Types Of Collagen Type I Collagen

Most types of connective tissue contain fibrous strands of the protein collagen that add strength to connective tissue. Some examples of connective tissue include the inner layers of skin, tendons, ligaments, cartilage, areolar, adipose bone and fat tissue. In addition to these more recognizable forms of connective tissue, blood is also considered a form of connective tissue.

58) Connective tissues that possess a large quantity of collagen fibers often provide the framework for organs such

3-6: This slide shows a section of a tendon with regularly arranged closely packed collagen fibers running in the same direction. This results in a flexible tissue with great resistance to pulling forces. With its enormous tensile strength, this tissue forms cord like tendons, which join muscles to bones, sheet-like aponeuroses, which attach muscles to muscles or muscles to bones, and ligaments, which bind bones together at joints.

Connective tissue - Connective tissues holds and binds everything together which are found all around the body. This type of tissue is also called fibrous connective tissues as they are consisting of a lot of fibres eg. Collagen and Elastin.

They are very strong, yet lightweight. Dense connective tissue, are cells crowded between collagen fibers. Loose connective tissue is the most common type of tissue in vertebrates. It holds the organs in place, and attaches to epithelial tissue. Reticular connective tissue is found around the liver, the kidney, the spleen, the lymph nodes, and in bone marrow. It forms a soft skeleton that supports. Blood is used to transport oxygen and nutrients to the cells.

The second type of tissue found in the body is connective tissue. They lie beneath the epithelial tissue helping to connect different part of the internal structure, the cells are more widely separated from each other then in epithelial tissue. The intercellular substance known as the matrix is found in considerably large amounts. Within the matrix there are usually fibres which may be a jelly like consistency or dense and rigid depending on the type, function and positioning of the tissue. Theses fibres form a supporting system for cells to attach to. The major functions of connective tissue are to transport materials, give structural support and protection. The types of connective tissue that will be explained are blood, bone, cartilage, bone, areolar tissue and adipose tissue.

The nuclei of the cells that secrete the collagen fibers are indicated by the number 1. What type cells are these?

The three primary muscle fiber types are Type I, Type IIA, and Type IIB. Type I or slow-twitch muscle fibers are predominantly used for aerobic activities, such as running and walking, and the main fiber type found in the body types of endurance athletes like marathon runners. These body types are characterized as ectomorphic or slim, linear body type. I would train an individual with a body type primarily of Type I muscle fibers, by encouraging exercises with higher repetitions (e.g., 12 repetitions or more, with 2 to 3 working sets), higher volume and shorter rest periods, in order to engage the greatest number of those muscle fibers. This is because Type I muscle fibers require more work to maximize growth or hypertrophy, take longer to fatigue and recover quickly.

The COL1A1 gene provides instruction for making part of a large molecule called type 1 collagen. Collagens are used to strengthen and support many tissues in the body such as cartilage, bone, tendon, skin, and the white part of the eye. Type 1 collagen is the most abundant form of collagen in the human body. The defect in the structure of type 1 collagen weakens connective tissues, particularly bone. This results in the characteristic features of OI. The genes CRTAP and P3H1 are genes that

Its capability to generate its own gene response brings about persistant activation of collagen gene expression. TGFβ are present in the autocrine signaling system of fibroblasts, a type of cell which systhesizes collagen in order to build the frame work unit of tissues. The autocrine signaling system is the process in which the cell binds its own produced hormones and chemicals to activate a response or change within the cell. It is believed that if TGFβ in fibroblasts the increased collagen gene experession may drive the over production of collagen giving rise to

Simple squamous epithelial cells are flattened horizontally and their cytoplasm is thin. The simple squamous cells allow passage of materials by diffusion and filtration in places where protection is not important. Because the cells are flat and have thin cytoplasm, it allows for easy passage of materials.

Type I collagen clearly contributes to the integrity and strength of bone matrix, and defects in its production leads to bone of poor quality, susceptible to fracture( Kini and Nandeesh 2012). Type I collagen is a triple helical structure consisting of two identical a1 chains and one a2 chain with a non-helical region where the N-telopeptide and C-telopeptide join to the crosslinks (Brown et al.,2009; Bergmann et al., 2009 ; Seibel 2005). During type I collagen synthesis, pro-peptides are released both from the N-terminal and C-terminal ends of the procollagen molecule, after the three individual alpha chains have created the triple helix, which will become part of the collagen fibril( Kini and Nandeesh

Fibrous joints are classified as having articulating bones joined by dense regular connective tissue (mainly consisting of collagen) and no joint cavity(3). Majority of fibrous joints are synarthroses or amphiarthroses. The three types of fibrous joints are sutures, gomphoses, and syndesmoses. Sutures are synarthroses joints present on the skull(2). The sutural ligament which is composed of connective tissue fibers and is continuous with the periosteum joins the two skull bones(1,2). Sutures give strength and allow growth of the skull during childhood(3). Once growth has occurred the dense regular connective tissue becomes ossified and the bones fuse together(3). Gomphoses are synarthrosis joints that only occur between teeth and sockets of the mandible and maxillae(3). Collagen fibers in the periodontal ligament link the root of the tooth and the bony socket(1).

Connective Tissue Label the parts of the organ or structure, and describe the structure and its function. NumberStructureCharacteristics Function 1Areolar connective tissueWidely distributed found under skin, around organs, between muscles.Wraps and cushions organs.2Adipose (fat) tissueFound under skin, around kidneys and heart.Functions in energy storage and insulation cushioning for organs.3Dense connective tissueFound in tendons and ligaments.Forms strong bands that attach bone to muscle or bone to bone. Identify the location of each type of connective tissue in a specific organ of the human body and describe the structure of each type of tissue as it is related to its function. Connective Tissue TypeLocationStructure Adipose tissueFound under skin, around kidneys and heart. LooseBlood Within blood vessels.FluidBone Skeleton.SolidHyaline cartilage found at the ends of long bonesFlexibleElastic cartilageIs found in the external ear, where it provides strength and elasticity.FlexibleFibrocartilage cushioning layer in the knee joint as well as the outer part of the shock absorbing disks between the vertebrae of the spine.FlexibleDense connective tissueTendons, ligaments.Dense What is the difference between a ligament and a tendon A tendon is a fibrous connective tissue which attaches muscle to bone. A ligament is a fibrous connective tissue which attaches bone to bone, and usually serves to hold structures together and keep them stable. What is the difference

About one quarter of all the protein in your body is collagen. It is a major structural material that forms molecular cables to strengthen the tendons and resilient sheets that support the skin and internal organs. Bones and teeth are made by adding mineral crystals to collagen. Collagen provides structure to our bodies, protecting and supporting the softer tissues and connecting them with the skeleton. But, in spite of its critical function in the body, collagen is a relatively simple protein.