Types Of Multiple Organ Dysfunction Syndrome

1759 Words Mar 13th, 2016 8 Pages
Multiple Organ Dysfunction Syndrome, also known as MODS, can occur after any severe injury or disease process that activates a large systemic inflammatory response which includes any kind of shock (Sole, 2013, 283). Like with any kind of dysfunction, organ dysfunction can lead to further organ failure and ultimately death (Sole, 2013, 283). The most common causes of MODS includes severe sepsis and septic shock, which represents the highest cause of mortality in these conditions (Semeraro, 2011, 293). The body’s immune system along with the body’s response to stress can be a precipitating factor to maldistribution of circulating volume, global tissue hypoxia, and metabolic alterations which results in damage to the organs
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When the injured organs attempt to continue interaction, ceaseless inflammation with maldistribution of the flow of blood and increased metabolism ensue (Sole, 2013, 283)
According to Sole (2013), the maldistribution of blood flow occurs when there is an uneven volume of blood circulating between the organs, vessels, tissues, and cells. When the blood flow through the body is disturbed, it leads to impaired perfusion of the tissues, therefore resulting in decreased oxygen being transported to the cells (Sole, 2013, 283). According to Sole (2013), the liver, splanchnic bed, kidneys, and lungs are the most affected when maldistribution of blood flow occurs.
Hypermetabolism including altered carbohydrate, lipid, and fat metabolism is a compensatory mechanism in the initial stages of organ dysfunction to meet the body’s higher requirements for energy (Sole, 2013, 283). Hypermetabolism becomes harmful to the body after time because of the increased demands on the heart (Sole, 2013, 283). Hyperglycemia is also a factor because of the increased rate of glucose production by the liver and decreased glucose use by the cells (Sole, 2013, 283).
During MODS, an imbalance of oxygen supply and demand occurs, which is a direct result of maldistribution of the blood flow, where the cells are not getting enough oxygen, and
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