The Role Of Nkt Organs In NKT Cells

Type II NKT TCRs are more prevalent in humans, yet, remain as one of the least functionally characterized NKT cell populations. However, with the advent of Jα18 gene KO studies, the role of type II NKT cells in antimicrobial immunity is progressively appreciated. A series of structural studies have provided the molecular basis of type I NKT TCR-mCD1d-Ag complex and demonstrated a distinct recognition pattern dominated by the CDR loops encoded by the germline region of the TCR. The parallel docking

NKT cells- Recent intravital studies on natural killer T (NKT) cells have provided novel insights on the role of these cells during host defence78, 79 and immune-regulation80, 81. NKT cells share characteristics of both NK and T cells, and therefore act as a bridge between innate and adaptive immunity81, 82. Unlike conventional T cells that recognise peptide-MHC complexes, NKT cells recognise pathogen or self-derived glycolipids displayed on the MHC I like protein, CD1d; and upon activation can release

Abstract: The last fifteen years have seen a reemergence of interest in cancer immunosurveillance and a broadening of this concept into one termed cancer immunoediting. The latter, supported by strong experimental data derived from murine tumor models and provocative correlative data obtained by studying human cancer, holds that the immune system not only protects the host against development of primary nonviral cancers but also sculpts tumor immunogenicity. Cancer immunoediting is a process consisting

no cure has been found for any autoimmune diseases so far. Autoimmune conditions may influence any tissues of the body, including skin (psoriasis), limbs (rheumatoid arthritis), endocrine glands (Hashimoto’s disease, type I diabetes) or digestive organs (celiac disease) ("Autoimmune Statistics - AARDA", 2016). Some of the autoimmune disorders exhibit slow disease course with feeble symptoms, while other disorders are manifested rapidly, imposing an immediate threat to patient’s well-being, and, sometimes

Self-tolerance occurs through two mechanisms. The first is central tolerance, which takes place in the thymus (T cells) and bone marrow (B cells) [2]. Central tolerance selects for individual B and T cells, which do not recognize self-antigens presented to them in the primary lymphoid organs, to continue maturation [2]. The second is peripheral tolerance, which occurs outside of primary lymphoid organs, where B and T lymphocytes are further selected for self-reactivity to antigens that were not presented

immunoediting will hopefully stimulate development of more effective immunotherapeutic approaches to control and/or eliminate human cancers. • HISTORY The concept of immunoediting is predicated on the insight that the immune system can recognize tumor cells. The notion that the immune system monitors the host, not only for pathogen invasion but also for neoplastic changes, arose early in the history of Immunology was first proposed by Paul Ehrlich in 1909 and then resurrected 50 years later by Burnet