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The Use Of Nanotechnology On Other Types Of Brain Cancer

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Glioma, a destructive type of brain cancer, and other types of brain diseases have been mostly untreatable due to the blood brain barrier (BBB). There have been drugs produced that are effec-tive in treating these diseases, but simply cannot bypass the barrier due to its special properties. It serves to restrict and control the movement of molecules in and out of the brain. In recent years, the use of nanotechnology show promise with their abilities to bypass the BBB to deliver drugs and small molecules into the brain. Gold nanoparticles (AuNPs) obtained the most interest, as it has been used in earlier applications, and their ability to be tracked by CT imaging or atomic ab-sorption. By first looking at the size of the nanoparticle, researchers were able to decide which size of nanoparticles would have the most AuNP uptake across the BBB. It was found AuNPs less than 50nm are the most ideal for the amount of delivery within brain cells. A precursor prob-lem of reaching the BBB is the protein corona. It labels AuNPs immediately when it enters the bloodstream for phagocytosis. By adding a hydrophilic surfactant onto these AuNPs, it allows for them to have an increase circulation time in the blood to reach the BBB and into the brain. The option of using adsorptive-mediated transcytosis (AMT) or receptor-mediated transcytosis (RMT) will allow nanoparticles to increase their permability acorss the BBB. By utilizing these techniques, nanoparticles are able to enter the brain with
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