Tuberculosis and its Role in Research
Erica Lin July 7th, 2015
I. Background
Abstract
Tuberculosis, commonly referred to as TB or consumption, is a dangerous pathogen caused by mycobacterium tuberculosis (M. tuberculosis). It is the second-highest cause of death, killing off 1.5 million each year. TB victims are normally infected in the lungs by airborne pathogens and fluids, but other organs can be targeted. There are two types of TB: active, in which victims are infectious and show symptoms, and latent, where victims do not show any signs at all, making TB a silent threat that could manifest in the body without warning.
Epidemiology Tuberculosis is the second-highest cause of death worldwide, and over one and a half million people
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tuberculosis complex (MTBC). When these bacteria enter our body, adverse effects could result in potentially lethal consequences. Tuberculosis is normally an airborne infection, although it can also be transmitted through the bloodstream and tissues. Viral TB culminates when mycobacteria enter the airstream and attack the body, particularly the pulmonary alveoli, invading cells and replicating themselves. Although macrophages attempt to engulf the bacteria and destroy them through phagocytosis in a process called autophagy, the bacteria’s lipid outer coating allow them to survive and eventually utilize the nutrients originally intended for the cell to sustain replication within the host macrophage. If the mycobacteria find their way in through damaged tissue, they can move throughout the body and infect different areas. Inside of the body, phagocytes and T cells in the body will clump together to surround and attack infected macrophages, but this supposedly beneficial bodily response is actually exploited by mycobacteria, who use clumping to block all of the macrophages at once and ultimately avoid host immune response.
TB is usually transmitted through exposure to others with active tuberculosis infections. If the infector has active pulmonary TB and performs any action that expels out salivary or mucous material, that material can transmit the bacteria to others. The bacteria then
Tuberculosis is a disease of an infectious nature caused by a bacterium known as mycobacterium tuberculosis. The disease spreads through the air. People with the disease can spread it to susceptible people through coughing, sneezing, talking or spitting. It mainly affects the lungs and other parts such as the lymph nodes and kidneys can also be affected. The symptoms for TB are fatigue, coughing, night sweats, weight loss and fever. One third of the population of the world is affected with mycobacterium tuberculosis. The rate of infection is estimated to be one person per second. About 14 million people in the world are infected with active tuberculosis. Drug resistant TB has been recorded to be a serious public health hazard in many countries. Resistant strains have developed making it difficult to treat the disease. TB has caused millions of death mainly in people living with HIV/AIDS ADDIN EN.CITE Ginsberg19981447(Ginsberg, 1998)1447144717Ginsberg, Ann M.The Tuberculosis Epidemic: Scientific Challenges and OpportunitiesPublic Health Reports (1974-)Public Health Reports (1974-)128-13611321998Association of Schools of Public Health00333549http://www.jstor.org/stable/4598234( HYPERLINK l "_ENREF_3" o "Ginsberg, 1998 #1447" Ginsberg, 1998). The World Health Organization came up with the DOTS (Directly Observed, Therapy, Short course) strategy. The approach involves diagnosing cases and treating patients with drugs for about 6-8
Tuberculosis is caused by the bacteria “Mycobacterium Tuberculosis” and is mainly causes infection of the lungs (WHO, 2016). Its mode of transmission is airborne, so it can be passed on by inhalation of airborne droplets which carrying the bacteria, when an infected patient coughs, sneezes, or spits the TB germs into the air (WHO, 1026). Among the symptoms of active TB are: cough with sputum and blood, chest pains, weakness, fever and night sweats (WHO, 2016). Most at risk to get the TB infection are people with weakened immune system such as people who are suffering from chronic diseases such as diabetes mellitus, severe kidney disease, silicosis and especially HIV infection (CDC, 2016). Children and Tobacco users are also at greater risk to fall ill with TB.
Tuberculosis (TB) is brought on by a bacterium called Mycobacterium tuberculosis. The microorganisms more often than not assault the lungs, however TB microbes can assault any part of the body, for example, the kidney, spine, and mind. Not everybody infected with TB microbes gets to be sick. Therefore, two TB-related conditions exist: latent TB infection (LTBI) and TB infection. If not treated legitimately, TB can be deadly (CDC, 2016). TB microbes are spread through the air starting with one individual then onto the next. The TB microorganisms are put into the air when someone with TB illness of the lungs or throat coughs, talks, or sings. Individuals adjacent may take in these microscopic organisms and also become ill (CDC, 2016). Individuals with TB are well on the way to spreading it to individuals they invest time with consistently. This incorporates relatives, companions, and coworkers or classmates.
