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What Are The Importance Of Natural Products

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In spite of impressive recent advances of synthetic drugs, the approach to develop newer drugs from chemical libraries, however, was proven to be less useful in terms of overall success rate. In recent years, there is a renewed interest on natural product research due to the failure of alternative drug discovery methods to convey many lead compounds in the major therapeutic areas such as immunosuppression, metabolic diseases and anti-infectives. Natural products acquire massive structural and chemical diversity which is incomparable by any synthetic libraries. About 40% of the chemical scaffolds observed in natural products are deficient in today’s medicinal chemistry and thus become complementary to synthetically developed molecules. …show more content…

Existing data on A. paniculata also clearly conveys a wide spectrum of pharmacological properties of this plant. Due to its immeasurable pharmacological activities, A. paniculata can be safely considered as one of the modern catholicons. Nevertheless, the reported pharmacological activities of A. paniculata require further validation through the clinical study. Pharmacological activities of A. paniculata were investigated using either crude extracts or isolated bioactive constituents. Although the crude extract manifested significant effects, isolation of the major bioactive constituent, andrographolide and investigation of its pharmacology offer more explicit knowledge particularly about the mechanism of actions. Authentication of the usefulness of other biological activities of andrographolide including anticancer, antidiabetic, anti-inflammatory, and hepatoprotective activities would fetch a lot of benefits for the largest population of the globe. This work majorly focuses on the medicinal properties and the pharmacological effects of andrographolide (a major active constituent of A. paniculata) including anticancer, anti-bacterial and antiparasite activities. During this investigation, andrographolide has been found to possess the following effects:  Anticancer activities This dissertation confirms that apoptosis was induced efficiently by andrographolide in the mutant p53, triple

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