Is axial length a risk factor for trabeculectomy failure?
Introduction:
Glaucoma has been recorded as a major cause of preventable blindness and myopia and high myopia (AL of ≥26.0 mm) has been recognised as a major risk factor for the development of glaucoma. Worldwide, the prevalence of myopia has been increasing; hence, the prevalence of glaucoma associated with high myopia has also been increasing. IOP-reducing treatments are the best evidence-based therapy for glaucoma as high intraocular pressure (IOP) was the most important factor associated with the development of glaucomatous damage. Trabeculectomy with use of antimetabolites has increased the success rate in such cases. However,many risk factors for trabeculectomy failure have been
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All patients received topical antibiotics and topical steroids for 1–3 months after the surgery. Sutures anchoring the conjunctiva and Tenon capsule to the limbus were removed after 1 month of the surgery. Postoperative interventions like digital ocular massage, laser suture lysis and anterior chamber reformation were recommended based on the IOP, conjunctival bleb shape, anterior chamber depth and presence/absence of complications. If a postoperative IOP elevation was due to insufficient filtration, laser suture lysis was recommended and if the IOP still remains high bleb revision surgery was performed. Surgical success was defined as an high intraocular pressure (IOP) of ≤21 mmHg (criterion A), ≤18 mmHg (criterion B), or ≤15 mmHg (criterion C), with a lower IOP cut-off of 6 mmHg and a [20 % reduction regardless of the use of antiglaucoma medication. Statistical tests were performed where P …show more content…
11.5 ± 11.7, P = 0.75) after the surgery.
• The 3-year success rates regardless of antiglaucoma medication use of the high myopia group and the non-high myopia group were 62.3 and 56.9 % based on criterion A (P = 0.78),
• 57.0 and 54.3% based on criterion B (P = 0.94) and 51.7 and 39.0 % based on criterion C (P = 0.55), respectively. Figure 1a-c
Figure 1: Survival analysis curve for the success of trabeculectomy in the high myopia group (19 eyes) and non-high myopia group (54 eyes). a- Survival analysis curve based on criterion A; b- Survival analysis curve based on criterion B; c- Survival analysis curve based on criterion C
Adapted from: Tanaka D et al.
• Younger age, preoperative and pseudophakia shorter AL was found to be significant risk factors for trabeculectomy failure based on an IOP of ≥15 mmHg (criterion C).
• Age and pseudophakia also had significant effects on trabeculectomy failure based on criteria A and B and the AL had a significant influence based on criterion A.
There were no intraoperative or postoperative problems. However in one patient elevated intraocular pressure (IOP) were detected at the postoperative control. Were considered steroid induced, the IOP returned to baseline levels after cessation of steroid. Throughout all follow-up years, a total of 5 eyes of 5 patients have been received a new intervention due to a tilt of the lens or had been dislocated from the iris. In this patients the endothelial cells loss was much higher than the
The eye retention is one of the main goals of the conservative treatment, but in some cases enucleation can be indicated due to complications after therapy e.g. secondary neovascular glaucoma (Furdova et al. 2005).
The guidelines of the European Glaucoma Society (EGS) for the management of glaucoma due to corticosteroid treatment are; (1) discontinuation of corticosteroid therapy or switch to weaker steroid (2) administration of topical or systemic IOP lowering medications (3) laser trabeculoplasty and (4) glaucoma surgery in intractable cases. These recommendations are, however, not specific for intravitreal administration of
Did you know that 9-12% of people are diagnosed with glaucoma. Glaucoma is a disease of the optic nerve, which is usually associated with high pressure inside the eye. Glaucoma has been labelled the “sneak thief of sight”, because people remain undiagnosed until irreversible vision loss occurs. About 1 out of every 10,000 babies born in the United States are diagnosed with glaucoma. Over 3 million Americans have glaucoma, but only half of them realize they have glaucoma. In this essay, it will discuss about the different types of glaucoma, different causes of glaucoma, and different treatments for glaucoma.
