Zno Nps And Silica Based Nannomaterials : The Human Case Study
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Nanomaterials including ZnO NPs and silica based nanomaterials can enter the body through different routes via intraperitonial, intravenous, intradermal, subcutaneous, oral or by inhalation. After entering inside the body, NPs can cause pulmonary toxicity (Kaewamatawong et al., 2006; Jacobsen et al., 2015), hepatotoxicity (Mansouri et al., 2015; Watson et al., 2015), immunotoxicity (Kim et al., 2014), neurotoxicity (Karmakar et al., 2014), renal toxicity (Ben-Slama et al., 2015; Chen et al., 2015) and reprotoxicity (Xu et al., 2014). Due to their nanosize range, nanoparticles can cross the blood-testis and blood-brain barrier, and also have the trans-placental ability (De Jong et al., 2008; Lankveld et al., 2010). After crossing the…show more content…
No deaths occurred in the offsprings exposed in utero with 50 or 100 mg/kg BW of ZnO NPs, 100 mg/kg BW of bulk ZnO or even for a high 250 mg/kg BW of MSN. Developing foetuses are more sensitive to the environmental toxins than the adults and it has been reported that many chemical toxins in the air, water and food can induce pregnancy complications (Korenet al., 1998; Tardiff et al., 2006; Wigle et al., 2008). In the current study and very importantly no change in the number of litters was observed for any of the nanomaterials tested and that too at any concentrations. Therefore we can safely say that ZnO NPs, bulk ZnO or very high MSN exposure did not affect the live birth rate compared with the control. However, miscarriages were observed in the pregnant mice treated with only a single dose of 300 mg/kg BW of ZnO NPs, and we did not get any live offsprings in this group. Dysfunction of the placenta is related with the miscarriage and fetal growth restriction (Gasperowicz and Otto, 2008). Our results are indicating that ZnO NPs at higher dose (300 mg/kg BW) can cause adverse effects on the developing fetus, and may cause placental dysfunction (Table 1). In the present study, gross macroscopic changes were observed in the ZnO NPs exposed offsprings when compared with the control. No change in the body weights was observed in both treated and non-treated mother mice. Increased testicular weight in the 100 mg/kg BW of ZnO NPs
No deaths occurred in the offsprings exposed in utero with 50 or 100 mg/kg BW of ZnO NPs, 100 mg/kg BW of bulk ZnO or even for a high 250 mg/kg BW of MSN. Developing foetuses are more sensitive to the environmental toxins than the adults and it has been reported that many chemical toxins in the air, water and food can induce pregnancy complications (Korenet al., 1998; Tardiff et al., 2006; Wigle et al., 2008). In the current study and very importantly no change in the number of litters was observed for any of the nanomaterials tested and that too at any concentrations. Therefore we can safely say that ZnO NPs, bulk ZnO or very high MSN exposure did not affect the live birth rate compared with the control. However, miscarriages were observed in the pregnant mice treated with only a single dose of 300 mg/kg BW of ZnO NPs, and we did not get any live offsprings in this group. Dysfunction of the placenta is related with the miscarriage and fetal growth restriction (Gasperowicz and Otto, 2008). Our results are indicating that ZnO NPs at higher dose (300 mg/kg BW) can cause adverse effects on the developing fetus, and may cause placental dysfunction (Table 1). In the present study, gross macroscopic changes were observed in the ZnO NPs exposed offsprings when compared with the control. No change in the body weights was observed in both treated and non-treated mother mice. Increased testicular weight in the 100 mg/kg BW of ZnO NPs
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