The Prader Willi Syndrome ( Pws ) Is A Complex Genetic Disorder Caused By A Chromosomal Abnormality

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Prader-Willi syndrome (PWS) is a complex genetic disorder caused by a chromosomal abnormality. It is characterized by mild to moderate hyperphagia, severe obesity, intellectual disabilities, and behavioral and psychiatric difficulties. Characteristic behavioral disturbances in PWS include excessive interest in food, skin picking, temper tantrums, obsessive and compulsive behaviors, and mood fluctuations. It occurs in approximately one in 25,000 to 30,000 live births with no distinguishing sex or race association.
One of the most difficult challenges for those caring for individuals with PWS is hyperphagia—abnormally increased appetite and lack of satiety—and the subsequent obesity. Obesity-related complications of PWS, such a respiratory failure, diabetes mellitus, and congestive heart failure, have been recognized as the main causes of morbidity and mortality in individuals with PWS. Untreated obesity limits the life expectancy from 20 to 30 years old. The diminished chance of an individual with PWS to survive into adult life makes the treatment of eating behavior and the subsequent obesity mandatory. The causes of hyperphagia and lack of satiety are unknown, limiting the number conclusive treatment options available. Since the etiology of hyperphagia is unknown, current research lacks a specific direction. Possible interventions range from medical interventions to behavioral management procedures. A review of the literature on techniques for controlling eating,

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