Tuberculosis is a bacterial infection that can be spread in the lungs, lymph nodes, and bloodstream and to any part of an organ in the body. They are two types of tuberculosis which, is active and
According to the World Health Organization, tuberculosis (TB) is the number two killer worldwide due to a single infectious agent (WHO, 2017). In 2015, 10.4 million new cases have been identified and 1.8 million people have died from this disease (WHO, 2017). TB is caused by the bacteria Mycobacterium TB, and the majority of TB deaths occur in low and middle-income countries. This disease is curable and preventable, but the lack of access to proper healthcare and medication administration makes it a concern for the most of the world’s population. TB is an airborne disease that can transmit when an infected person coughs, sneezes, spits, laughs, or talks. The majority of TB cases can be cured when the right medications are available and
Tuberculosis (TB) is caused by a bacteria called Mycobacterium Tuberculosis, which normally affects the lungs, but it can also affect any part of the body, including the bones and the nervous system. The disease is spread easily through prolonged exposure to someone who has the illness, from their coughs and sneezes. For a healthy individual the body’s immune system kills the bacteria and prevents it from spreading in the body, which is known as ‘latent TB’. However, if the immune system fails to fight the bacteria, it can easily spread in the body. Symptoms will develop within a few weeks or months depending on the individual. This is known as an ‘active TB’. The symptoms are, constant coughing that brings up phlegm that may also contain blood, which lasts more than three weeks, combined with weight loss, tiredness and fatigue, loss of appetite and also fever. Without treatment, TB can cause major health problems and if its left untreated can even cause death (NHS 2016).
Tuberculosis (Mycobacterium tuberculosis), also known as TB, is a disease spread by respiratory inhalation of droplets that contain the bacteria. Tuberculosis is an ancient disease that has been traced back at least 9000 years. In 1882, Dr. Robert Koch was the first physician to describe Mycobacterium tuberculosis as the germ responsible for tuberculosis. However, treatment that was evidenced based was not put into practice until the 20th century. It is estimated that 2 billion people around the world are infected with the TB bacteria. Approximately 5 to 10 percent of these infected people will actual develop active TB and experience the life-threatening symptoms of the disease. Tuberculosis
Tuberculosis is a disease caused by Mycobacterium tuberculosis that most commonly affects the lungs. The etiologic agent can be expelled from one infected person via a sneeze or a cough, and enter the air and then the body of another person, leading to another infected person (“Tuberculosis, 2012). According to “What is TB?” (n.d.), someone who has diagnosed tuberculosis but is not receiving any form of treatment can pass the disease to up to 15 people in on year. Treatment of TB is necessary, so if symptoms are ignored, an infected person could die. Prevalence of this disease is not as common in the United States as it is in other countries. In 2014, there were approximately 9,421 reported cases; trends show that TB prevalence continues to decreases each year. Of
Tuberculosis, TB (tubercle bacillus) or MTB (mycobacterium tuberculosis) is a widespread, and in numerous cases fatal, communicable disease produced by a variety of forms of mycobacteria. The disease is distributed within the air when individuals who are infected with active TB infection sneeze, cough, or pass on breathing fluids throughout the air. Generally infections are asymptomatic, meaning they feel or show no symptoms, and dormant, but then again approximately one in ten dormant infections in the long run move on to the active disease. If left untouched, active TB is fatal to more than half of those infected.
Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis, which most commonly attacks the lungs (2). Moreover, it makes the lungs unhealthy and infected. It is transmitted from one person to another via droplets. For example, from the throats and lungs of people infected with this active respiratory disease (2). In 2012, nearly nine million people around the
Mycobacterium tuberculosis is one of the most overwhelming pathogens that to the day is known for produce annually around 2-3 million casualties worldwide.
Tuberculosis (TB) is the disease of the lung caused by a slow-growing intracellular pathogen called Mycobacterium tuberculosis (M.tb) (1). In 2014, there were 9.6 million cases of active TB disease worldwide, and 1.2 million TB-related deaths according to World Health Organization (WHO) (2). The burden of the disease can be appreciated with the knowledge that one third of the world population is latently infected with M.tb, and 5-10% of exposed individuals develop active disease and are able to spread the infection to more people every year (3,1). To reduce this burden, effective strategies are required in both preventative and therapeutic areas of research.
Tuberculosis (TB) is a chronic bacterial infection that affects millions of people globally. It is a contagious disease that is spread through the air, and it usually affects the lungs. It is transmitted from person to person through droplets from the respiratory tract of those who are already infected with the disease. Some who are infected with the bacteria that causes TB often exhibit no symptoms, because their immune systems stop the bacteria from growing and multiplying. Those with compromised immune systems are more susceptible to developing the full blown disease which can cause symptoms that include coughing, spitting blood, chest pains, weakness, weight loss, and fever. Tuberculosis can be treated with a six to nine month course of a combination of antibiotics. If left untreated, TB will spread and can be fatal.
Tuberculosis (TB) is a chronic infectious multi systemic disease caused by mycobacterium tuberculosis and is one of the leading causes of
Tuberculosis is among the fatal diseases that are spread through the air. It’s contagious, meaning that it spreads from one infected individual to another, and at times it spreads very fast. In addition to being contagious, the disease is an opportunist infection as it takes advantage of those with weak defense mechanism, and especially the ones with terminal diseases like HIV and AIDS. Tuberculosis is therefore among the major concerns for the World Health Organization due to its contagious nature (World Health Organization 1).