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Unique Amino Acid Requirements in Endurance Athletes

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Knowledge gap
There is ongoing research in the field of sports nutrition that focus on proteins and specific amino acid pathways and how they relate to muscle synthesis and degradation. Research on resistance training and amino acids is quite thorough but is lacking in regards to endurance exercise and amino acids. High-intensity endurance training is important to improve the physical performance of athletes and requires amino acids as an energy substrate. Because high amounts of energy are required during training, amino acid supplementation has been used to increase the availability of amino acids to decrease the degradation of muscle protein and the effect of overtraining. Two of the main components of supplements that are popular with endurance athletes are BCAA and glutamine. There are divergent results on the impact of BCAA and glutamine supplementation on improving athletic performance and preventing muscle break down. As a health professional, another important component to look at would be the amount of these amino acids that are in popular supplements and if there is any potential negative side effects that could occur. Clinical studies on gene defects in the catabolic pathways for BCAAs demonstration their toxicity. The most known inherited disorder is Maple syrup urine disease (MSUD) which is caused by defects in the genes encoding the subunits of branched-chain α-ketoacid dehydrogenase complex (BCKDC). The neurological damage that occurs in MSUD

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