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Treatment Of Recurrent Erythema Multiforme

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Apremilast for Treatment of Recurrent Erythema Multiforme

Introduction

Recurrent erythema multiforme (EM) is an uncommon skin condition with unclear etiology considered to be a hypersensitivity reaction presenting commonly in young adults with distinctive targetoid skin lesions with or without mucosal lesions. These cases are typically treated with antiviral therapies or immunosuppressive agents in more extreme cases. We present a case of recurrent EM in a young adult that resolved completely after treatment with Otezla (apremilast), an oral medication originally developed for the treatment of psoriasis and psoriatic arthritis.

Case report
A 21-year-old African American female with a history of recurrent skin lesions on lips, tongue and soft palate for over ten years. She was initially diagnosed at age 6 with Behcet’s syndrome due to presence of recurrent oral and genital ulcers as well as joint pain and swelling. She stated that she has about six episodes per year with recurrence after treatment. For acute episodes, she was given treatment with prednisone for management of oral and genital lesions, which has been used intermittently. She was additionally treated with colchicine, dapsone and hydroxychloroquine with no response. It is unclear when these treatments were administered or for what duration the patient adhered to these regimens. Lesions resolved completely with no new lesions after one month of therapy on Otezla. There has not been a recurrence for 4 months.

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