"Glaucoma is a condition that causes damage to your eye's optic nerve and gets worse over time". (WebMD) Glaucoma is interlinked with the pressure in the eye. No one knows the exact cause of the glaucoma. Doctors think the main cause of the glaucoma is the pressure in the eye. Some people with the normal eye pressure also suffer with glaucoma. There are different kinds of glaucoma such as open angle glaucoma, Angle closure glaucoma, Normal tension glaucoma, Congenital and infantile glaucoma, and secondary glaucoma’s. Beta–adrenergic blockers and prostaglandins are the most frequently used topical medications at present.
Glaucoma is an eye disease which causes damage to the optic nerve damage. Consequently this damage can lead to progressive vision loss or blindness if left untreated. The human eye is constantly making aqueous humor which provides sustenance to surrounding tissues. Maintaining a fluid balance requires the fluid leaving the eye through the drainage system which is a meshwork along the outside edge of the iris. However, if too much fluid is being produced or if the drainage system is not working properly, intraocular pressure builds and in turn causes the optic nerve damage and the deterioration of vision. Most people do not realize they have glaucoma until they are diagnosed and already have peripheral field of vision loss. The main treatment for glaucoma is topical eye drops but when a patient is on maximum eye drops and intraocular pressure is not controlled or if they have many
Glaucoma is not a specific disease but rather a group of diseases characterised by a large variety of clinical and histopathologic signs (Allingham et al., 2012). If left untreated, there is a high chance of becoming blind and loss of vision. The two main types of glaucoma include open angle and angle closure glaucoma. Most of the research done is on primary open angle glaucoma as it is an age-related and can remain undetected until it becomes serious (Weinreb & Khaw, 2004). Primary open angle glaucoma is the most common form of glaucoma in the United States (Scheetz et al., 2013).
Eyesight is the most important of the five senses. The world today revolves around being able to see and understand things. As the average age of the world continues to increase, glaucoma has become increasingly prevalent in the population. Glaucoma currently affects around sixty million people worldwide and is expected to affect eleven million people in two thousand twenty(Mohammadi et al. 3). Losing the gift of sight is unbearable to most people, but glaucoma can be treated if it is caught early enough.
Patients were evaluated 1 day, 5 days, 1 month, 3 months and 6 months after surgery. At each follow-up, the following data were recorded: best-corrected visual acuity, IOP and findings of slit-lamp biomicroscopy of the anterior and posterior segments. Anatomical status and visual outcome were recorded in order to compare the results. The criteria for control of infection were improvement of vision and pain, no recurrence of hypopyon and decrease or absence of cells and flare in the anterior chamber and vitreous. Cases which develop retinal detachment after the first vitrectomy or after silicon oil removal were
Surgical intervention involves Posterior sclerostomy and injection of balanced salt solution or viscoelastic into the anterior chamber. Sclerostomies are usually made inferiorly 4 mm behind the limbus and over the pars plana. Alternatively, 1-mm trephination through the sclera, anterior to the inferior rectus muscle may be done. It remains open for several days and allows suprachoroidal fluid to drain subconjunctivally.17
Intraocular pressure (IOP) is the result of a dynamic balance between aqueous humor formation and outflow. As a main parameter in the evaluation of patients at risk from glaucoma, it also provides the baseline pressure in ocular disease studies. While glaucoma is often associated with elevated IOP, glaucomatous changes in the retina and optic nerve sometimes occur at normal IOP; this is termed
Peter Stalmans and associates143 conducted a randomized control trial. Its data support the finding that intravitreal injection of ocriplasmin leads to resolution of vitreomacular traction, induction of posterior vitreous detachment, and closure of a macular hole in some cases. The incidence of vitrectomy was lower among the patients who received ocriplasmin than among those who received placebo. A sham injection would have provided a better comparison with the natural history of the disease process than that provided by the group of patients who received a placebo, which was chosen to control for the effect of an intravitreal injection. The main visual symptom of vitreomacular traction and macular holes is decreased visual acuity. Although more
Elimination of the possibility of pupillary block glaucoma by verifying or creating a patent iridectomy is essential. Miotic medications should be avoided, and vigorous cycloplegia as well as the use of topical steroids should be started. Aqueous suppressants and hyperosmotics can be used to reduce the pressure. The effect of medical therapy is often not immediate, but approximately 50% of cases will be relieved within 5 days.
The main treatment for glaucoma is topical eye drops, but in cases where a patient is on maximum eye drops and intraocular pressure is not controlled, or the side effects are too extensive or the age and ability of