Transfusion Related Acute Lung Injury

899 Words Nov 23rd, 2015 4 Pages
Transfusion related acute lung injury (TRALI) has been an upcoming cause of transfusion related mortality. It is characterized by the sudden development of non cardiac related pulmonary edema after transfusion of blood products. According to the Food and Drug Administration (FDA), in the past two reporting years, it has been the leading cause of transfusion related deaths. It is of severe importance for physicians, nurses and also laboratory scientists to become familiar with the presentations of TRALI since many cases will remain unnoticed or will be misdiagnosed as fluid overload, or acute lung injury of other etiology. In order to properly diagnose a patient with TRALI, there are several criteria that needs to be followed. There needs to be an acute onset of pulmonary edema within six hours of transfusion, even though most patients will demonstrate lung edema within one to two hours of transfusion. Clinical evidence of hypoxemia and bilateral infiltrates on frontal chest radiograph also needs to be present. Lastly, no evidence of left atrial hypertension (i.e. circulatory overload) is a main criteria to keep in mind. The physician must also rule out any other attributable causes that could possibly lead to lung edema, such as congestive heart failure. In general any blood product could trigger TRALI, but plasma containing blood products are most known to cause TRALI. More specifically plasma containing blood components are most commonly implicated with whole…
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