Types Of Collagen Type I Collagen

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Since the beginning of 20th century, collagen has been reviewed extensively in studies and researches. Collagen is the most abundant protein in vertebras and signifies 30% of the proteins in the body. The composition of collagen is manifested in various parts of the body like bone, skin, cartilage and blood vessel. Collagen fibre is the main structure in extracellular matrix contributing great assistance in maintaining the integrity of cells and tissues structures. The major functions of collagen include the provision of strength and elasticity, along with maintaining rigidity. Till date, 28 types of collagen have been identified and they are classified into few sub-group. A number of factors distinguish a collagen from another such as morphological characteristics, molecular compositions, distributions, and functions. Of all types of collagen, type I collagen is the most abundant form and is responsible for substituting 90% of the body’s collagen. In view of the important of collagen type I collagen in human body structures and functions, the aim of this paper is to provide in-depth information about type I collagen post-translational modification process, and diseases that are governed by it.

Collagen has few subgroups and fibril forming collagen is the largest group in the human body. Type I collagen is found in most of the connective tissues, especially bone, tendon, ligament, cornea and skin. It provides tensile strength to these structures. The interaction of fibrils
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