Middle East respiratory syndrome coronavirus (MERS-CoV) is a positive-strand RNA virus belonging to the C lineage of the Betacoronavirus genus. Since its identification in 2012 in a patient from Saudi Arabia, there have been seven hundred one laboratory-confirmed cases of MERS-CoV in eight different countries, boasting an alarming thirty-five percent patient fatality rate. Both alphacoronaviruses (alphaCoVs) and betacoronaviruses (betaCoVs) have been known to cause human disease, but a majority of cases only cause common cold-like illnesses in health adults. Some betaCoVs, however, have the ability to cause severe life-threatening pandemics, such as the severe acute respiratory syndrome coronavirus pandemic (SARS-CoV). In 2003, SARS-CoV, a B lineage betaCoV, infected more than eight thousand people worldwide, more than eight hundred of which succumbed to the virus. The important question that needs to be answered to shed some light on its origin as well as potential therapeutic approaches is why are some species susceptible to MERS-CoV infection while others remain resistant? Initiation of viral infections begins with viral particles binding to host surface cellular receptors. It has recently been determined that MERS-CoV infection is initiated by the interaction of MERS-CoV’s spike protein with dipeptidyl peptidase 4 receptor (DPP4; also known as CD26) on the surface of the host cell. The region of the spike protein responsible for the recognition of DPP4 was
The respiratory syncytial pathogen is a non-segmented negative -sense single stranded RNA virus that falls under the paramyxoviridae family. The virus is comprised of 10 genes the encode 11 proteins and is divided into two subtypes A and B, which further divide into multiple genotypes. Genetic studies have tried
Many people take breathing for granted, some never give it a second thought until a problem presents itself. Respiratory diseases affect millions of Americans as well as people from all over the world. Anyone can suffer from these disorders to include men, women, and children, with conditions ranging from mild, moderate, to chronic in nature. This paper will focus on one of the many respiratory disease called mycobacterium tuberculosis; more commonly referred to as TB.
Middle East Respiratory Syndrome (MERS) is a severe acute respiratory illness caused by the coronavirus named MERS-CoV. It is believed that the virus is found in camels and passed on to humans who are in contact or around infected animal. These camels are mainly located in Egypt, Oman, Qatar, and Saudi Arabia (WHO, 2015a). Those infected with MERS exhibit fever, cough, and shortness of breath, pneumonia, and diarrhea. Severe cases require patient to be put on mechanical ventilation or in an intensive care unit. It is also known to cause kidney failure and septic shock. The elderly, persons who are immunosuppressed, those who
In September of 2012, beginning in the country of Saudi Arabia, hospitals began seeing increased cases of a respiratory virus never before seen in humans. They named it Middle East Respiratory Syndrome, or MERS. MERS is a viral respiratory illness caused by the coronavirus. It was originally thought to have started there in Saudi Arabia. It was not until later that they were able to trace the origin back to Jordan starting in April of 2012. All outbreaks of MERS have been traced back to originating from the Arabian Peninsula (CDC, 2015a). Unfortunately, it is not known exactly how MERS was contracted in humans, but it is believed to have come from an animal source, probably from camels. Strains of MERS
RSV belongs to the paramyxovirus family of viruses. The virion encompasses a helical nucleocapsid packaged in a lipoprotein envelope attained from the host cell plasma membrane during budding. The external surface of the envelope contains a periphery of surface spikes.
What are the uses of drugs used to treat lower respiratory tract disorders: sympathomimetics, anticholinergics, inhaled steroids, lung surfactants, and mast cell stabilizers?
SARS is a respiratory infection caused by the coronavirus that was thought to have originated in Guangdong China but was not reported until
Respiratory problems have been a thing in canada as well in most countries. But Canada is becoming a high risk for influenza. To go more into depth about respiratory diseases it includes other breathing problems such as asthma,tuberculosis,bronchiolitis,emphysema,cystic fibrosis and pneumonia. In the past decade the number of people in Canada haven’t contracted the disease. Studies have shown that in canada that men have a higher chance to have COPD other that women,but women are more known to report it.
SARS (Severe Acute Respiratory Syndrome) is a respiratory illness caused by a coronavirus, originally reported in Asia in February 2003 and spread to over two dozen countries before being contained (Centers for Disease Control and Prevention [CDC], 2005). Once infected, individuals with SARS initially develop a high fever and other flu-like symptoms including headache, body aches and “overall feeling of discomfort” before, in most cases, progressing to pneumonia (CDC, 2005).
There is still a great deal of information to learn from the study of viruses and the continued exploration of the viral genome is crucial in understanding how viruses communicate, transmit from host to host and evade immune responses. The ever-change nature of the viral genome has shown us that the most dangerous viral infections of today may be undermined by newer and more effective viruses, resulting in catastrophic outcomes. Through the study of viruses, it is the hope of the scientific community to be ahead of the viral curve, preventing infections before they even
Respiratory disease affects the quality of life for many Australians. Common respiratory diseases that impact on health include Emphysema, Cystic Fibrosis and asthma. These illnesses and conditions can range from minor to life-threatening. This group of disease offers significant potential for prevention.
Croup accounts for 15% of clinic and ED visits for an upper respiratory tract infection and is the most common cause of acute stridor. Most often croup occurs in children ages 6-36 months of age but can be seen in older children up to age 6. Males are more prone to croup than females. Croup usually occurs in early winter and presents to the ED from 10:00PM to 4:00AM. Hospitalizations from croup usually are between 2-5% with 1% of those children requiring intubation and .5% of those intubated dying. Complications are rare but it is important to identify the treat these patients rapidly.
A number of studies have supported the theory that the virus had originally occurred in animals previous to human infections.5 The MERs-CoV virus is a type of coronavirus that has been known for infecting both birds and many species of mammals. These types of infections are commonly referred to as zoonotic diseases because the pathogens are able to be transferred from animals to humans. Zoonosis can happen with or without a vector in order to spread the infection. Although the exact origin of the MERs-CoV infections is unknown, there has been convincing research performed that has found related types of coronaviruses in bats and camels. According to the Center for Disease Control and Prevention, the coronavirus is found in multiple species and can cause respiratory illness and gastrointestinal upset.
MERS-CoV is a respiratory disease that was first found in Saudi Arabia in 2012. This virus can cause people to get diseases such as the common cold to a Severe Acute Respiratory Syndrome (SARS).
Respiratory distress syndrome (RDS) is a common lung disorder that mostly affects preterm infants. RDS is caused by insufficient surfactant production and structural immaturity of the lungs leading to alveolar collapse. Clinically, RDS presents soon after birth with tachypnea, nasal flaring, grunting, retractions, hypercapnia, and/or an oxygen need. The usual course is clinical worsening followed by recovery in 3 to 5 days as adequate surfactant production occurs. Research in the prevention and treatment of this disease has led to major improvements in the care of preterm infants with RDS and increased survival. However, RDS remains an important cause of morbidity and mortality especially in the most preterm infants. This chapter reviews the most current evidence-based management of RDS, including prevention, delivery room stabilization, respiratory management, and supportive care.